Garuda - Garba Rujukan Digital

Sudewi Sudewi

Fakultas Farmasi, Universitas Tjut Nyak Dhien, Medan, Sumatera Utara, Indonesia.

Author-ID : 6257132

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Formulasi Sediaan Ekstrak Etanol Kulit Buah Alpukat (Persea Americana Mill.) Sebagai Krim Alas Bedak Hamdhani Hamdhani; Muharni Saputri; Sudewi Sudewi; Linda Margata
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Avocado (Persea americana Mill.) is a plant that is widely grown in Indonesia. Peel avocado is known to contain secondary metabolites such as flavonoids which are useful as antioxidants. This study aims to determine the peel of avocado (Persea americana Mill.) in the form of ethanol extract can be formulated into a foundation cream preparation which at a certain concentration has antioxidant activity. Method; The study was conducted using an experimental method, using peel avocado test material (Persea americana Mill.) processed by maceration using 96% ethanol extract formulated into a foundation cream preparation in a concentration of 1.5%; 2%; 2.5%; and blank. Examination of the physical quality of the preparation includes homogeneity test, pH test, viscosity test, stability test, irritation test, moisture test and antioxidant activity test. Result; The results showed that the yield of peel avocado (Persea americana Mill.) was 12.99%. All formulations met the requirements of the gel evaluation test with a pH range of 6.0-6.5. After doing the cycling test, it was 5.9-6.2. The viscosity results are 15,250-20,050 mPa.S. All formulations are homogeneous and stable. Formulation 3 has an IC50 value of (54.74µg/mL) in the "strong" antioxidant category and has a % recovery value of 67.23%.

Formulasi sediaan body lotion dari ekstrak etanol buah bit (Beta vulgaris L.) sebagai pelembab kulit dan antioksidan Tri Putri Ananda; Yessi Febriani; Sudewi Sudewi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.51

Background; Antioxidants are molecules that can prevent cell damage by free radicals. Beets (Beta vulgaris L.) are known to contain flavonoids which are antioxidants. This study aims to examine the antioxidant activity and skin moisturizing effect without skin irritation in a product formulated as a body lotion from the ethanol extract of beets (Beta vulgaris L.) at a certain concentration. Methods; This research was conducted using an experimental method using beetroot (Beta vulgaris L.) test material obtained by soaking 96% ethanol extract made in body lotion preparations with concentrations of 1.5%, 2%, 2.5% and blank samples. Sample and preparation tests included phytochemical screening, homogeneity test, inoculum pH test, emulsion type test, inoculum stability test, irritation test, water content test and antioxidant activity test. Result; The results showed that beet-based body lotion (Beta vulgaris L.) was a homogeneous preparation with an M/A emulsion and had a pH range immediately after preparation of 6.2 - 6.3 and a pH after cycle test was 6.2 - 6.3. Formula with a concentration of 2.5% (F3) is able to provide moisture in the wet category with a recovery rate of 27.74% lower than similar hand lotions that are applied to wet areas with a recovery rate of 28.18%. The ethanol extract of beets at a concentration of 2.5% (F3) had an IC50 valueof 118.101 µg/mL which indicated a moderate antioxidant class, while the ethanol extract of beets had an IC50 valueof 36.869 µg/mL which was classified as a very strong antioxidant. All body compositions based on ethanol extract of beetroot do not irritate the skin

studi penggunaan pewarna kopigmentasi biji kesumba keling (Bixa orellana L.) Dan Angkak Merah Dalam Formulasi Suspensi Parasetamol Salman Salman; Sudewi Sudewi; Jazilul Amira; Meutia Indriana
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.64

Background; Annatto seeds (Bixa orellana L.) is a plant originating from the Americas, which is widely cultivated in tropical and subtropical areas. Red yeast rice is white rice that has undergone a fermentation process from rice and mold (Monascus purpereus). This study aims to determine the copigmentation of annatto seeds (Bixa orellana L.) and red yeast rice in the form of ethanol extract that can be formulated as a dye into paracetamol suspension which at certain concentrations can produce colors that meet the requirements and are able to provide color stability. Methods; His study used an experimental method, using the test material of annatto seeds (Bixa orellana L.) and red yeast rice with a ratio of 1:2 using maceration method using 96% ethanol solvent, formulated into paracetamol suspension preparations with concentrations of 0.25%, 0.50% , 0.75%, as well as blanks. Examination of the physical quality of the preparation includes, organoleptic examination, determination of the pH of the preparation, observation of the stability of the preparation against storage, and viscosity test. Result; The results showed that the seeds of annatto seeds (Bixa orellana L.) and red yeast in the form of ethanol extract could be formulated as a dye into the preparation of paracetamol suspension. Copigmented paracetamol suspension preparations of ethanol extract of annatto seeds (Bixa orellana L.) seeds and red yeast rice with a ratio of 1:2 are stable preparations and have a pH range of 4.1-4.4 and pH after cycling test 4.0-4.3 . Has a different color for each concentration contained with a viscosity of 102.0-136.0 dPa.s. The preparation of paracetamol suspension of formula I with a concentration of 0.25% produces a red color (+), the preparation of formula II with a concentration of 0.50% produces a red color (++), the preparation of formula III with a concentration of 0.75% produces a red color (++ +) and white blank preparations.

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