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All Journal Jurnal Kedokteran Brawijaya Alami Journal (Alauddin Islamic Medical) Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education BEMAS: Jurnal Bermasyarakat Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jambura Medical and Health Science Journal PPSDP International Journal of Education Medic Nutricia : Jurnal Ilmu Kesehatan
Abdi Dzul Ikram Hasanuddin
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Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Effect of Simvastatin on Eosinophilic Inflammation of Bladder Tissue in Interstitial Cystitis Rat Model Muhamad Nur Syukriani Yusuf; Abdi Dzul Ikram Hasanuddin; Zuhriana K Yusuf; Trinny Tuna; Nurani Ibrahim; Marshanda Tiara Posumah; Ridho Tianggara
Jurnal Kedokteran Brawijaya Vol. 32 No. 2 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.02.1

Abstract

In the urogenital system, simvastatin is associated with interstitial cystitis adverse effects, but the exact mechanism is not yet clearly defined. This study aims to determine the effect of simvastatin on eosinophilic inflammation of bladder tissue in vivo. Laboratory experimental research design with the post-test only control group using 24 female Wistar rats aged 8-10 weeks were randomly divided into simvastatin 50mg/kg BW (n=12) or placebo carboxymethylcellulose 0.5% (n=12). All groups received treatment through oral gavage for thirty days. After that, each group was divided equally into three subgroups: control rat, day 0 Interstitial Cystitis (IC) rat (IC0), and day 3 IC rat (IC3). Control or IC0 rats each received intravesical instillation of buffered saline or protamine sulfate (PS), respectively, and were terminated immediately less than 3 hours after instillation. The IC3 rats received intravesical PS instillation and were terminated three days post-instillation. The bladder tissue was made in Hematoxylin-Eosin histology preparations. As in previous studies, the results showed successful desquamation of the urothelium after PS instillation. Tissue eosinophil counts were significantly higher in the simvastatin group than in the placebo group in the IC3 model (15.50±5.92 vs. 4.00±2.83, p=0.013). It can be concluded that the mechanism of the adverse effect of simvastatin on bladder tissue is through increased tissue inflammation mediated by eosinophils along with urothelial layer destruction by the protamine sulfate.
Characteristics of Thyroid Neoplasm Patients in the Department of Anatomic Pathology, Aloei Saboe Hospital Trinny Tuna; Nur Hijra Puji Astuti; Sri Andriani Ibrahim; Abdi Dzul Ikram Hasanuddin; Romy Abdul
Jambura Medical and Health Science Journal Vol 2, No 1 (2023): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v2i1.18835

Abstract

Introduction: Thyroid Neoplasm is a tumor originating from the thyroid gland. Thyroid neoplasms encompass both benign and malignant tumors. Thyroid malignancies are among the most frequently encountered malignancies of the endocrine glands. Thyroid neoplasms generally have a relatively good prognosis when detected early. This study aims to determine the characteristics of thyroid neoplasm patients in the Department of Anatomic Pathology, Aloei Saboe Hospital.Method: This study is descriptive research using secondary data from medical records. Data was collected using a total sampling technique with a sample size of 58 patients. The study was conducted in the Department of Anatomic Pathology, Aloei Saboe Hospital, from January 2021 to October 2022.Results: The distribution of thyroid neoplasm patients is highest in late adulthood (36-45 years) with 15 patients (25.9%), followed by early elderly (46-55 years) with 15 patients (25.9%). The gender distribution shows more female patients, accounting for 43 (77.6%). The most common histopathological type is Colloid Goiter, with 20 patients (34.5%).Conclusion: The distribution of thyroid neoplasm patients is most prevalent between the ages of 35 to 55 years, predominantly in females, with the most common histopathological finding being Colloid Goiter. This study is expected to serve as a valuable source of information, enhancing public knowledge and awareness regarding thyroid neoplasm patients' characteristics.
The Use of Digital Illustrators in Histology Practicum Learning of Medical Students In Gorontalo: Perception Study Alian Ridho; Fatra Fasya Gusasi; Abdi Dzul Ikram Hasanuddin; Sri A Ibrahim
Jambura Medical and Health Science Journal Vol 1, No 2 (2022): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v1i2.16198

Abstract

Introduction: Medical students need to learn histology to understand the relation between microscopic structure and function of cells and tissues. Pictures of manual preparation made by students can be used as notes and can describe students' understanding of the observed structures. Producing good pictures in a short time is a challenge for medical students. The use of digital illustrator technology is expected to be a solution to overcoming these problems. This study aims to measure the perception of acceptance and satisfaction rate of medical students in Gorontalo towards digital illustrators in apprehend histology practicum.Method: Cross-sectional descriptive survey with modified questionnaires from previous studies. The sampling technique used purposive sampling and involved 54 first-year students. The raw data were analyzed using Microsoft Excel. The mean value calculated for each item was compared with the theoretical mean value of 2.50 to determine whether the respondents agreed with the statement.Results: All items have an average rating exceeding the theoretical mean of 2.50. Also, the mean of 3.91 (SD = 0.58) for all items substantially exceeds the theoretical mean. Items with the highest perceived rate of perceived utility, ease of use, intention to use, and actual use of digital illustrator teaching materials in learning practical skills will significantly increase students' motivation, interest, and acquisition of practical skills.Conclusion: the use of digital illustrators is perceived positively by medical students in helping histology practicum learning, which is indicated by the high rate of acceptance and rate of satisfaction with its use. 
Overview of Characteristics for Impaired Lung Function in Bentor Drivers in Gorontalo City in 2023 Muhammad Fahran Darise; Sri Manovita Pateda; Yancy Lumentut; Abdi Dzul Ikram Hasanuddin; Muhammad Zukri Antuke
Jambura Medical and Health Science Journal Vol 2, No 2 (2023): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v2i2.21824

Abstract

Introduction: Impaired lung function is a functional disorder of the lungs that causes a slowing of airflow during respiration. Bentor drivers are a profession with a risk of decreasing lung function due to work activities that are always on the road and exposed to motor vehicle pollution. Exposure to cigarette smoke in active and passive smokers is also significant in causing several other respiratory diseases, such as chronic obstructive pulmonary disease (COPD). The purpose of this study was to describe the risk factors for impaired lung function in Bentor drivers in Gorontalo City in 2023.Method: The research was conducted in June 2023 on eligible Bentor drivers accidentally found in Gorontalo City. The research instrument used a questionnaire, stress perception scale (SPS), and spirometry.Results: The results obtained are the distribution of risk factors for impaired lung function in Bentor drivers in Gorontalo City in 2023, based on length of work found more work more than five years (63.33%), more work more than 8 hours a day (75%), had smoking habits with a smoking duration of more than ten years (58.3%) and smoked more than ten cigarettes a day (62.5%) and had a severe perception of stress (66.6%).Conclusion: Bentor drivers are one of the contributing factors in impaired lung function. There is a relationship between the risk factors for smoking, length of work, duration of exposure to pollution, and perception of stress with lung function in Bentor drivers in Gorontalo City. Key words: Bentor drivers, lung function, smoking, stress perception
Peningkatan pengetahuan pencegahan stunting pada pasangan usia subur melalui penyuluhan kesehatan di Desa Bube Baru Kabupaten Bone Bolango Nasrun Pakaya; Ika Wulansari; Abdi Dzul Ikram Hasanuddin
BEMAS: Jurnal Bermasyarakat Vol 4 No 2 (2024): BEMAS: Jurnal Bermasyarakat
Publisher : LPPMPK-Sekolah Tinggi Teknologi Muhammadiyah Cileungsi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37373/bemas.v4i2.666

Abstract

Stunting masih menjadi masalah kesehatan yang prioritas untuk diselesaikan di negara kita. Meskipun tren stunting terus menurun, namun angkanya masih di atas standar world health organization (WHO) yang menargetkan di bawah 20%. Di Gorontalo, angka stunting masih jauh di atas pencapaian nasional yakni berkisar pada 29% pada tahun 2021. Beragam upaya perlu dilakukan dengan melibatkan kerjasama lintas sektor untuk berkontribusi pada penurunan angka stunting ini. Meningkatkan pengetahuan tentang pencegahan stunting pada masyarakat, khususnya pada pasangan usia subur merupakan salah satu strategi yang dipandang efektif. Hal ini dapat dicapai, diantaranya melalui penyuluhan kesehatan yang intens dan menarik. Berbekal dengan pengetahuan ini, diharapkan pasangan usia subur dapat menerapkannya secara langsung pada anak yang dilahirkan dan bisa berdampak pada menurunnya kejadian stunting. Kegiatan ini bertujuan untuk meningkatkan pengetahuan pasangan usia subur mengenai pencegahan stunting di Desa Bube Baru Kabupaten Bone Bolango. Kegiatan ini dilakukan dengan cara penyuluhan kepada 30 pasangan usia subur di wilayah tersebut. Penilaian tingkat pengetahuan pencegahan stunting dilakukan sebelum dan sesudah penyuluhan melalui kuesioner yang berisi pertanyaan tertutup. Uji Wilcoxon digunakan untuk menganalisis perubahan persepsi pengetahun yang terjadi. Hasil dari kegiatan ini menunjukkan terdapat peningkatan dari skor persepsi pengetahuan pasangan usia subur yang bermakna pada semua dimensi pertanyaan, baik definisi stunting, gejala stunting, penyebab stunting, faktor resiko stunting, dampak stunting, dan pencegahan stunting (semua p <0,05). Pada kesimpulannya, kegiatan penyuluhan pencegahan stunting pada pasangan usia subur di desa ini telah terlaksana dengan baik yang bisa diamati pada perbaikan persepsi pengetahuan yang dicapai
Characteristics of Lower Urinary Tract Symptoms (LUTS) in the Chronic Disease Management Program (Program Pengelolaan Penyakit Kronis, PROLANIS) Patients: A Pilot Study in Gorontalo Province Ibrahim, Sri A; Hasanuddin, Abdi Dzul Ikram
Jambura Medical and Health Science Journal Vol 3, No 2 (2024): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v3i2.27206

Abstract

Introduction: Lower Urinary Tract Symptoms (LUTS) are common in older adults and significantly impact individuals, caregivers, and the broader healthcare system. As the elderly population with various comorbidities increases, the burden of LUTS will increase. The chronic disease management program (Program Pengelolaan Penyakit Kronis, PROLANIS) is a government program generally followed by the elderly. This study aims to describe the characteristics of LUTS in PROLANIS patients in Gorontalo Province.Methods: The analytical observational study design, using a cross-sectional approach, was conducted on PROLANIS patients living in rural and urban areas in Gorontalo Province is between July - October 2023. An incidental sampling technique was conducted on eligible patients and areas. LUTS symptoms were measured using the International Prostate Symptom Score (IPSS) questionnaire and categorized into mild, moderate, and severe. LUTS symptoms were considered significant if the IPSS score was ≥8.Results: Of the 52 participants, 38.50% experienced significant LUTS symptoms. The majority of symptoms felt were nocturia (score two, as many as 23.10%) and mild symptoms (53.80%). Geographical differences, gender, education level, and age were not associated with LUTS symptoms (p 0.10).Conclusion: The prevalence of LUTS in patients undergoing PROLANIS is relatively high. The majority of LUTS patients have mild symptoms, with nocturia being the most common complaint compared to other symptoms. Further studies with a larger sample size and involving multiple sites are needed to obtain a more valid description of the characteristics of LUTS epidemiology in the PROLANIS population.                                                                         Keywords: Aged; Disease Management; Lower Urinary Tract Symptoms; Nocturia 
Comparison of Histology Practicum Exam Results Based on the Learning Style of Medical Students Sumargo, Kuni Zakiyyah; Hasanuddin, Abdi Dzul Ikram; Yusuf, Muhamad Nur Syukriani; Pateda, Andin Zahrani; Lestari, Putri Ayu Eka
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 13, No 2 (2024): June
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.90590

Abstract

Background: Histology is one of the essential subjects to be understood in medicine. Identifying the appropriate learning styles can be a solution to improve learning performance and achieve maximum learning outcomes.Aims: This study aims to determine the effectiveness of learning styles on histology practical exam results in medical students.Methods: This study used a cross-sectional design by involving students at the medical faculty of Universitas Negeri Gorontalo who contracted the biomedical course I in the 2022/2023 academic year. Learning styles are assessed using a visual-auditory-kinesthetic (VAK) questionnaire to categorize student learning styles. The results of the practicum exam in the form of numbers are obtained from the accumulated scores of the first practicum exam in histology with the topics of cytology, epithelium, and connective tissue. The one-way ANOVA test was conducted to analyze the data.Results: Out of 42 participants involved, visual, auditory, and kinesthetic learning styles were 18 people (42.9%), 23 people (54.8%), and 1 people (2.4%), respectively. Generally, the student practicum exam results were 63.62 ± 17.24. Based on the learning styles group of visual, auditory, and kinesthetic, the mean (SD) practicum exam results were 66.00 (14.60), 62.43 (19.29), and 48.00 (0.00), respectively (p-value = 0.541).Conclusion: Visual learning style shows marginally better practicum exam results than other learning styles. This result can be considered a learning strategy to improve the results of practicum exams, particularly in the subject of histology practicum courses.
Efek Simvastatin terhadap Urin dan Jaringan Buli-Buli pada Tikus Model Sistitis Interstisial Akut yang Diinduksi Protamin Sulfat Hasanuddin, Abdi Dzul Ikram; Minhajat, Rahmawati; Muis, Mirna
Alami Journal (Alauddin Islamic Medical) Journal Vol 7 No 2 (2023): JULY
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/alami.v7i2.39062

Abstract

The pathophysiology of interstitial cystitis (IC) is complicated and related to statin drug use without any established underlying mechanisms. This study used a rat model of acute IC caused by protamine sulfate to examine the effects of simvastatin on bladder and urine macro-tissue after simvastatin treatment. There were 12 adult female Wistar rats. Simvastatin 10 mg/kgBB + protamine sulfate group (S10P), Simvastatin 50 mg/kgBB + protamine sulfate group (S50P), and Placebo + Protamin Sulfate group (KP) were the three groups (each n=4) into which the subjects were grouped. Simvastatin or placebo CMC 0,5% was administered orally to all animals for 30 days, followed by an intravesical protamine sulfate (10 mg/ml) instillation procedure. All animals were gathered three days after intravesical therapy to collect urine samples and bladder tissue. Simvastatin group participants' levels of hematuria were significantly higher than those of the control group (p = 0.03). Only relative bladder weight was substantially higher in the S50P group than in the control group (p=0.032). Simvastatin group members did not substantially vary from the control group regarding bladder macroscopic oedema and haemorrhage. To conclude, simvastatin may influence the condition of tissue hypervascularization and hypertrophy, contributing to the chronicity of acute interstitial cystitis.
HUBUNGAN ANTARA GEJALA KLINIS DENGAN HASIL PEMERIKSAAN TES CEPAT MOLEKULER PADA PASIEN TUBERKULOSIS PARU Linda Wati; Nanang Roswita Paramata; Mohamad Zukri Antuke; Vivien Novarina A. Kasim; Abdi Dzul Ikram Hasanuddin
Medic Nutricia : Jurnal Ilmu Kesehatan Vol. 13 No. 2 (2025): Medic Nutricia : Jurnal Ilmu Kesehatan
Publisher : Cahaya Ilmu Bangsa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5455/nutricia.v13i2.11336

Abstract

Pendahuluan: Tuberkulosis adalah penyakit infeksi menular yang disebabkan oleh bakteri Mycobacterium tuberculosis. Penegakan diagnosis tuberkulosis dilakukan berdasarkan gejala klinis, pemeriksaan fisis, pemeriksaan bakteriologis, radiologis, dan pemeriksaan penunjang lainnya. Pemeriksaan penunjang salah satunya Tes Cepat Molekuler (TCM), yakni alat diagnosis utama tuberkulosis saat ini. Puskesmas Kota Selatan merupakan fasilitas layanan kesehatan primer rujukan di Kota Gorontalo dalam pemeriksaan Tes Cepat Molekuler untuk diagnosis penyakit tuberkulosis. Sehingga peneliti tertarik untuk meneliti hal ini dengan judul Hubungan antara Gejala Klinis dengan Hasil Pemeriksaan TCM pada Pasien TB Paru di Puskesmas Kota Selatan Tahun 2023. Metode: Penelitian ini menggunakan desain penelitian analitik dengan pendekatan cross-sectional. Sampel pada penelitian ini berjumlah 30 responden yang memenuhi kriteria inklusi dan eksklusi di Puskesmas Kota Selatan Tahun 2023. Analisis data dilaksanakan secara univariat dan bivariat dengan memakai uji Chi-Square. Hasil: Didapatkan gejala klinis respiratorius tertinggi yaitu respoden dengan satu gejala sebanyak 15 orang (50%). Gejala klinis sistemis yang dijumpai yaitu respoden tanpa gejala sebanyak 14 orang (46,7%). Tidak terdapat hubungan yang bermakna antara gejala klinis respiratorius dan sistemis dengan hasil pemeriksaan TCM pada responden tuberkulosis paru di Puskesmas Kota Selatan Tahun 2023 dengan p>0,05. Simpulan: Tidak terdapat hubungan yang bermakna antara gejala klinis respiratorius dan sistemis dengan hasil pemeriksaan TCM pada responden tuberkulosis paru. Diharapkan masyarakat dapat mencegah rantai penularan dengan deteksi dini ke fasilitas pelayanan kesehatan.
Inovasi Minuman Sehat Berbasis Jagung di Desa Kota Raja Boalemo Adam Mustapa, Mohamad; Taupik, Muhammad; Ikram Hasanuddin, Abdi Dzul
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 4, No 3 (2025)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v4i3.34145

Abstract

Jagung merupakan komoditas utama di Kabupaten Boalemo, khususnya di Desa Kota Raja, dengan potensi besar sebagai sumber pangan lokal. Namun pemanfaatannya masih terbatas pada konsumsi tradisional dan penjualan mentah, sehingga nilai tambahnya rendah. Kegiatan pengabdian ini bertujuan meningkatkan keterampilan masyarakat dalam mengolah jagung menjadi minuman sehat bernilai ekonomis. Metode pelaksanaan meliputi sosialisasi, pelatihan, dan praktik langsung pembuatan minuman jagung sehat. Hasil kegiatan menunjukkan partisipasi masyarakat yang tinggi dengan peningkatan pengetahuan gizi serta keterampilan teknis dalam pengolahan. Produk yang dihasilkan berupa teh rambut jagung dan susu jagung yang dinilai memiliki cita rasa khas, kaya gizi, dan berpotensi dikembangkan sebagai produk unggulan desa. Kegiatan ini berdampak positif dalam menumbuhkan kesadaran masyarakat akan pentingnya diversifikasi pangan serta membuka peluang usaha kecil berbasis komoditas lokal. Kesimpulannya, pemanfaatan jagung sebagai bahan dasar minuman sehat tidak hanya meningkatkan kesehatan dan ketahanan pangan, tetapi juga memperkuat ekonomi masyarakat desa. Saran kegiatan ke depan adalah perlunya pendampingan berkelanjutan terkait pengemasan, manajemen usaha, dan pemasaran produk.
Co-Authors Alian Ridho Fatra Fasya Gusasi Ibrahim, Sri A Ika Wulansari Isa, Abdul Hamid Lestari, Putri Ayu Eka Linda Wati Marshanda Tiara Posumah Mohamad Adam Mustapa Mohamad Zukri Antuke Muh Nur Syukriani Yusuf Muhammad Fahran Darise Muhammad Taupik Muhammad Zukri Antuke Muis, Mirna Nanang Roswita Paramata Nanang Roswita Paramata Nasrun Pakaya Nisa, Hasna Qurrotun Nur Hijra Puji Astuti Nurani Ibrahim Pateda, Andin Zahrani Rahmawati Minhajat, Rahmawati Ridho Tianggara Romy Abdul Sri A Ibrahim Sri Andriani Ibrahim Sri Manovita Pateda Sumargo, Kuni Zakiyyah Trinny Tuna Trinny Tuna Vivien Novarina A. Kasim Yancy Lumentut Zuhriana K. Yusuf