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Julinar Julinar
Universitas Abulyatama
Civil Engineering, Building, Construction & Architecture Law, Crime, Criminology & Criminal Justice Public Health Social Sciences Other

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Hubungan Kepatuhan Penggunaan Kelasi Besi Dengan Kadar Feritin Serum Pada Pasien Talasemia Anak Di RSUD Dr. Zainoel Abidin Nadia Salsabila; Julinar Julinar; Silvia Yasmin Lubis
KOLONI Vol. 5 No. 3 (2026): SEPTEMBER 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i3.1405

Abstract

Thalassemia is an inherited hemolytic disorder caused by impaired hemoglobin synthesis that requires lifelong regular blood transfusion therapy. Repeated blood transfusions can lead to iron accumulation, characterized by increased serum ferritin levels. Iron chelation therapy is required to reduce iron overload, with its effectiveness influenced by patient adherence. Objective: To analyze the relationship between adherence to iron chelation therapy and serum ferritin levels in pediatric patients with thalassemia at RSUD dr. Zainoel Abidin, Banda Aceh. Methods: This was an analytical observational study with a cross-sectional design using total sampling. The sample consisted of 137 patients who met the inclusion criteria. Adherence was measured using the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire, while serum ferritin levels were obtained from medical records. Data were analyzed using the Chi-Square test. Results: The majority of respondents were non-adherent to iron chelation therapy (64.2%) and had serum ferritin levels in the very high category (77.4%). All non-adherent respondents (88 patients) had serum ferritin levels in the very high category. The Chi-Square test demonstrated a statistically significant relationship between adherence to iron chelation therapy and serum ferritin levels (p = 0.000; p < 0.05). Conclusion: There was a statistically significant relationship between adherence to iron chelation therapy and serum ferritin levels in pediatric patients with thalassemia at RSUD dr. Zainoel Abidin, Banda Aceh.
Hubungan Jumlah Leukosit Dengan Durasi Demam Pada Anak Demam Tifoid Di Rumah Sakit Umum Pertamedika Ummi Rosnati Tahun 2025 Mulfira Ayu; Julinar Julinar; Khatab Khatab
KOLONI Vol. 5 No. 3 (2026): SEPTEMBER 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i3.1454

Abstract

Typhoid fever is an acute infection caused by Salmonella typhi bacteria that generally attacks children through contaminated food and drinks. The duration of fever in patients generally ranges from 7–14 days. In addition to clinical symptoms, accurate diagnosis requires laboratory examinations such as the number of leukocytes. In children, generally the number of normal leukocyte values is between 4,500-13,500 cells/mm³. The purpose of this study is to determine the relationship between the number of leukocytes and the duration of fever in cases of childhood typhoid fever at Pertamedika Ummi Rosnati Hospital in 2025. This type of study is quantitative descriptive with a cross-sectional design. The sampling technique in this study is total sampling. The sample in this study was 114 inpatients with a diagnosis of childhood typhoid fever. Data analysis used univariate and bivariate data. The results of the study showed that the incidence rate of typhoid fever in children at Pertamedika Ummi Rosnati Hospital in 2025 was 3%. The results of the univariate analysis showed that the most inpatient patients with the diagnosis of childhood typhoid fever were women, namely 57% with an age of > 5 years, which was 84%. The duration of fever had the most acute fever (< 7 days), which was 67% with the number of normal leukocytes (4500 cells/μL - 13500 cells/μL) which was 46%. The results of bivariate analysis using the chi-square statistical test obtained p-value of 0.000 (p < 0.05). The conclusion of this study is that there is a significant relationship between the number of leukocytes and the duration of fever in patients with childhood typhoid fever.
Co-Authors Khatab Khatab Mulfira Ayu Nadia Salsabila Silvia Yasmin Lubis