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Efizal Efizal, Efizal
Badan Pengawas Obat dan Makanan RI

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Uji Aktivitas Penghambatan Enzim A-Glukosidase Daun Kalanchoe Pinnata Pers Efizal, Efizal; Soemiati, Atiek; Hanafi, M; Dwiyanti, Indah
Majalah Ilmu Kefarmasian Vol. 4, No. 1
Publisher : UI Scholars Hub

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Abstract

The study of inhibitory activity against the a-glucosidase enzyme of Kalanchoe pinnata Pers. leaves has been carried out. In vitro, the methanol extract, n-hexane fraction, ethyl acetate fraction and methanol-water (1:1) fraction inhibited a-glucosidase enzyme activities with IC50 value 72.8, 982.6, 194.6 and 293.8 ug/mL, respectively. In vivo, the study was conducted in normal ddY mice by using oral glucose tolerance test. The administration of methanol extract dose 0.5, 1.0 g/kg of body weight and ethyl acetate fraction dose 1.0 g/kg of body weight can suppress the blood glucose level at 30 min significantly (p<0.05) if compared with control after oral administration of sucrose (3 g/kg of body weight), and their activity were similar with acarbose 0.01 g/kg of body weight (p>0.05).
Co-Authors Atiek Soemiati Indah Dwiyanti, Indah M Hanafi