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All Journal AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Life Science
Madyawati Latief
Department of Chemistry, Faculty of Science and Technology, Universitas Jambi
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Energy

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ANTI-INFLAMMATORY PREDICTION OF PERONEMIN COMPOUNDS FROM SUNGKAI (Peronema canescens Jack) AND THEIR DERIVATIVES Sofia Nurjannah; Dewi Arum; Indra Lasmana Tarigan; Madyawati Latief
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 9, No 2 (2023)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v9i2.11338

Abstract

Seven Sungkai Peronemins compounds belong to the alkaloid group, Peronemin A2, A3, B1, B2, B3, C1, and D1. Sungkai contains several bioactive compounds, triterpenoids, alkaloids, flavonoids, phenolics, steroids, and saponins which can act as anti-inflammatory candidates. Geometry optimization to find the most stable molecular structure and SMILES of the peronemin compound was used to predict pIC50 using the pChEMBL® program. From the test results of seven peronemin compounds, several candidate target molecules were obtained as potential anti-inflammatory agents, namely Angiotensin II type 2 (AT-2) receptors, Dihydrofolate reductase, and Phosphodiesterase 7A. Of the three target molecules, the Angiotensin II type 2 (AT-2) receptor on peronemin C1 has the highest pIC50 value of 6.79. The highest pIC50 value indicates an exponentially potent inhibitor in determining its biological activity. The anti-inflammatory function of AT-2 is revealed by its involvement in modulating mediators such as cytokines and chemokines.
Non-Ribosomal Inhibition of The Antibacterial Compound from Ethanol Extract of Gnetii gnemon Indra Lasmana Tarigan; Afidatul Muadifah; Madyawati Latief
Life Science Vol 12 No 2 (2023): November 2023
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/lifesci.v12i2.67183

Abstract

Melinjo (Gnetii gnemonii Folium) is a plant species originating from Peninsular Malaysia and Indonesia, known that contain several bioactive compounds that can be utilized as antibacterial agent. The aims of this study to analyze the profile of the melinjo leaf (Gnetii gnemonii Folium) bioactive compound which has an antimicrobial function by inhibiting the growth of S. aureus and activity in Ribosomal expression. The profile analysis of bioactive compound of melinjo leaf was carried out by screening phytochemical study, HPLC and analysis of antibacterial activity was carried out using turbidimetry method against Bacillus cereus (Bc), Escherichia coli (Ec), and Staphylococcus aureus (Sa). The ethanol extract of melinjo leaves contains tannins, saponins, alkaloids, flavonoids, triterpenoids, with the highest levels being flavonoids 67,117ppm. Analysis of bacterial growth using OD600 showed relatively lower antibacterial activity compared to control. The identification of RNA expression showed that the antibacterial compound of melinjo leaf extract did not have inhibition activity through the ribosome pathway it was thought to have an antibacterial mechanism through non-ribosomal inhibition of bacteria.
Co-Authors Afidatul Muadifah Dewi Arum Indra Lasmana Tarigan Sofia Nurjannah