Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Alami Journal (Alauddin Islamic Medical) Journal
Rahmawati Minhajat, Rahmawati
Unknown Affiliation
Education Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Efek Simvastatin terhadap Urin dan Jaringan Buli-Buli pada Tikus Model Sistitis Interstisial Akut yang Diinduksi Protamin Sulfat Hasanuddin, Abdi Dzul Ikram; Minhajat, Rahmawati; Muis, Mirna
Alami Journal (Alauddin Islamic Medical) Journal Vol 7 No 2 (2023): JULY
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/alami.v7i2.39062

Abstract

The pathophysiology of interstitial cystitis (IC) is complicated and related to statin drug use without any established underlying mechanisms. This study used a rat model of acute IC caused by protamine sulfate to examine the effects of simvastatin on bladder and urine macro-tissue after simvastatin treatment. There were 12 adult female Wistar rats. Simvastatin 10 mg/kgBB + protamine sulfate group (S10P), Simvastatin 50 mg/kgBB + protamine sulfate group (S50P), and Placebo + Protamin Sulfate group (KP) were the three groups (each n=4) into which the subjects were grouped. Simvastatin or placebo CMC 0,5% was administered orally to all animals for 30 days, followed by an intravesical protamine sulfate (10 mg/ml) instillation procedure. All animals were gathered three days after intravesical therapy to collect urine samples and bladder tissue. Simvastatin group participants' levels of hematuria were significantly higher than those of the control group (p = 0.03). Only relative bladder weight was substantially higher in the S50P group than in the control group (p=0.032). Simvastatin group members did not substantially vary from the control group regarding bladder macroscopic oedema and haemorrhage. To conclude, simvastatin may influence the condition of tissue hypervascularization and hypertrophy, contributing to the chronicity of acute interstitial cystitis.
Analysis of Causes, Maternal And Perinatal Outcomes In Third Trimester Pregnant Women With Normocytic Anemia Sharief, Suchi Avnalurini; Minhajat, Rahmawati; Bukhari, Agussalim
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 1 January 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i1.2311

Abstract

Abstract Objective : Analyzing the causes, maternal and perinatal outcomes in third trimester pregnant women. Method :This research is a hybrid study which combines 2 research designs, namely descriptive analytical and observational with a cross sectional study approach to assess laboratory examinations of anemic pregnant women and a cohort to assess maternal & perinatal outcomes in third trimester pregnant women with normocytic anemia. Bivariate analysis was carried out using the chi square test to measure the strength of the relationship between variables. A complete blood count, ferritin, TIBC, serum Fe, reticulocyte and peripheral blood smear were carried out. This research was conducted on third trimester pregnant women with anemia. Results :Of the 50 pregnant women who experienced normocytic anemia, there were (92,0%) mild anemia, (8,0%) moderate anemia and no severe anemia was found. Maternal and perinatal outcomes have a p value <0.05. Most pregnant women in the third trimester have low serum Fe < 37 µ/dL (52,2%) in mild anemia and normal serum Fe 37-148 µ/dL (75%) in moderate anemia, most have low ferritin < 13 ng/ dL in mild anemia (82,6%) and (100%) in moderate anemia, most high TIBC ? 389 µ/dL in mild anemia (87%) and (100%) in moderate anemia, all reticulocyte values ??are high (> 1,50%) in mild and moderate anemia. Conclusion :Chronic diseases and infections were the biggest causes of normocytic anemia in third trimester pregnant women in this study, howeverNormocytic anemia in this study had a picture of serum ferritin and iron that almost resembled microcytic anemia, which was probably caused by iron deficiency, so it was necessary to examine C-Reactive Protein (CRP) as a biomarker/sign of infectious disease.The higher the degree of anemia, the greater the risk of birth problems, which will affect the birth process. Likewise with perinatal outcomes, the higher the degree of anemia, the greater the incidence of LBW and asphyxia in babies. Keywords: Normocytic anemia, pregnancy, maternal and perinatal outcomes, serum Fe, ferritin, TIBC, reticulocytes
Co-Authors Abdi Dzul Ikram Hasanuddin Andi Fachruddin Benyamin, Andi Fachruddin Bukhari, Agussalim Dimas Bayu, Dimas Dina Nilasari, Dina Muis, Mirna Suchi Avnalurini Sharief Syakib Bakri