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All Journal Jurnal Surya Medika
Minto Rahaju
RSUD dr. Goeteng Taroenadibrata
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Literature Review: Hubungan Kadar D-Dimer dengan Tingkat Keparahan Pasien Covid-19: Literature Review: The Relationship of D-Dimer Levels with the Sverity of Covid-19 Ismi Andina Pertiwi; Tantri Analisawati Sudarsono; Dita Pratiwi Kusuma Wardani; Minto Rahaju
Jurnal Surya Medika (JSM) Vol. 9 No. 2 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i2.5726

Abstract

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) causes Corona Virus Disease-19 (COVID-19). D-dimer is one of the hemostasis tests performed on patients infected with the disease, it is a product of fibrin degradation and a biomarker of platelet disorders. With the development of COVID-19 as a pandemic, D-dimer has become an indicator for prognosis in COVID-19 patients. Based on symptoms, the severity of COVID-19 patients consists of mild, moderate, and severe symptoms. The author conducted a literature review regarding the correlation between D-dimer levels and the severity of COVID-19 patients. Data and theory were taken from ten references from several databases: Google Scholar, PubMed, Semantic Scholar, Science Direct, Garuda, and Neliti. The references taken were from the 2020-2022 range. In all of these references, statistical test results were obtained with a significant value below 0.05, so it can be concluded that there is a correlation between D-dimer levels and the severity of COVID-19. In COVID-19 infections with severe symptoms, immunothrombosis can occur due to hyperinflammatory conditions and cytokine storms. Immunothrombosis occurs as a result of the body's defense against viral infections. Damage to lung tissue in COVID-19 patients triggers a procoagulant response associated with inflammatory cytokines in blood vessel tissue.
Pengaruh Pemberian Obat Anti Tuberkulosisi (OAT) Terhadap Jumlah Trombosit pada Pasien TB Paru di BKPM Purwokerto: The Effect of Anti Tuberkulosis Drug (OAT) Towards the Number of Pulmonary TB Patients at BKPM Purwokerto Ika Wulan Nuri Anggreani; Tantri Analisawati Sudarsono; Dita Pratiwi Kusuma Wardani; Minto Rahaju
Jurnal Surya Medika (JSM) Vol. 9 No. 2 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i2.5727

Abstract

Pulmonary tuberculosis (TB) is an infection of the lungs characterized by pulmonary infiltrates and the formation of caseous granulomas, fibrosis, and cavities. It can be caused by the risk of transmission of the acid-fast bacillus Mycobacterium tuberculosis. One supportive treatment for pulmonary TB is the administration of anti-tuberculosis drugs (OAT). The content of rifampicin in the anti-tuberculosis drug can cause side effects of hemorrhagic disorders, namely thrombocytopenia. This study aims to determine the effect of giving OAT on platelet counts in TB patients in treatment phases of 0, 2, and 6 months at BKPM Purwokerto (Balai Kesehatan Paru Masyarakat). This was a type of analytic observational study with a cross-sectional design. Patients with pulmonary TB in treatment phase 0 were 15 at two months and 15 at six months in this study. Sampling was carried out by purposive sampling with inclusion and exclusion criteria. From this analysis, it is known that the data used the one-way ANOVA test. The results obtained have a p-value of 0.101 (p 0.05), so it can be concluded that there is no effect of the administration of OAT on platelet counts in TB patients in the treatment phases of 0, 2, and 6 months.
Co-Authors Dita Pratiwi Kusuma Wardani Ika Wulan Nuri Anggreani Ismi Andina Pertiwi Tantri Analisawati Sudarsono