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All Journal International Journal of Public Health Science (IJPHS) Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Hari Hendarto
Department Of Internal Medicine, Faculty Of Medicine And Health Sciences, Syarif Hidayatullah Islamic State University, Ciputat, Indonesia
Health Professions Immunology & microbiology Neuroscience

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Cinnamomum burmannii improves insulin serum level in the normal obese subjects : preliminary study Hari Hendarto; Flori R Sari; Chris Adhyanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.179 KB) | DOI: 10.19106/JMedSci005001201808

Abstract

Obesity is characterized with excessive accumulation of the body fat which occurs whenthe energy intake exceeds the expenditure. It is routinely associated with insulin resistanceand hyperinsulinemia. Additionally, suppressing insulin level protects female mice fromweight gaining. Cinnamon [Cinnamomum burmannii (Ness) Bl. Cortex] suppresseshyperinsulinemia condition in the type 2 diabetic rat suggesting the possible beneficial itsrole in the obesity. We aimed to investigate the effect of Cinnamon extract in the normalobese subjects. In this preliminary cross-over clinical trial, 24 normal obese subjectswere recruited and divided randomly into two groups i.e. treatment and placebo. Twograms of the cinnamon extract were given twice daily for 56 days in the treatment group.Normal obese subjects given placebo were allocated as the placebo group. After thetreatment, each of the group ran a one month run-in period, then the groups were crossoveredfor the next 56 days. Body mass index (BMI), insulin serum level, cholesterol andtriglyceride plasma levels were measured at the beginning and at the end of the study.No diet restriction nor exercise intervention was given during the study. At the end of thestudy, BMI in the treatment group (58%) were slightly reduced when compared to theplacebo group (33%), however, it was not significantly different (p>0.05). Moreover,significantly reduction in the insulin serum level was observed in 63% subject in thetreatment group compared to 33% subject in the placebo group (p < 0.05). Additionally,there were no significant differences of cholesterol and triglyceride plasma level observedin the both group. In conclusion, cinnamon extract may give beneficial role in the normalobese subjects by suppressing the serum insulin level. Further studies are required toelucidate the specific role of cinnamon in preventing weight gain.
Adverse events following immunization of mRNA-1273 (Moderna) booster vaccine in clerkship students Hendarto, Hari; Akbar, Femmy Nurul; Nasir, Narila Mutia; Wulandari, Endah; Adlani, Hadianti
International Journal of Public Health Science (IJPHS) Vol 13, No 2: June 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i2.23701

Abstract

Two-dose primary vaccine administration was the best strategy to reduce the prevalence and severity of COVID-19. Improved immunity and antibody response to the new variant virus by administering a booster vaccine is needed. Health workers are the main priority for administering the mRNA-1273 (Moderna) booster vaccination in Indonesia. This vaccine has high effectiveness, and safety, however, data and evaluation of adverse events following immunization (AEFI) is required. This study aimed to determine the AEFIs of mRNA-1273 booster vaccination in clinical clerkship students as an early adult age group. The research design was a repeated cross-sectional study using purposive sampling technique. There were 214 subjects who met the requirements. Subject filled out an online questionnaire containing evaluation of AEFIs. The most local AEFIs symptoms were pain at the injection site (79.0%), while the common systemic symptoms were headache, drowsiness, weakness, and fever (37.4%; 26.2%; 9.8%; 9.3%). Most AEFIs were felt within 30 minutes to three days. No respondents required hospitalization, experienced anaphylactic shock, became disabled, or died. The AEFIs did not have a significant relationship with gender, history of allergies, co-morbidities, or history of COVID-19. This information is used as a preventive or educational effort to support implementation vaccine in Indonesia.
Co-Authors Adlani, Hadianti Chris Adhyanto Dante S Harbuwono, Dante S Em Yunir, Em Endah Wulandari Femmy Nurul Akbar Flori R Sari Imam Subekti Laurentius A Pramono, Laurentius A Nasir, Narila Mutia