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All Journal Jurnal Ilmu Ternak Veteriner
Ari Sulistyo Wulandari
Research Center for Applied Zoology, National Research and Innovation Agency (BRIN)
Veterinary

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The 84-bp Indel Polymorphism of The Sterol Regulatory Element-Binding Protein 1 (SREBP1) Gene in Several Cattle Breeds in Indonesia Saiful Anwar; Widya Pintaka Bayu Putra; Isyana Khaerunnisa; Ari Sulistyo Wulandari; Koko Wisnu Prihatin; Sutikno Sutikno
Jurnal Ilmu Ternak dan Veteriner Vol 28, No 2 (2023): June 2023
Publisher : Indonesian Center for Animal Research and Development (ICARD)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14334/jitv.v28i2.3046

Abstract

Sterol regulatory element-binding protein 1 (SREBP1) gene is a gene that encodes SREBP1, a family of transcription factors that have a key role in lipid homeostasis as well as fatty acid metabolisms. The present study aimed to detect the 84-bp indel polymorphism in the intron 5 of the SREBP1 gene (84-bp indel) in several cattle breeds in Indonesia.  A total of 740 cattle of six breeds (Limousin, Simmental, Holstein-Friesian, Bali, Sumbawa, and Pasundan) from two National Artificial Insemination Centers (NAICs) and smallholder farmers were used in this study. The detection of 84-bp indel polymorphism was performed using the polymerase chain reaction (PCR) method and visualized through a gel agarose electrophoresis system. The study showed that the L allele (insertion-type) was common and is fixed in Holstein-Friesian, Bali, and Sumbawa cattle (1.00). Meanwhile, the S allele (deletion-type) was found in Limousin, Simmental, and Pasundan cattle with a frequency of 0.24, 0.16, and 0.01, respectively. The presence of the S allele in Pasundan cattle was only found in the form of the heterozygous LS genotype (0.03). In conclusion, the 84-bp indel of the SREBP1 gene was found to be polymorphic in Limousin, Simmental, and Pasundan cattle, but monomorphic in Holstein-Friesian, Bali, and Sumbawa cattle.
Co-Authors Isyana Khaerunnisa Koko Wisnu Prihatin Saiful Anwar Sutikno Sutikno Widya Pintaka Bayu Putra