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A Desaign of Caffeate Acid Derivatives for Anticancer based on DFT Molecular Docking: Studi Senyawa Turunan Asam Kafeat sebagai Antikanker: Pendekatan DFT dan Molecular Docking Oksal, Efriyana; Ariefin, Mokhamat; Pasaribu, Marvin Horale
Jurnal Jejaring Matematika dan Sains Vol. 5 No. 1 (2023): Jurnal Jejaring Matematika dan Sains
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.2023.v5.i1.804

Abstract

This research informs a descriptive study of caffeic acid derivatives such as ethyl caffeate, fluoro methyl caffeate, chloro methyl caffeate, bromo methyl caffeate, iodo methyl caffeate compounds, using density functional theory in B3LYP method with def2-TZVP basis set. The substitution of various halide atoms in the derivative compounds showed a high increase in chemical reactivity than the methyl group for the main compound by increasing the electron donor ability of the compound in chemical reactions. The molecular structures of some derivative compounds were optimized with geometrical analysis values depicting stable molecular structures with lower HOMO-LUMO energy difference. Quantum chemical parameters such as hardness (η), softness (σ), electronegativity (χ), and electrophilicity (ω) were generated as descriptors for the chemical behavior of the molecules. The FT-IR vibrational frequencies that have been calculated and characterized are in good agreement with the molecular structure. The molecular docking results show that the five ligands are able to interact with amino acid residues similar to the amino acids of the native ligand. The binding energy values for the five native ligands are -6.5, -6.8, -6.6, -6.5, and -6.4 kcal mol-1. Furthermore, binding and interaction values similar to the native ligand, it is expected that the five ligands have potential as anticancer.
A REVIEW ARTICLE: ANTIOXIDANT ACTIVITY IN KALAKAI (Stenochlaena palustris): ARTIKEL REVIEW: AKTIVITAS ANTIOKSIDAN PADA KALAKAI (Stenochlaena palustris) Oksal, Efriyana; Ayuchecaria, Noverda; Agnestisia, Retno; Ariska, Risya; Tampubolon, Mulani Jeni Lestari; Dewi, Sintia Ayu; Maulana, Ilham; Rizkita, Aden Dhana
ALOTROP Vol. 7 No. 2 (2023): Alotrop 2023
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/alo.v7i2.29209

Abstract

Kalakai (scientific name Stenochlaena palustris) is a type of fern that is often used by the people of Kalimantan as a vegetable. The Kalakai plant which grows a lot in the lowland swamp areas of Central Kalimantan is a type of fern plant. Kalakai contains high levels of minerals, vitamin C, folic acid, and protein when compared to other local vegetables in Palangka Raya, Central Kalimantan. The active compounds that act as antioxidants in kalakai are flavonoids and phenols. Flavonoids and phenols act as free radical scavengers to prevent diseases that attack the body thereby strengthening the body's immunity. Traditionally, kalakai is consumed by the Dayak people. This article is a review article that uses the descriptive literature study method to find scientific information or research that proves coherently the benefits or applications of the kalakai. Kalakai which activity as an antioxidant has health benefits such as being able to increase hemoglobin levels so that it can prevent anemia has cytotoxicity in MCF-7 breast cancer cells and prevents antihyperlipidemic by reducing Low-density lipoprotein (LDL).
SKRINING FITOKIMIA DAN UJI ANTIBAKTERI EKSTRAK ETANOL DAUN HANJUANG MERAH (Cordyline fruticose) TERHADAP BAKTERI Staphylococcus epidermidis Ayuchecaria, Noverda; Sri Martani, Natalia; Kartika Komara, Nisa; Chuchita; Pereiz, Zimon; Oksal, Efriyana
Jurnal Insan Farmasi Indonesia Vol 7 No 1 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i1.1683

Abstract

Hanjuang Merah (Cordyline fruticosa) is one of the plants used by the Dayak people as traditional medicine. Red hanjuang is an ornamental plant that is very abundant in Indonesia, but there is still not much research that proves the efficacy of red hanjuang. The aim of this research was to determine the phytochemical screening and antibacterial activity of leaf extract of hanjuang merah (Cordyline fruticose) against the bacteria Staphylococcus epidermidis. The method used in sample extraction was maceration, while in the antibacterial test used the paper strip diffusion method with concentrations of 25%, 50%, 75% and 100%. The yield of ethanol extract of hanjuang merah leaf was 11.35%. There was an increase in the diameter of the inhibition zone with the addition of the concentration of ethanol extract of hanjuang merah leaf. The addition of ethanol extract of hanjuang merah leaf at a concentration of 75% sensitive inhibited the growth of Staphylococcus epidermidis bacteria. Secondary metabolites such as tannins, alkaloids, saponins, flavonoids and quinones found in ethanol extract of hanjuang merah leaves are considered responsible for inhibiting the growth of Staphylococcus epidermidis bacteria.
Permen Buah Karamunting: Inovasi Pangan Lokal untuk Penanggulangan Stunting pada Anak Pereiz, Zimon; Oksal, Efriyana; Chuchita, Chuchita; Sylvani, Miranti Maya; Komara, Nisa Kartika
Yumary: Jurnal Pengabdian kepada Masyarakat Vol. 4 No. 4 (2024): Juni
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/yumary.v4i4.2515

Abstract

Purpose: Stunting is a condition in which a child's physical growth and development are hampered due to malnutrition during the growth period. This condition occurs in children under 5 years of age. This age period is critical for the formation and development of body organs in children. Therefore, an innovative and holistic approach is needed to prevent stunting. One potential that can be exploited is the fruit of the karamunting plant (Rhodomyrtus tomentosa), which has traditionally been used as an herbal medicine. Candy containing healthy and delicious caramunting fruits can be an interesting way to increase nutritional intake, especially for children who have barriers to consuming nutritious food. Methodology: Implementation of community service through an educational workshop on the importance of knowledge about stunting prevention in children through local food innovation with Karamunting fruit candy (Rhodomyrtus tomentosa) was carried out on Saturday, October 7, 2023, between: 08.00-11.00 WIB, with the activity location at Habaring Hurung Village Hall. The partners for this community service activity are the heads and staff of Habaring Hurung Village, Bukit Batu District, Palangka Raya City, and Central Kalimantan. The targets of this service activity are mothers and children in Posyandu. Service procedures are the coordination, observation, activity implementation, and evaluation stages. Results: The participants understood the dangers and prevention of stunting in their children. The participants understood how to make karamunting fruit candy a local food that can be used and developed. Limitations: Karamunting fruit candy as a food innovation to prevent stunting produced by this community service program has no known expiration date or shelf life and there is no standard composition or dosage for candy to prevent stunting. Contribution: This community service activity can have a positive impact on the people of Hurung Village. This activity is able to increase insight and the ability to prevent the spread of stunting through innovation in making candy from karamunting fruit, even if residents can implement it independently.
ISOLASI BAKTERI ENDOFIT DARI TUMBUHAN KELAKAI (Stenochlaena palustris (Burm) Bedd). Oksal, Efriyana; Ngazizah, Febri Nur; chuchita; Irawan, Ahmad; Pereiz, Zimon
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/8x82wj94

Abstract

Kelakai (Stenochlaena palustris) is a type of medicinal fern used by the Dayak ethnic community in traditional medicine. The diverse bioactivity of kelakai is closely related to its high antioxidant content. The phytochemical compounds found in kelakai, such as phenols, flavonoids, anthocyanins, hydroxycinnamic acid, proanthocyanidins, tannins, alkaloids, saponins, carotenoids, and terpenoids, are believed to be produced by the endophytic microbes present in kelakai. Endophytic bacteria can be isolated from the plant, such as leaves, stems, bark, and roots. This research aims to isolate and identify endophytic bacteria from S. palustris. The method used is direct planting. The samples used are the leaves and stems of S. palustris. The results of the research conducted revealed six isolates of endophytic bacteria found in the leaves and stems, namely D1, D2, B1, B2, B3, and B4, which exhibit different colony morphology on the surface and color, while having similar shapes and edges. The results of the Gram staining test on the endophytic bacteria showed negative results and they are rod-shaped. In this study, endophytic bacteria S. palustris were successfully obtained from leaves and stems, which can be further analyzed for their activity.
THE EFFECT OF ORGANIC BIOFERTILIZER FROM BSF LARVAE (Hermetia illucens) AND LOCAL MICROORGANISM ON THE GROWTH OF CAISIM MUSTARD PLANTS Neneng, Liswara; Ngazizah, Febri Nur; Oksal, Efriyana; Pereiz, Zimon; Sari, Nopita Tamara; Aprilia, Indri; Chuchita
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 11 No. 2 (2025): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v11i2.13289

Abstract

One of the solutions developed for utilizing organic materials in agriculture is the use of biological fertilizer. This research is different from previous fertilizer research, where the biofertilizer in this study came from empty palm oil bunches, animal waste by using maggots (BSF larvae, Hermetia illucens) and local microorganisms to degrade them. The aim of this research is to obtain the composition of organic biofertilizer from three wastes that have been processed using maggots and local microorganisms. This research method uses RAL with 12 treatments with 3 repetitions. The results of a study of organic biofertilizer from BSF larvae and a consortium of local microorganisms on white mustard plants (Brasica chinensis) showed that treatment with a combination of animal waste, microbes and BSF larvae showed good results on the growth of white mustard plants. This is proven by the results of measuring soil pH, the highest height of chicory plants and the highest number of leaves compared to other organic biological fertilizer treatments, which were produced at the end of the measurement on day 30, the pH in the treatment with that combination is 4, plant height is 33 cm, and the number of leaves is 20.
The Potential of Ironwood as an Activated Carbon Adsorbent for Heavy Metal Mercury (Hg) Using the Pyrolysis Method Pereiz, Zimon; Oksal, Efriyana; Chuchita, Chuchita; Sylvani, Miranti Maya; Pebriyanto, Yunus
Jurnal Sains dan Terapan Kimia Vol 19, No 1 (2025)
Publisher : Program Studi Kimia, Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jstk.v19i1.20957

Abstract

This study focuses on the utilization of ironwood as an activated carbon adsorbent to remove heavy metal mercury (Hg). The background of the problem includes mercury pollution from various industrial sources and its harmful impacts on the environment and human health. The purpose of this study was to develop an effective method for adsorbing mercury using natural ironwood materials. The research method involves the synthesis of activated carbon through pyrolysis and chemical activation processes, followed by a series of adsorption tests on mercury with variations in pH conditions, contact time, and acid concentration. The research data showed that the optimum adsorption capacity was achieved at a mercury concentration of around 500 ppm, with high adsorption efficiency at pH 1 and a contact time of 80 minutes. The results also showed that the adsorption kinetics followed a second-order model with a rate of 0.017119 g/mg.min. In conclusion, the mercury adsorption process using activated carbon from ironwood followed the Langmuir isotherm model, with an adsorption capacity of 63.036 mg/g, indicating that the adsorbent had been successfully synthesized and had an effective ability to remove mercury.
PENGUJIAN KUALITAS ARANG DARI SERBUK ULIN DENGAN 2 METODE PENGERINGAN Alpian; Segah, Hendrik; Oksal, Efriyana; Chuchita; Pereiz, Zimon; Supriyati, Wahyu
Jurnal Penelitian Hasil Hutan Vol. 42 No. 2 (2024): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jphh.2024.7743

Abstract

Arang merupakan salah satu bahan yang banyak digunakan dalam berbagai industri, terutama sebagai bahan bakar. Pemanfaatan serbuk kayu Ulin berupa limbah dari industri kayu, memiliki potensi untuk diolah menjadi arang berkualitas tinggi melalui proses pirolisis. Penelitian bertujuan untuk menguji kualitas arang yang dihasilkan dari serbuk kayu Ulin dengan metode pirolisis pada suhu asap 80°C selama 8 jam, menggunakan 10 ulangan. Parameter yang diukur meliputi rendemen, kadar air, kadar zat mudah menguap, kadar abu, dan kadar karbon terikat, yang dibandingkan dengan standar SNI 1683:2021. Metode penelitian dilakukan dengan dua perlakuan utama, yaitu serbuk Ulin yang dikeringkan menggunakan gelombang mikro dengan daya 450 Watt selama 1 jam dan serbuk yang dikeringkan dengan metode pengeringan udara. Hasil pengujian menunjukkan bahwa rendemen arang dari serbuk Ulin dengan pengeringan gelombang mikro mencapai 48,57%, sedangkan yang dikeringkan udara mencapai 46,73%. Kadar air pada serbuk Ulin kering udara (5,72%) lebih tinggi dibandingkan dengan serbuk gelombang mikro (3,89%), sementara berturut-turut untuk kadar zat mudah menguap (42,35% dan 50,50%) dan kadar karbon terikat (56,72% dan 48,52%) menunjukkan hasil uji T menunjukkan berpengaruh signifikan. Kadar abu (0,94% dan 0,98%) menunjukkan hasil uji T menunjukkan tidak berpengaruh signifikan. Kesimpulan dari penelitian ini adalah bahwa metode pirolisis pada suhu asap 80°C efektif dalam menghasilkan arang dengan kualitas yang baik dari serbuk kayu Ulin, terutama pada perlakuan pengeringan menggunakan gelombang mikro. Kualitas arang yang dihasilkan memenuhi standar SNI, yaitu kadar air dan kadar abu.  
DECOLORIZATION OF TEXTILE DYES WITH CRUDE LIGNINOLYTIC ENZYMES FROM Coriolopsis caperata Agnestisia, Retno; Karelius, Karelius; Oksal, Efriyana; Nion, Yanetri Asi
Jurnal Bioteknologi dan Biosains Indonesia Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The textile industry is a major contributor to global water pollution, releasing an estimated 280,000 tons of synthetic dyes annually into aquatic ecosystems. These dyes, particularly azo compounds, are often toxic, mutagenic, and resistant to conventional wastewater treatment methods. Microbial enzymatic degradation, especially by white-rot fungi, offers a promising eco-friendly alternative. This study aimed to optimize the production of ligninolytic enzymes—Laccase (Lac), manganese peroxidase (MnP), and lignin peroxidase (LiP)—from Coriolopsis caperata, and assess their efficiency in degrading two azo dyes: Reactive Red 21 (RR21) and Reactive Orange 107 (RO107). The fungus, isolated from the Peat Swamp Forest in Sebangau, Central Kalimantan, was cultured in a modified glucose-peptone medium enriched with veratryl alcohol. The optimization parameters included variations in time, dye concentration, and the addition of hydrogen peroxide (H₂O₂). Enzyme activity was quantified spectrophotometrically, and dye decolorization was assessed over time at different dye concentrations. Among the enzymes, Lac showed the highest activity (4938.05 U/L), followed by LiP (995.26 U/L) and MnP (246.47 U/L). These values notably exceed several previously reported benchmarks for fungal enzyme activity. RO107 demonstrated greater susceptibility to enzymatic degradation, with 83.71% decolorization achieved at 24 hours, while RR21 reached 65.71% at 48 hours. The addition of 1 mM H₂O₂ significantly enhanced decolorization, increasing RR21 and RO107 removal to 95.71% and 99.30%, respectively. These results underscore the oxidative synergy between H₂O₂ and ligninolytic enzymes, particularly LiP and MnP. Overall, the study demonstrates the potential scalability of C. caperata-based enzymatic treatment systems for textile effluent bioremediation, supporting compliance with environmental discharge regulations and contributing to sustainable wastewater management.
Pelatihan dan Pembelajaran Tumbuhan Melalui Herbarium Kering di Kelas 5 SD Negeri Patung Oksal, Efriyana; Wiriatmaja, Nuraini Ulya; Lawrence, Yoel; Zadrax, Adellino; Seda, Ananda Putri; Situmorang, Larissa Kristina T.T.; Sidauruk, Christina; Sianturi, Dody Jhonatan Wilfiez; Manalu, Mely Grace Manalu; Riansyah, Irza; Kibtiyah, Maryatul; Gloria, Meilina; Ayu, Yulia Agustina; Maulida, Maulida; Seprianto, Seprianto
Journal of Appropriate Technology for Community Services Vol. 6 No. 2 (2025)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jattec.vol6.iss2.art4

Abstract

This service aims to increase the understanding of grade 5 students at SD Negeri Patung about plant diversity through training and introduction to the herbarium. The problem faced is students' lack of knowledge about plant types and the importance of conservation. The methods used include the first stage of socialization of herbarium activities and the second stage of dry herbarium training. The results of the service show an increase in student's knowledge about plant classification, as well as skills in collecting and preserving plant specimens. As many as 80% of students showed high enthusiasm and were able to explain the process of making a herbarium well. In conclusion, this training not only increases students' knowledge about plants but also fosters a sense of love for the environment. The use of herbarium as a learning tool has proven effective in introducing the concept of biodiversity to the younger generation. It is hoped that this program can be implemented on an ongoing basis to support environmental education in elementary schools.