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All Journal Dentino: Jurnal Kedokteran Gigi Jurnal Penelitian Pendidikan IPA (JPPIPA)
Shieny Lokanata
Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Materials Science & Nanotechnology Physics

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Potential Effectiveness of Goji Berry (Lycium barbarum L.) Extract on Neutrophil Cell Count in Wistar Rats (Rattus norvegicus) Post Tooth Extraction Shieny Lokanata; Dian Soraya Tanjung; Tengku Annisa Sabila Putri
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.13937

Abstract

Tooth extraction causes tissue injury that triggers an inflammatory response, which is characterized by an increase in neutrophil counts. Although neutrophils play an essential role in the early phase of wound healing, prolonged inflammation may delay tissue regeneration. Goji berry (Lycium barbarum L.) contains various bioactive compounds that have potential anti-inflammatory effects. This study aimed to evaluate the effectiveness of goji berry extract on neutrophil counts in Wistar rats (Rattus norvegicus) following tooth extraction. This study was experimental laboratory research using a post-test group design. A total of 30 male Wistar rats were divided into five groups: negative control, positive control (povidone iodine), and three treatment groups receiving goji berry extract at concentrations of 15%, 30%, and 55%. The extract was formulated as a gel and applied topically to the extraction socket. Neutrophil counts were evaluated on days 1, 3, 5, and 7 through histopathological examination. Data were analyzed using the Shapiro–Wilk test, One Way ANOVA, and the LSD post hoc test. The results showed significant differences in neutrophil counts among groups on days 3, 5, and 7 (p<0.05). The 55% concentration demonstrated the most optimal reduction in neutrophil counts. It can be concluded that goji berry extract has potential as an alternative herbal therapy to support wound healing after tooth extraction.
A Study On The Effectiveness of Goji Berry Extract (Lycium Barbarum L.) In Increasing Collagen Fiber Density Following Tooth Extraction In Wistar Rats (Rattus Norvegicus) Shieny Lokanata; Dian Soraya Tanjung; Wulan Sahara Bengi; Mohammad Revaldy Sabran
Dentino: Jurnal Kedokteran Gigi Vol 11, No 2 (2026)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v11i2.25906

Abstract

Background: Tooth extraction initiates wound healing through inflammatory, proliferative, and remodelling phases, with collagen density serving as an important indicator of healing quality. Goji berry (Lycium barbarum L.) contains bioactive compounds, including polysaccharides, flavonoids, alkaloids, saponins, and tannins, which may promote fibroblast proliferation and collagen synthesis, supporting its potential to enhance post-extraction socket healing. Purpose: To evaluate the effectiveness of Goji berry extract gel at concentrations of 15%, 30%, and 55% on collagen fiber density in Wistar rat sockets subsequent to dental extraction. Methods: This research was an in vivo laboratory experimental study, single blind, utilizing a post-test only control group design. Thirty male Wistar rats were separated into five groups: negative control, positive control (Povidone Iodine), and Goji berry extract gel at concentrations of 15%, 30%, and 55%. Gel was applied topically twice daily for 14 days. Tissue samples were collected on days 3, 5, 7, and 14 for histopathological examination using an inverted phase contrast microscope at 400x magnification. Data were analyzed using One-Way ANOVA and Post-Hoc Duncan test. Results: Goji berry gel groups showed higher collagen density compared to both control groups across all observation days. Significant differences were found on days 5, 7, and 14 (p<0.05), with the 30% and 55% groups showing the highest collagen density values of 643.82 µm and 699.91 µm on day 14, respectively. Conclusion: Goji berry extract gel significantly increases collagen fiber density in Wistar rat sockets after tooth extraction, with 55% as the optimal concentration.
Co-Authors Dian Soraya Tanjung Mohammad Revaldy Sabran Tengku Annisa Sabila Putri Wulan Sahara Bengi