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All Journal Journal of Health Management and Pharmacy Exploration (JOHMPE)
Wulandari Wulandari
Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang, Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Antibacterial activity of active fraction of sweet corn hair extract (zea mays f saccharata kornicke & werner) against methicillin resistant staphylococcus aureus (MRSA) growth Juliani Khurfatul Jannah; Yuvianti Dwi Franyoto; Wulandari Wulandari; Jena Hayu Widyasti
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 1 (2023): February 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i1.130

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a Staphylococcus aureus bacterium that is resistant to methicillin-type antibiotics. This study aims to determine the antibacterial activity of the active fraction of sweet corn hair extract on the growth of Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria. Extraction was carried out by the remuneration method in 70% ethanol. In fractionation, liquid vacuum column chromatography with n-hexane, ethyl acetate, and methanol solvents was used. The fraction with the largest clear zone of methanol (100%) is with a clear zone diameter of 0.752 cm. Testing the antibacterial activity of ethanol extract at concentrations of 10%, 15%, and 20% obtained by clear zone with an average of 1,013; 1,073; 1,159 cm and in the active fraction with an average of 0,703; 0.903; 1,004 cm. Ciprofloxacin 0.005% was used as a positive control and DMSO as a negative control. The results showed that ethanol extract and an active fraction of sweet corn hair (Zea mays f saccharata Kornicke & Werner) had antibacterial activity against Methicillin-Resistant Staphylococcus aureus (MRSA). One-way ANAVA test results showed that there were significant differences in providing antibacterial activity (p> 0.05) between ethanol extract and active fractions at concentrations of 10%, 15%, and 20%. Flavonoid compounds, alkaloids, saponins, tannins, and triterpenoids in the active fraction of corn hair have antibacterial activity against MRSA bacteria.
W/O/W type lotion formulation of “arum manis” mango (Mangifera indica L.) pell as antioxidant Widya Rudiana; Wulandari Wulandari; Lilies Wahyu Ariyani
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 2 (2023): August 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i2.132

Abstract

Arum manis mango peel contains compounds, namely flavonoids. Flavonoid compounds act as natural antioxidants. The weakness of flavonoid compounds is that they are not stable to the influence of high temperature and light intensity, so that the arum manis mango peel extract is made in the form of lotion type W/O/W. This study aims to determine the physical characteristics and stability of the W/O/W type emulsion form optimum formula in double emulsion preparations and lotion preparations, determine the stability of W/O/W type lotion preparations during storage using the cycling test method and determine the IC50 value in the optimum formula. lotion preparation type W/O/W. The optimum formula for double emulsion type W/O/W is found in formula 5 with a ratio of primary emulsion: secondary emulsion (80%:20%) with span 80 (10%) and tween 20 (5%) concentrations while the optimum formula for lotion preparations found in formula 3 with a ratio of double emulsion type W/O/W: lotion base (80%:20%) with a concentration of stearic acid (5%), cetyl alcohol (2.5%) and glycerin (10%). In the antioxidant activity of lotion preparations, the IC50 value was 136.543 ppm and the stability test on the cycling test method had an unstable form.
Antioxidant activity test of ethanol extract of red algae (Kappaphycus alvarezii) green variety from north coasts of Jepara district with DPPH method Wulandari Wulandari; Arifah Irna Nur Widyastuti; Ahmad Fuad Masduqi
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 1 (2023): February 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i1.133

Abstract

Free radicals are unstable and highly reactive molecules that can cause cells damage. This cell damage can be inhibited by antioxidant compounds. One of the red algae, Kappaphycus alvarezii, is thought to contain phenolics and flavonoids compounds that can b used US antioxidants compounds. this study aims to determine the ethanol extract of red algae (Kappaphycus alvarezii) green variety has antioxidants activity using the DPPH method. this study also aims to determine the IC 50 value of the ethanolic extract of red algae (Kappaphycus alvarezii) green variety. The antioxidant activity test of red algae ethanol extract was carried out using the DPPH method. The results showed that the ethanolic extract of red algae (Kappaphycus alvarezii) green variety had antioxidant activity and the IC 50 value of the ethanolic extract of red algae was 242.28 ppm with a very weakcategory.
Antibacterial activity test of sweet arum mango peel extract gel preparation (Mangifera indica L.) against growth methicillin resistant staphylococcus aureus Wulandari Wulandari; Evira Refryliana
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 1 (2023): February 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i1.134

Abstract

Inappropriate use of antibiotics can make bacteria’s reistance that cause skin diseases, the example is acne. Acne tretment usually uses synthethic drugs that causes side effects, so the alternative are used by plants that come from nature. On of the plats that has the potential as an antibacterial is the arum manis mango (Mangifera indica L.) because contains compounds that can inhibit the growth of Mathicillin Resistant Staphylococcus aureus. The research of this study was to determine the antibacterial activity of extract  gel’s arum manis mango peel to c. Extract of arum manis mango peel was obtained remaserated using 70% ethanol solvent. The extract obtined were phytochemicel screening and affirmation tests using the TLC (Thin Layer Chromatography) method to ensure the compounds contained. Arum manis mango peel is preparation of gel with a concentration of 5%, 10%, 15%, 20%, 25%. The results showed that extract of arum manis mango peel preparation gel with concentrations of 5%, 10%, 15%, 20%, 25%. The results showed that extract of arum manis peel preparation gel with concentration 5%, 10%, 15%, 20%, 25% showed significant difference in potential of antibacterial.
Antibacterial activity of flavonoid isolated from jamblang leaves (Syzigium Cumini (L.) Skeels) against Staphylococcus aureus Sania Nabila; Wulandari Wulandari; Endang Dwi Wulansari
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 2 (2023): August 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i2.187

Abstract

Jamblang leaves (Syzigium cumini (L.) Skeels) is one type plants used as traditional medicine. Jamblang leaves contain several phytochemical compounds such as alkaloids, flavonoids, resins, tannins, and oils essential. Flavonoid compounds contained in jamblang leaves have as antibacterial ability. The identification of flavonoid compounds in jamblang leaves and the antibacterial activity of flavonoid compounds against Staphylococcus aureus have been carried out. This study was conducted from jamblang leaves (Syzigium cumini (L.) Skeels) at concentrations of 2%, 4% and 6% against the growth of Staphylococcus aureus bacteria and to determine the type and structure of flavonoid compounds that have antibacterial activity. The method used for the extraction is remaceration, the separation of compounds using preparative thin layer chromatography while the antibacterial activity test using the pitting method and identification of flavonoid compounds using UV-Vis spectrophotometry. Extraction of 500 g of jamblang leaf powder using 96% ethanol resulted in a yield of 22,08%. The results of the study tested the antibacterial activity of flavonoid compounds of jamblang leaves obtained an average of clear zones produced at concentrations of 2%, 4% and 6% consecutively amounting to 0.9540 cm; 1.0540 cm; 1.1583 cm and ciprofloxacin 0.005 % by 1.4077%. Based on statistical analysis of the SPSS program with anava test 1 way obtained the results of significant activity differences between concentrations. Identification of the structure in UV-Vis spectrophotometry shows that flavonoid compounds lead to 3,7,4' trihydroxy flavonol.
Co-Authors Ahmad Fuad Masduqi Arifah Irna Nur Widyastuti Endang Dwi Wulansari Evira Refryliana Juliani Khurfatul Jannah Lilies Wahyu Ariyani Sania Nabila Widya Rudiana Widyasti, Jena Hayu Yuvianti Dwi Franyoto