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All Journal Journal Pharmasci (Journal of Pharmacy and Science) Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya
Evi Puspita Sari
Institut Teknologi Sains dan Kesehatan Insan Cendekia Medika Jombang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Korelasi Kadar HbA1c dengan C-Reactive Protein Pasien Diabetes Melitus Tipe 2 Evi Puspita Sari; Sri Sayekti
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 4 No 1 (2023): Juni 2023
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v4i1.102

Abstract

Diabetes melitus merupakan penyakit metabolik dengan karakteristik hiperglikemia. Hiperglikemia kronis dapat menginduksi stres oksidatif dan peradangan dalam tubuh. HbA1c merupakan salah satu parameter yang digunakan untuk menilai kontrol glikemik pasien diabetes. Berbagai penelitian menunjukkan bahwa penanda inflamasi dalam darah seperti CRP meningkat secara signifikan pada pasien diabetes melitus. Penelitian ini bertujuan mengetahui adanya hubungan antara kadar HbA1C dengan C-reactive Protein (CRP) pada pasien diabetes melitus tipe 2. Jenis penelitian ini adalah penelitian analitik dengan rancangan cross sectional. Jumlah subjek penelitian yaitu 24 pasien diabetes melitus tipe 2 yang memenuhi kriteria. Kadar HbA1c ditentukan dengan metode Turbidimetric Inhibition Immunoassay. Kadar CRP diperiksa menggunakan metode aglutinasi latex. Hasil uji korelasi dengan Rank Spearman test didapatkan nilai p=0,171, r= 0,218 sehingga dapat disimpulkan tidak ada hubungan yang signifikan antara kadar HbA1c dengan CRP pada pasien diabetes melitus tipe 2.
Stability of Serotonin Transporter Essential Amino Acid Complex with Curcumin and Demethoxycurcumin Compounds as Antidepressant Candidates Based on In Silico Test: Stabilitas Kompleks Asam Amino Esensial Pengangkut Serotonin dengan Senyawa Curcumin dan Demethoxycurcumin sebagai Kandidat Antidepresan Berdasarkan Uji In Silico Farach Khanifah; Evi Puspita Sari; Gerry Nugraha
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 9 No. 1 (2024): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v9i1.426

Abstract

A Depression is a mental problem that is common in all communities, including teenagers. It is estimated that 10- 20% of teenagers in the world experience mental health problems. Turmeric at a dose of 560mg/KgBW was shown to be effective as an antidepressant in Wistar rats (rattus norvegicus). Computers offer in silico test methods as a complement to in vitro and in vivo methods which are commonly used in the process of discovering and developing the biological activity of chemical compounds or natural materials as drug candidates. The research results show that MD simulations on the serotonin transporter complex protein with the ligand Demethoxycurcumin are more stable than curcumin and fluvoxamine. The results of identifying the molecular dynamics determinant of binding with the native ligand are amino acid SER336 and the reference ligand is amino acid SER438.
Co-Authors Farach Khanifah Gerry Nugraha Sri Sayekti