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All Journal Best Journal (Biology Education, Sains and Technology) Jurnal Penelitian Farmasi dan Herbal
masria phetheresia sianipar
Institut Kesehatan Deli Husada Deli Tua
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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FORMULASI SEDIAAN SALEP KOMBINASI EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) DAN DAUN KERSEN (Muntingia calabura L.)TERHADAP PENYEMBUHAN LUKA TERBUKA PADA TIKUS JANTAN PUTIH TAHUN 2022 masria phetheresia sianipar
Jurnal Penelitian Farmasi & Herbal Vol 5 No 2 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i2.1066

Abstract

Background: Wounds are damage to part of body tissue or damage to tissue components, where there are damaged or missing tissue substances. Jackfruit leaves (Artocarpus heterophyllus Lam.) contain secondary metabolites, namely, flavonoids, saponins and tannins. Flavonoids function as antibacterial and reduce inflammation in wounds. Saponins to trigger the formation of collagen. While the tannins function as an antibacterial. Cherry leaves (Muntingia calabura L.) contain several active compounds such as flavonoids, saponins, and tannins. Compounds that function as anti-inflammatory are flavonoids. These compounds can accelerate wound healing because it has anti-inflammatory activity. Objective: to determine the concentration of the combination ointment of jackfruit leaf and cherry leaf ethanol extract in the form of an ointment that is most effective in healing open wounds. Method : Experimentally. Samples using jackfruit and cherry leaves were taken purposively, extracted by maceration using 96% ethanol as a solvent made in the form of a thick extract. Then the thick extract was made into an ointment with a ratio of 1:2, 2:1 and 2:2 as well as positive control (bacitracin ointment), negative control (ointment base). open wound for 14 days. Results: The results of the open wound healing study had the best effectiveness, namely bacitracin ointment (0 cm), a combination ointment of jackfruit leaf and cherry ethanol extract 2:2 (0.10 cm), 1:2 (0.25 cm) and 2 :1 (0.28 cm) then ointment base (0.55 cm). Conclusion : The preparation of ointment combination of jackfruit leaf ethanol extract and 2:2 cherry is more effective in the treatment of open wounds.
Uji Aktivitas Anti Oksidan Fraksi Etil Asetat Bunga Kecombrang (Etlingera elatior) Dengan Metode DPPH Lidia Klorida Barus; Sofia Eliasari Bangun; Masria Phetheresia Sianipar
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 2 (2025): September 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i2.12798

Abstract

Abstrak Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan fraksi etil asetat bunga jahe obor (Etlingera elatior) menggunakan metode DPPH. Penelitian ini dilakukan secara eksperimental melalui ekstraksi dan fraksinasi sampel, kemudian dilakukan pengujian menggunakan spektrofotometri UV-Vis untuk menentukan nilai IC50. Hasil penelitian menunjukkan potensi antioksidan yang kuat dari fraksi tersebut. Penelitian ini menggunakan metode eksperimental yang dilakukan di laboratorium. Sampel bunga jahe obor diekstraksi menggunakan etanol 96%, kemudian difraksinasi dengan pelarut n-heksana, etil asetat, dan etanol. Pengujian aktivitas antioksidan dilakukan menggunakan metode DPPH dan dianalisis menggunakan spektrofotometri UV-Vis untuk menentukan nilai IC50 fraksi etil asetat. Hasil penelitian menunjukkan bahwa fraksi etil asetat bunga jahe obor memiliki aktivitas antioksidan yang sangat kuat. Nilai IC50 yang diperoleh berada di bawah 50 µg/mL, menunjukkan kemampuan yang tinggi dalam menangkal radikal bebas. Aktivitas ini dikonfirmasi melalui pengujian DPPH dan analisis menggunakan spektrofotometri UV-Vis. Kesimpulan dari penelitian ini adalah fraksi etil asetat dari bunga jahe obor memiliki aktivitas antioksidan yang sangat kuat dengan nilai IC50 kurang dari 50 µg/mL. Rekomendasi untuk penelitian lebih lanjut meliputi isolasi senyawa aktif spesifik dan pengembangan potensi bunga jahe obor sebagai bahan dasar untuk produk herbal atau suplemen kesehatan alami dan aman
PENETAPAN KADAR AKRILAMIDA PADA MAKANAN HEWANI DAN NABATI PANGGANG DENGAN METODE SPEKTROFOTOMETRI UV-VIS Sofia Eliasari Br Bangun; Sulasmi Sulasmi; Masria Phetheresia Sianipar
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2943

Abstract

This study aimed to determine the acrylamide levels in animal-based (grilled chicken and grilled fish) and plant-based (grilled Cilembu sweet potato) foods using the UV-Vis spectrophotometry method. Acrylamide is a carcinogenic compound formed in foods heated to high temperatures. The samples were tested qualitatively and quantitatively. Qualitative tests confirmed the presence of acrylamide in all three samples. Quantitative measurement was performed at a maximum wavelength of 267 nm and showed the average acrylamide levels in grilled Cilembu sweet potato, grilled chicken, and grilled fish were 51.3964 mcg/g, 38.1875 mcg/g, and 32.1383 mcg/g, respectively. The highest level was found in the grilled Cilembu sweet potato due to its higher carbohydrate content. Although the detected levels are below the daily toxic limit set by BPOM, excessive long-term consumption is not recommended. The method validation test showed results that met the requirements for linearity (r = 0.995) , accuracy (recovery range 101.58% - 106.33%) , and precision (RSD < 2%) , with LOD and LOQ values of 0.4111 and 1.3703, respectively. It was concluded that the UV-Vis spectrophotometry method is effective for the analysis of acrylamide in grilled food samples.
Co-Authors Lidia Klorida Barus Sofia Eliasari Bangun Sofia Eliasari Br Bangun Sulasmi Sulasmi