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All Journal AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Life Science International Journal of Hydrological and Environmental for Sustainability
Madyawati Latief
Department of Chemistry, Faculty of Science and Technology, Universitas Jambi
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Environmental Science

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ANTI-INFLAMMATORY PREDICTION OF PERONEMIN COMPOUNDS FROM SUNGKAI (Peronema canescens Jack) AND THEIR DERIVATIVES Sofia Nurjannah; Dewi Arum; Indra Lasmana Tarigan; Madyawati Latief
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 9, No 2 (2023)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v9i2.11338

Abstract

Seven Sungkai Peronemins compounds belong to the alkaloid group, Peronemin A2, A3, B1, B2, B3, C1, and D1. Sungkai contains several bioactive compounds, triterpenoids, alkaloids, flavonoids, phenolics, steroids, and saponins which can act as anti-inflammatory candidates. Geometry optimization to find the most stable molecular structure and SMILES of the peronemin compound was used to predict pIC50 using the pChEMBL® program. From the test results of seven peronemin compounds, several candidate target molecules were obtained as potential anti-inflammatory agents, namely Angiotensin II type 2 (AT-2) receptors, Dihydrofolate reductase, and Phosphodiesterase 7A. Of the three target molecules, the Angiotensin II type 2 (AT-2) receptor on peronemin C1 has the highest pIC50 value of 6.79. The highest pIC50 value indicates an exponentially potent inhibitor in determining its biological activity. The anti-inflammatory function of AT-2 is revealed by its involvement in modulating mediators such as cytokines and chemokines.
Non-Ribosomal Inhibition of The Antibacterial Compound from Ethanol Extract of Gnetii gnemon Indra Lasmana Tarigan; Afidatul Muadifah; Madyawati Latief
Life Science Vol 12 No 2 (2023): November 2023
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/lifesci.v12i2.67183

Abstract

Melinjo (Gnetii gnemonii Folium) is a plant species originating from Peninsular Malaysia and Indonesia, known that contain several bioactive compounds that can be utilized as antibacterial agent. The aims of this study to analyze the profile of the melinjo leaf (Gnetii gnemonii Folium) bioactive compound which has an antimicrobial function by inhibiting the growth of S. aureus and activity in Ribosomal expression. The profile analysis of bioactive compound of melinjo leaf was carried out by screening phytochemical study, HPLC and analysis of antibacterial activity was carried out using turbidimetry method against Bacillus cereus (Bc), Escherichia coli (Ec), and Staphylococcus aureus (Sa). The ethanol extract of melinjo leaves contains tannins, saponins, alkaloids, flavonoids, triterpenoids, with the highest levels being flavonoids 67,117ppm. Analysis of bacterial growth using OD600 showed relatively lower antibacterial activity compared to control. The identification of RNA expression showed that the antibacterial compound of melinjo leaf extract did not have inhibition activity through the ribosome pathway it was thought to have an antibacterial mechanism through non-ribosomal inhibition of bacteria.
X-Ray Fluorescence Monitoring Metal Content and Nutrient Elements for Predicting Soil Fertility Parameters Based on pH in Ultisol Soil Samsidar Samsidar; Maison Maison; Ermadani Ermadani; Madyawati Latief; Jesi Pebralia; Hesti Riany; Dwi Rahma Amanda; Lucky Zaehir Maulana
International Journal of Hydrological and Environmental for Sustainability Vol. 2 No. 3 (2023): International Journal of Hydrological and Environmental for Sustainability
Publisher : CV FOUNDAE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58524/ijhes.v2i3.290

Abstract

Soil fertility parameters, including macronutrients, micronutrients, and metal content, are very important for optimizing agricultural and plantation land management. Ultisol is a type of soil that is commonly used as a planting medium for oil palm plantations, rubber, and various types of vegetables. Continuous land use causes variations in nutrient and metal content. This change is also caused by the fertilization process and the characteristics of the plants grown in the area. In this study, an analysis of soil fertility parameters (macronutrients, micronutrients, and metal content) was analyzed using X-Ray Fluorescence (XRF) on Ultisol soil taken from Muara Jambi Regency, Indonesia. This analysis was conducted across land-use areas (Palm, Rubber, Vegetables, and Forest). Subsequently, the obtained measurements were used to model correlations with soil pH values to predict soil fertility parameters. The quantitative results showed that the metal content values were reasonably consistent across all locations regarding metal types and their percentage concentrations. However, locations 1 (T1) and 2 (T2) have higher aluminum (Al) content than locations 3 and 4 and lower magnesium (Mg) content. The modeling, when correlated with pH values, indicated that metal elements correlated 0.938, macronutrients 0.934, and micronutrients 0.767. From these correlations, it can be qualitatively inferred that there is a strong relationship between pH and the presence of metal content, macronutrients, and micronutrients. In the future, this can serve as a model for estimating the presence of soil fertility parameters.
Co-Authors Afidatul Muadifah Dewi Arum Dwi Rahma Amanda Ermadani Ermadani Hesti Riany Indra Lasmana Tarigan Jesi Pebralia Lucky Zaehir Maulana Maison Maison Samsidar Samsidar Sofia Nurjannah