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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences ASIAN JOURNAL FOR POVERTY STUDIES (AJPS)
Murni Nur Islamiah Kassim, Murni Nur Islamiah
Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu, Terengganu, Malaysia
Earth & Planetary Sciences Social Sciences

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THE POTENTIAL USE OF Phaleria macrocarpa LEAVES EXTRACT AS AN ALTERNATIVE DRUG FOR BREAST CANCER AMONG WOMEN LIVING IN POVERTY Amir, Hermansyah; Murcitro, Bambang Gonggo; Ahmad, Ahmad Shamsudin; Kassim, Murni Nur Islamiah
ASIAN JOURNAL FOR POVERTY STUDIES (AJPS) Vol 3, No 2 (2017)
Publisher : Regional Network on Poverty Eradication

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Abstract

Cancer is recognized as global threat to human development and it was estimated that in 2030 there will be 22.2 million new cases of cancer and 12.7 million cancer-related deaths worldwide. Herbal medicine plant till this day all over in the word is still the main source and one of the most important fields of traditional medicine agents to fight breast cancer. The usage of plants is still important because has its own beaviour advantages such as low toxicity, easy to get, cheap and has less side effect if it is used in a right. One of this plant it has been used as a traditional medicine is a Phaleria macrocarpa (Scheff) Boerl) also known as Mahkota Dewa from Papua island. It has been used traditionally for treatment of cancers in Indonesia and also to cure many diseases. The therapeutic effect of Phaleria macrocarpa (Scheff) Boerl, is related to the its bioactive compounds contents. There are many reported compounds from Phaleria macrocarpa (Scheff) Boerl, which are found, reported and published such as Icariside, phalerin, mangiferin, gallic acid, 29-Norcucurbitacin, gentiobioside and glucoside. All compounds reported above have already published as anticancer agents,where anticancer activity were detected and showed against Hela cells, leukemia cells, cervical cancer, breast cancer, and L1210 cells. Research on Phaleria macrocarpa (Scheff.) Boerl fruit and leaves merit have been done and published, however, there are very limited research on linked correlation between the concentration of compounds and its the cytotoxicity  level. Because of that, research about correlation level of Phaleria macrocarpa (Scheff) Boerl leaves extract still need to investigate to find the relationship between them in the goal to investigate alternative low cost herbal medicine agents to fight breast cancer especially useful for low income people, thus, information about Phaleria macrocarpa (Scheff.) Boerl.Leaves became more complete. Cytotoxicity properties of samples against breast cancer cell lines was performed by using the MTT assay against MCF-7 cell line. The correlation between concentration of crude and cytotoxic activity was interpreted by statistical analyses. The study showed that Phaleria macrocarpa (Scheff) Boerl.) leaves extracts showed cytoxicity activity against breast cancer MCF7 cell lines. Correlation between concentration of extract and cytotoxicity property (absorbance value) were founded in weak relationship (R = -0.37181). It could be effect of many different compounds in the Phaleria macrocarpa (Scheff) Boerl.) leaves methanol extracts may cause the pharmacological interactions, so lower or higher concentration will be antagonistic effect on absorbance or cell viability.Further study on its mechanism pathway on revealing against breast cancer could be explored. Furthermore, the natural product derived from Phaleria macrocarpa (Scheff) Boerl.) leaves extracts have potential use in cheap alternative agents against breast cancer
Teripang, Sea Cucumber (Stichopus sp.) Fractions Induce Apoptosis in Liver Cancer Cell Line (HepG2) Andriani, Yosie; Kassim, Murni Nur Islamiah; Oksal, Efriyana; Rosmiati, Rosmiati; Bakar, Kamariah; Aziz, Nur Asniza; Syamsumir, Desy Fitrya; Kholieqoh, Alifah Husnun; Sung, Yeong Yik; Sarjono, Purbowatiningrum Ria; Hudiyanti, Dwi; Tengku Muhammad, Tengku Sifzizul
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 31, No 1 (2026): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.31.1.71-78

Abstract

Cancer remains a major global health problem, prompting continuous exploration of marine organisms as sources of novel bioactive compounds. This study evaluated the cytotoxic and apoptosis-inducing activities of F9 and F10 fractions obtained from methanolic extracts of sea cucumber (Stichopus sp.) against the human hepatocellular carcinoma cell line HepG2 as an in vitro cancer model. Sea cucumber samples were extracted using methanol maceration and subsequently fractionated through Medium Pressure Liquid Chromatography (MPLC) to obtain bioactive fractions. Cytotoxic activity was assessed using the MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay after 24, 48, and 72 h of incubation to determine cell viability. Apoptotic effects were examined using Annexin V and propidium iodide (PI) staining, followed by fluorescence microscopy to evaluate morphological changes associated with apoptosis. The results demonstrated that both fractions exhibited significant cytotoxic effects on HepG2 cells in a time-dependent manner, with IC50 values of 14 µg.ml-1 for the F9 fraction and 23 µg.ml-1 for the F10 fraction after 72 h of treatment. Among the tested fractions, F9 showed stronger cytotoxic activity at lower concentrations. Morphological observations revealed typical apoptotic characteristics such as cell shrinkage, membrane blebbing, nuclear condensation, and phosphatidylserine externalization, indicating apoptosis as the predominant mechanism of cell death. These findings demonstrate that Stichopus sp. contains bioactive compounds with anticancer potential. This study highlights the importance of marine invertebrates as natural resources for biomedical applications and supports the development of marine biotechnology strategies for cancer therapy. Further investigations are needed to identify the active compounds responsible and clarify their molecular mechanisms of action.
Co-Authors Ahmad Shamsudin Ahmad, Ahmad Shamsudin Aziz, Nur Asniza Bakar, Kamariah Bambang Gonggo Murcitro Dwi Hudiyanti Hermansyah Amir, Hermansyah Kholieqoh, Alifah Husnun Oksal, Efriyana Purbowatiningrum Ria Sarjono Rosmiati Rosmiati Sung, Yeong Yik Syamsumir, Desy Fitrya Tengku Muhammad, Tengku Sifzizul Yosie Andriani