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All Journal Journal of Medicine and Health Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Christine Sugiarto, Christine
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Correlation of Total Lymphocyte Count with CD4 Count in HIV/AIDS Patients Sanjaya, Ardo; Sugiarto, Christine; Jonathan, Ronald
Journal of Medicine and Health Vol 1, No 1 (2015)
Publisher : Maranatha Christian University

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Abstract

HIV infection is a chronic infection of the immune system with a target of CD4 cells. Total lymphocyte count (TLC) can be done in resource-limited areas and are able to be used as a substitute to CD4 count. An increase in CD8 count can disturb the correlation between CD4 and TLC especially during the late clinical stage.Objective of this research is to find out the correlation of total lymphocyte count with CD4 count and to find out the influence of the clinical staging on the correlation of total lymphocyte count and CD4 count.This study is an observational, analytical and cross sectional study using the medical records of Klinik Teratai RSHS Bandung. The data is sorted according to the WHO clinical staging and are analyzed using Pearson’s correlation and Fisher’s transformation with α=0.05. The results showed that TLC have a correlation with CD4 count in all stadiums (r: 0,501-0,684, p<0,01). There is no significant difference of the correlation coefficients between the clinical stages (p>0.05). There is a correlation between TLC and CD4 count on HIV infected patients and there is no significant decrease of correlation of TLC and CD4 count on HIV infected patients with worsening of the WHO clinical stages. Keywords: CD4 count, total lymphocyte count, HIV/AIDS
Correlation of Total Lymphocyte Count with CD4 Count in HIV/AIDS Patients Sanjaya, Ardo; Sugiarto, Christine; Jonathan, Ronald
Journal of Medicine and Health Vol. 1 No. 1 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.334 KB) | DOI: 10.28932/jmh.v1i1.500

Abstract

HIV infection is a chronic infection of the immune system with a target of CD4 cells. Total lymphocyte count (TLC) can be done in resource-limited areas and are able to be used as a substitute to CD4 count. An increase in CD8 count can disturb the correlation between CD4 and TLC especially during the late clinical stage.Objective of this research is to find out the correlation of total lymphocyte count with CD4 count and to find out the influence of the clinical staging on the correlation of total lymphocyte count and CD4 count.This study is an observational, analytical and cross sectional study using the medical records of Klinik Teratai RSHS Bandung. The data is sorted according to the WHO clinical staging and are analyzed using Pearson’s correlation and Fisher’s transformation with α=0.05. The results showed that TLC have a correlation with CD4 count in all stadiums (r: 0,501-0,684, p<0,01). There is no significant difference of the correlation coefficients between the clinical stages (p>0.05). There is a correlation between TLC and CD4 count on HIV infected patients and there is no significant decrease of correlation of TLC and CD4 count on HIV infected patients with worsening of the WHO clinical stages. Keywords: CD4 count, total lymphocyte count, HIV/AIDS
VALIDATION OF HIV VIRAL LOAD Bioneer AccuPower® HIV-1 Quantitative RT-PCR Kit Compare to Roche-Cobas®4800 System HIV-1 Maskito, Veronika Juanita; Kosasih, Agus Susanto; Sugiarto, Christine
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2418

Abstract

The Bioneer AccuPower®HIV-1 Quantitative renewed the LoD from 38 IU/mL to 33 IU/mL. Performance evaluation of the kit has not been carried out in Indonesia since the alteration, as it is expected that the new kit will have improved sensitivity. This study is a cross-sectional evaluation of the correlation, sensitivity, and specificity of the Bioneer-AccuPower HIV Quantitative RT-PCR Kit compared to the Roche-Cobas 4800 System HIV-1. We obtained venous EDTA plasma from 211 HIV patients tested in the Clinical Pathology Laboratory of Dharmais Hospital, Indonesia. Subject werw  71 high-viral-load samples (>1000 copies/mL), 60 low-viral-load samples (<1000 copies/mL), and 80 undetectable-viral-load samples (<14.2 copies/mL/<24.42 IU/mL). Exclusion criteria were samples under the limit of quantification of each instrument (Roche-Cobas®4800 20 copies/mL (34.4 IU/mL); Bioneer-AccuPower 69.4 copies/mL (49.97 IU/mL)). Ethical Declaration released by Dharmais Hospital Ethical Committee No.DP.04.03/11.7/0872024. The categorical contingency correlation in determining whether the HIV viral load sample was high, low, or undetectable was 0.863. The sensitivity, specificity, and accuracy of the Bioneer-AccuPower HIV Quantitative RT-PCR Kit, compared to the Roche Cobas 4800 System HIV-1, in quantifying HIV viral load were 99.15%, 96.25%, and 98.10%, respectively. Regarding the limit of quantification of each instrument, the Bioneer-AccuPower HIV Quantitative RT-PCR Kit performed well in determining HIV RNA viral loads, making it suitable for HIV screening. It exhibits a strong correlation compared to the Roche Cobas® 4800 System HIV-1. However, it required a larger study that did not limit the sample according to the limit of quantification of both instruments and sequenced the discrepancy samples.
Co-Authors Agus Susanto Kosasih, Agus Susanto Ardo Sanjaya Maskito, Veronika Juanita Ronald Jonathan, Ronald