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Monika Chauhan, Monika
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Medicine & Pharmacology

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Curcumin: a review Chauhan, Monika; Saha, Suman; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

The main objective of this review article is to overcome or to improve the problems related with curcumin with the help of new technologies or modifications to make a promising therapeutic agent which gives a good therapeutic response. Curcumin, a known natural polyphenolic compound obtained from dietary spice turmeric, possesses pharmacologic effects including anti-inflammatory, antioxidant, and many other activities. Clinical trials   on curcumin have shown its safety and efficacy even at high doses in humans. But inspite of that it shows poor bioavailability (oral bioavailability) which is one of the major problems regarding curcumin. There are other reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numbers of approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipids complex; and fifth, the use of structural analogues of curcumin. 
Comparative study of hexane extract for volatile and non volatile components of leaves and rhizomes of acorus calamus linn. using high performance thin layer chromatography (HPTLC) Bisht, A S; Chauhan, Monika; Joshi, A; Joshi, Y; Singh, V; Juyal, D
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

The present communication attempts to evaluate the comparative study of leaves and rhizomes of Acorus calamus Linn. (Family; Araceae) using High Performance Thin Layer Chromatography (HPTLC). Since the plant contains various volatile and non-volatile components so paper advocates the quantitative study using hexane extract. Acorus calamus Linn. is a well known medicinal plant in traditional medical systems  having various ethno-pharmacological uses. As the official source of the plant is roots and rhizomes, but here study had been done comparatively with leaves. Previously leaves of Acorus calamus were not regarded as useful part of plant, but recently there is growing interest in leaves of the said plant. The leaves are considered to possess various activities such as an insect repellent, when cut up and kept with grain storage; anti-hyperlipidemic; anti-diabetic; antipsychotic; anti-inflammatory and analgesic. As there is no detailed work reported in leaf constituents of the plant, therefore the study revealed specific quantitative HPTLC data for the plant for future standardization work. HPTLC analysis of both leaves and rhizomes showed the presence of Asarone, ?- sitosterol, lupeol and Ursolic acid when matched with marker compounds. 
Curcumin: a review Chauhan, Monika; Saha, Suman; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.24 KB)

Abstract

The main objective of this review article is to overcome or to improve the problems related with curcumin with the help of new technologies or modifications to make a promising therapeutic agent which gives a good therapeutic response. Curcumin, a known natural polyphenolic compound obtained from dietary spice turmeric, possesses pharmacologic effects including anti-inflammatory, antioxidant, and many other activities. Clinical trials on curcumin have shown its safety and efficacy even at high doses in humans. But inspite of that it shows poor bioavailability (oral bioavailability) which is one of the major problems regarding curcumin. There are other reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numbers of approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipids complex; and fifth, the use of structural analogues of curcumin.
Comparative study of hexane extract for volatile and non volatile components of leaves and rhizomes of Acorus calamus linn. using high performance thin layer chromatography (HPTLC) Bisht, AS; Chauhan, Monika; Joshi, A; Joshi, Y; Dimri, A; Singh, V; Juyal, D
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (616.714 KB)

Abstract

The present communication attempts to evaluate the comparative study of leaves and rhizomes of Acorus calamus Linn. (Family; Araceae) using High Performance Thin Layer Chromatography (HPTLC). Since the plant contains various volatile and non-volatile components so paper advocates the quantitative study using hexane extract. Acorus calamus Linn. is a well known medicinal plant in traditional medical systems having various ethno-pharmacological uses. As the official source of the plant is roots and rhizomes, but here study had been done comparatively with leaves. Previously leaves of Acorus calamus were not regarded as useful part of plant, but recently there is growing interest in leaves of the said plant. The leaves are considered to possess various activities such as an insect repellent, when cut up and kept with grain storage; anti-hyperlipidemic; anti-diabetic; antipsychotic; anti-inflammatory and analgesic. As there is no detailed work reported in leaf constituents of the plant, therefore the study revealed specific quantitative HPTLC data for the plant for future standardization work. HPTLC analysis of both leaves and rhizomes showed the presence of Asarone, β- sitosterol, lupeol and Ursolic acid when matched with marker compounds.
Co-Authors A Joshi, A A S Bisht, A S Amit Roy, Amit Bisht, AS D Juyal, D Dimri, A Suman Saha, Suman V Singh, V Y Joshi, Y