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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Medical Journal of Indonesia
Musafer, Karar Nadhum Jawad
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Agriculture, Biological Sciences & Forestry Environmental Science Medicine & Pharmacology

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The Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management: The Dietary Supplements in T2DM Management Musafer, Karar Nadhum Jawad; Kamal Mohammed, Amera; Chobok, Ali Sabah; AL-Mousawi, Masar Riyadh Rashid; Fahrul Huyop; Tahreer M. Al-Thuwaini
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.01

Abstract

A chronic metabolic condition, type 2 diabetes mellitus (T2DM) typically presents with hyperglycemia owing to elevated tissue insulin resistance or inadequate insulin release. In addition to the use of pharmaceutical agents and lifestyle changes for the management of T2DM, supplementation with various vitamins and minerals has also been proven to be of benefit. The objective of the present research was to establish the effectiveness of vitamin B12, vitamin C, selenium, and chromium as adjunctive therapy given over 120 days in diminishing insulin resistance. In total, 32 individuals (16 men and 16 women) living with diabetes were enrolled in the study. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), serum insulin concentrations, and homeostatic model assessment of insulin resistance (HOMA-IR) were quantified at baseline and on day 120 of supplementation. Mean FBG and HbA1c levels and insulin concentrations all decreased, i.e. 185.11 ± 22.67 mg/dL vs. 163.57 ± 19.31 mg/dL (P = 0.02), 8.47 ± 0.52% vs. 7.80 ± 0.48% (P = 0.003), and 23.15 ± 3.87 vs. 15.85 ± 1.46 (P = 0.02), respectively. HOMA-IR values remained unchanged. The association between therapy and clinical features was examined using logistic regression analysis. In the subjects with T2DM, FBG, and HbA1c levels were diminished by a factor of 2. It was concluded that vitamin and mineral supplementation was of benefit with respect to glycemic parameters. Nevertheless, high-quality evidence that supports the efficacy of such substances to improve glucose homeostasis and insulin resistance in individuals with T2DM in a clinical setting is lacking
Association between high serum levels of soluble vascular cell adhesion molecule-1 and obesity in women Musafer, Karar Nadhum Jawad; Mohammed, Amera Kamal; Al-Thuwaini, Tahreer Mohammed; Huyop, Fahrul; Bradosty, Sarwan Wasman
Medical Journal of Indonesia Vol. 34 No. 2 (2025): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257801

Abstract

BACKGROUND Obesity and metabolic disorders are associated with persistent low-level inflammation connected to soluble vascular cell adhesion molecule-1 (sVCAM-1). Recent research highlights its connection to endothelial dysfunction in female obesity. This study aimed to investigate the relationship between sVCAM-1 levels and obesity-related risk factors in women from Kirkuk City, Iraq. METHODS A case-control study was conducted on 90 women aged 20–50, including 43 participants with obesity and 47 healthy controls. Blood samples were collected, processed, and analyzed to measure various biochemical markers, including sVCAM-1. Logistic regression analysis was utilized to examine the association between sVCAM-1 levels and obesity-related parameters. Correlation analysis was performed to assess associations with body mass index (BMI). Statistical analysis was conducted using SPSS software version 23.0. RESULTS Correlation analysis revealed that BMI was significantly correlated with alanine aminotransferase (r = 0.37, p = 0.011), uric acid (r = 0.30, p = 0.04), insulin (r = 0.37, p = 0.01), homeostatic model assessment of insulin resistance (r = 0.47, p = 0.002), and sVCAM-1 (r = 0.53, p = 0.001). These results suggest that elevated sVCAM-1 levels may serve as predictive biomarkers for increased insulin resistance in obese individuals. These findings indicate that sVCAM-1 is strongly linked to female obesity and insulin resistance. CONCLUSIONS This study confirms the potential use of sVCAM-1 as a prognostic biomarker for obesity-related metabolic disturbances and its role in identifying individuals with a higher risk of developing insulin resistance.
The Impact of Some Vitamins and Minerals Supplements on Type 2 Diabetes (T2DM) Management: The Dietary Supplements in T2DM Management Musafer, Karar Nadhum Jawad; Kamal Mohammed, Amera; Chobok, Ali Sabah; AL-Mousawi, Masar Riyadh Rashid; Fahrul Huyop; Tahreer M. Al-Thuwaini
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.01

Abstract

A chronic metabolic condition, type 2 diabetes mellitus (T2DM) typically presents with hyperglycemia owing to elevated tissue insulin resistance or inadequate insulin release. In addition to the use of pharmaceutical agents and lifestyle changes for the management of T2DM, supplementation with various vitamins and minerals has also been proven to be of benefit. The objective of the present research was to establish the effectiveness of vitamin B12, vitamin C, selenium, and chromium as adjunctive therapy given over 120 days in diminishing insulin resistance. In total, 32 individuals (16 men and 16 women) living with diabetes were enrolled in the study. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), serum insulin concentrations, and homeostatic model assessment of insulin resistance (HOMA-IR) were quantified at baseline and on day 120 of supplementation. Mean FBG and HbA1c levels and insulin concentrations all decreased, i.e. 185.11 ± 22.67 mg/dL vs. 163.57 ± 19.31 mg/dL (P = 0.02), 8.47 ± 0.52% vs. 7.80 ± 0.48% (P = 0.003), and 23.15 ± 3.87 vs. 15.85 ± 1.46 (P = 0.02), respectively. HOMA-IR values remained unchanged. The association between therapy and clinical features was examined using logistic regression analysis. In the subjects with T2DM, FBG, and HbA1c levels were diminished by a factor of 2. It was concluded that vitamin and mineral supplementation was of benefit with respect to glycemic parameters. Nevertheless, high-quality evidence that supports the efficacy of such substances to improve glucose homeostasis and insulin resistance in individuals with T2DM in a clinical setting is lacking
Co-Authors AL-Mousawi, Masar Riyadh Rashid Al-Thuwaini, Tahreer Mohammed Bradosty, Sarwan Wasman Chobok, Ali Sabah Fahrul Huyop Huyop, Fahrul Kamal Mohammed, Amera Mohammed, Amera Kamal Tahreer M. Al-Thuwaini