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Vriezka Mierza
Universitas Singaperbangsa Karawang, Jl. HS. Ronggo Waluyo, Telukjambe Timur, Karawang, Jawa Barat, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Standarisasi Senyawa Diosgenin Pada Tumbuhan : Review Artikel Vriezka Mierza; Anisa Fauziah; Riani Riani; Sulastri Sulastri; Siti Farikha; Faizal Auladi Rivianto
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (372.061 KB) | DOI: 10.36490/journal-jps.com.v6i1.26

Abstract

Diosgenin is a steroid sapogenin composed of a hydrophilic sugar with a hydrophobic steroid aglycone which functions as a starting material in the production of steroid drugs and hormones. Pharmacologically, diosgenin has been widely used as a treatment for leukemia, inflammation, hypercholesterolemia, and cancer. Diosgenin compounds are contained in plants such as abutilon indicum L, Coctus speciosus, tubers of Dioscorea spp, and fenugreek seeds. In order to guarantee the quality of the product, the active compounds must be standardized, so that uniform raw materials can be obtained and the pharmacological effects of these plants can be guaranteed. This article review was carried out by means of literature studies using secondary data in the form of journals and articles to standardize diosgenin compounds in several plants using high performance liquid chromatography (HPLC), high performance thin layer chromatography (HPTLC), ultra high performance liquid chromatography (UPLC) methods. and thin layer chromatography (TLC).
ANALISIS BERBAGAI METODE IDENTIFIKASI ISOFLAVON: LITERATUR REVIEW Vriezka Mierza; Fitri Aida; Hajar Hartati; Herdiana Verliani; Nisa Alifia Zahra; Rika Valensia
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.22 KB) | DOI: 10.36490/journal-jps.com.v6i1.28

Abstract

Isoflavone is included in the phytoestrogens, a natural plant substance with a structure similar to 17-β-estradiol. It can bind to estrogen receptors so that isoflavones can prevent or slow down forms of cancer related to Alzheimer's hormones, osteoporosis, and others. Isoflavones are also included in the flavonoids found in fruits such as berries, grapes and are most abundant in soybeans and other nuts. From the literature study that has been conducted, it was found that there are several methods for identifying isoflavone compounds, including HPLC/HPLC, TLC, UV-Vis Spectrophotometry, Mass Spectrophotometry, and others. Of the many types of isoflavones that exist, the most commonly identified isoflavones are genistein and daidzein, which can be found in samples of soybeans, soy milk, and processed tempeh. The isoflavone content identified by each researcher differs in terms of the quantity and type of isoflavone content. This is because in identifying isoflavones, there are factors that influence them. The duration of fermentation has an effect because it is related to the presence of dissolved compounds during the fermentation process, which results in differences in the quantity of isoflavones, besides that the reactive and easily oxidized nature of isoflavones causes isoflavones to bind to other compounds to form new unknown compounds so that isoflavones are no longer identified.
Co-Authors Anisa Fauziah Faizal Auladi Rivianto Fitri Aida Hajar Hartati Herdiana Verliani Nisa Alifia Zahra Riani Riani Rika Valensia Siti Farikha Sulastri Sulastri