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UJI TOKSISITAS AKUT SENYAWA ASAM p-METOKSISINAMAT YANG DISINTESIS DARI ETIL p-METOKSISINAMAT Sara Nurmala; Indah Zahara
JURNAL KIMIA MULAWARMAN Vol 19 No 2 (2022)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v19i2.901

Abstract

Kencur (Kaempferia galanga L.) is a plant that grows in Indonesia and is often used as a traditional spice. The main content of Kencur is ethyl p-methoxycinamic has a mild level of toxicity. Hydrolysis results from Ethyl p-methoxycinamic namely p-methoxycinamic acid have been widely studied as having antibacterial activity against S. aureus with MIC of 125 ppm. P-methoxycinamic acid has anti-inflammatory activity, topical anti-inflammatory power of 8.7% p-methoxycinamic acid based on molar equality with 1% Na-diclofenac. Cinnamic acid compounds have greater potential as an inhibitor of cervical cancer cells compared to methyl cinnamon because they have more hydrogen bonds. Hydrolysis of ethyl p-methoxycinamic to p-methoxycinamic acid has been carried out, then identification tests have been carried out covering the melting distance obtained values ​​of 172–173ºC. The results of TLC analysis with the mobile phase of methanol: acetone (2: 1) p-methoxycinamic acid compound gave an Rf value of: 0.67. The results of infrared spectrum analysis of hydrolysis compounds provide information on the presence of specific functional groups, namely carbonyl groups of acids (C = O) which are shown by the absorption band at wave number 1690.49 cm-1. Hydrogen bonding in carboxylic acid dimers weakens the C = O bond, resulting in absorption at lower wave numbers. In this spectrum CO groups of acids are shown at absorption of 1029.92 cm-1, aromatic C = C groups are shown by uptake at wave numbers 1602.74 cm-1 and 1627.81 cm-1, while bands at wave number 828.37 cm-1 indicates the presence of para-substituted aromatic nuclei. Acute toxicity test of p-methoxycinamic acid compound which was carried out in a span of 24 hours showed that p-methoxycinamic acid had a moderate level of toxicity.
The Effect of Hand Washing Soap with Soursop Leaf and Guava Leaf Extract on Staphylococcus aureus Bacteria Indah Zahara; Agustina Nina
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.1969

Abstract

This study tested a handwash formulation containing a combination of soursop leaf extract and guava leaf extract as active ingredients. These two extracts are known to have antibacterial properties, and the study results show that the formulated handwash has physical and chemical properties according to SNI standards. The formulated handwash has a brown color with a distinctive aroma of extract, homogeneous, pH 10.00, foam height of 100 mm, and viscosity ranging from 700-20,000 cPs with pseudoplastic flow properties. In addition, handwashing with a combination of soursop and guava leaf extract also showed significant antibacterial activity against Staphylococcus aureus bacteria. The average diameter of the inhibition zone for handwash with different formulas showed powerful results. Thus, combining soursop leaf extract and guava leaf extract can be an effective alternative in maintaining hand hygiene and preventing disease transmission through contact with microorganisms on the hands. Further research needs to be done to optimize the use of natural ingredients such as soursop leaf extract and guava leaf extract in health care products to provide more comprehensive benefits to maintain the health and cleanliness of the body. Abstrak: Penelitian ini menguji formulasi handwash yang mengandung kombinasi ekstrak daun sirsak dan ekstrak daun jambu biji sebagai bahan aktif. Kedua ekstrak ini diketahui memiliki sifat antibakteri, dan hasil penelitian menunjukkan bahwa handwash yang diformulasikan memiliki sifat fisik dan kimia yang sesuai dengan standar SNI. Handwash yang diformulasikan memiliki sediaan berwarna cokelat dengan aroma khas ekstrak, homogen, pH 10,00, tinggi busa 100 mm, dan viskositas berkisar antara 700-20.000 cPs dengan sifat alir pseudoplastis. Selain itu, handwash dengan kombinasi ekstrak daun sirsak dan ekstrak daun jambu biji juga menunjukkan aktivitas antibakteri yang signifikan terhadap bakteri Staphylococcus aureus. Diameter rata-rata zona hambat untuk handwash dengan formula yang berbeda menunjukkan hasil yang sangat kuat. Dengan demikian, kombinasi ekstrak daun sirsak dan ekstrak daun jambu biji dapat menjadi alternatif efektif dalam menjaga kebersihan tangan dan mencegah penularan penyakit melalui kontak mikroorganisme pada tangan. Penelitian lebih lanjut perlu dilakukan untuk mengoptimalkan penggunaan bahan alami seperti ekstrak daun sirsak dan ekstrak daun jambu biji dalam produk perawatan kesehatan, guna memberikan manfaat yang lebih luas dalam upaya menjaga kesehatan dan kebersihan tubuh.