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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Fahrul Huyop
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Agriculture, Biological Sciences & Forestry Environmental Science

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The Genetic Organisation and Control of Putative Dehalogenase Gene Expression in Bacillus megaterium WSH-002: Putative Dehalogenase Gene Expression in Bacillus megaterium Luqman Arif Zulkarnain; Fahrul Huyop
Journal of Tropical Life Science Vol. 13 No. 2 (2023)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.13.02.15

Abstract

Dehalogenase-producing bacterium has been extensively studied due to their ability to reduce pollution in the environment. A previous study reported that Bacillus megaterium WSH-002 contains a putative haloacid dehalogenase type II gene, therefore, the presence of other genes associated with the dehalogenase regulatory gene function and uptake of halogenated compounds are expected. In the Bacillus megaterium WSH-002 whole genome, type II dehalogenase (DehWSH002) and two other genes related to dehalogenase regulatory and haloacid uptake genes were identified suggesting its ability to control the expression of putative dehalogenase(s) and the uptake of halogenated compounds into the cells. The phylogenetic analysis showed that DehWSH002 shared common features with DehLBHS1 of Bacillus megaterium strain BHS1 and Had protein of Bacillus megaterium strain ATCC12872/QMB1551. The study concluded that the genome of Bacillus megaterium WSH-002 contains a dehalogenase gene designated as dehWSH002 that is useful for biodegradation. In addition, further investigation of the adjacent genes suggested the presence of dehalogenase regulatory gene (dehR) and an uptake gene (dehP) in a single genetic organisation.
The Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management: The Dietary Supplements in T2DM Management Musafer, Karar Nadhum Jawad; Kamal Mohammed, Amera; Chobok, Ali Sabah; AL-Mousawi, Masar Riyadh Rashid; Fahrul Huyop; Tahreer M. Al-Thuwaini
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.01

Abstract

A chronic metabolic condition, type 2 diabetes mellitus (T2DM) typically presents with hyperglycemia owing to elevated tissue insulin resistance or inadequate insulin release. In addition to the use of pharmaceutical agents and lifestyle changes for the management of T2DM, supplementation with various vitamins and minerals has also been proven to be of benefit. The objective of the present research was to establish the effectiveness of vitamin B12, vitamin C, selenium, and chromium as adjunctive therapy given over 120 days in diminishing insulin resistance. In total, 32 individuals (16 men and 16 women) living with diabetes were enrolled in the study. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), serum insulin concentrations, and homeostatic model assessment of insulin resistance (HOMA-IR) were quantified at baseline and on day 120 of supplementation. Mean FBG and HbA1c levels and insulin concentrations all decreased, i.e. 185.11 ± 22.67 mg/dL vs. 163.57 ± 19.31 mg/dL (P = 0.02), 8.47 ± 0.52% vs. 7.80 ± 0.48% (P = 0.003), and 23.15 ± 3.87 vs. 15.85 ± 1.46 (P = 0.02), respectively. HOMA-IR values remained unchanged. The association between therapy and clinical features was examined using logistic regression analysis. In the subjects with T2DM, FBG, and HbA1c levels were diminished by a factor of 2. It was concluded that vitamin and mineral supplementation was of benefit with respect to glycemic parameters. Nevertheless, high-quality evidence that supports the efficacy of such substances to improve glucose homeostasis and insulin resistance in individuals with T2DM in a clinical setting is lacking
The Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management: The Dietary Supplements in T2DM Management Musafer, Karar Nadhum Jawad; Kamal Mohammed, Amera; Chobok, Ali Sabah; AL-Mousawi, Masar Riyadh Rashid; Fahrul Huyop; Tahreer M. Al-Thuwaini
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.01

Abstract

A chronic metabolic condition, type 2 diabetes mellitus (T2DM) typically presents with hyperglycemia owing to elevated tissue insulin resistance or inadequate insulin release. In addition to the use of pharmaceutical agents and lifestyle changes for the management of T2DM, supplementation with various vitamins and minerals has also been proven to be of benefit. The objective of the present research was to establish the effectiveness of vitamin B12, vitamin C, selenium, and chromium as adjunctive therapy given over 120 days in diminishing insulin resistance. In total, 32 individuals (16 men and 16 women) living with diabetes were enrolled in the study. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), serum insulin concentrations, and homeostatic model assessment of insulin resistance (HOMA-IR) were quantified at baseline and on day 120 of supplementation. Mean FBG and HbA1c levels and insulin concentrations all decreased, i.e. 185.11 ± 22.67 mg/dL vs. 163.57 ± 19.31 mg/dL (P = 0.02), 8.47 ± 0.52% vs. 7.80 ± 0.48% (P = 0.003), and 23.15 ± 3.87 vs. 15.85 ± 1.46 (P = 0.02), respectively. HOMA-IR values remained unchanged. The association between therapy and clinical features was examined using logistic regression analysis. In the subjects with T2DM, FBG, and HbA1c levels were diminished by a factor of 2. It was concluded that vitamin and mineral supplementation was of benefit with respect to glycemic parameters. Nevertheless, high-quality evidence that supports the efficacy of such substances to improve glucose homeostasis and insulin resistance in individuals with T2DM in a clinical setting is lacking
Co-Authors AL-Mousawi, Masar Riyadh Rashid Chobok, Ali Sabah Kamal Mohammed, Amera Luqman Arif Zulkarnain Musafer, Karar Nadhum Jawad Tahreer M. Al-Thuwaini