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Amit Roy, Amit
Rajshahi University of Engineering & Technology
Chemistry Energy Medicine & Pharmacology

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Curcumin: a review Chauhan, Monika; Saha, Suman; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

The main objective of this review article is to overcome or to improve the problems related with curcumin with the help of new technologies or modifications to make a promising therapeutic agent which gives a good therapeutic response. Curcumin, a known natural polyphenolic compound obtained from dietary spice turmeric, possesses pharmacologic effects including anti-inflammatory, antioxidant, and many other activities. Clinical trials   on curcumin have shown its safety and efficacy even at high doses in humans. But inspite of that it shows poor bioavailability (oral bioavailability) which is one of the major problems regarding curcumin. There are other reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numbers of approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipids complex; and fifth, the use of structural analogues of curcumin. 
Phytosome: a novel dosage form for herbal drug delivery Choudhury, Ananta; Verma, Swati; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
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Phytosome is a complex of a natural active ingredient and phospholipids. The term ‘Phyto’ means plant while ‘some’ means cell like structure. It is claimed that phytosome increases absorption of "conventional herbal extracts" or isolated active principles both orally as well as topically. In this era phytosome gain popularity as a potential drug delivery device due to excessive demand and utility of herbs or herb based medicines. This advance technology offers amenities like improved absorption, enhanced delivery & increased bioavailability of herbal extracts. These drug-phospholipid complexes can be fabricated in the form of solution, suspension, emulsion, syrup, lotion, gel, cream, aqueous micro dispersions. Standardized plant extracts, mainly polar phytoconstituents like flavonoids, terpenoids, tannins, xanthones shall be introduced in form of phytosome.
Liposome: method of preparation, advantages, evaluation and its application Pradhan, Bhupendra; Kumar, Narendra; Saha, Suman; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 3 No 3 (2015)
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Notable research in drug delivery started in 1950’s with the advent of polyclonal antitumor antibodies developed for targeting. Bangham et. Al. discovered liposomes in early 1960’s. In this review article we are discussing about the liposome, methods of the liposome preparation advantages and their different application of the liposome. Liposomes are artificially prepared vesicles made of lipid bilayer. Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases. Liposome is used for the targeted drug delivery system and increase the bioavailability and half life of the any drugs. Liposomes are surfactants, sphingolipids, glycol-lipids, long chain fatty acids and even membrane proteins and drug molecules or it is also called vesicular system. Liposomes have been extensively investigated for drug delivery, drug targeting, controlled release and increased solubility
Recent status on carbohydrate metabolizing enzyme inhibitors in regulation of diabetes: a mechanism based review Sinha, Durgeshnandani; Satapathy, Trilochan; Dewangan, Mehendra Kumar; Kumar, Arvind; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 3 No 2 (2015)
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The important therapeutic approach for treating type 2 diabetes mellitus is to decrease the post-prandial glucose levels which could be done by decreasing the absorption of glucose through the inhibition of the carbohydrates-hydrolyzing enzymes such as α-amylase and α-glucosidase present in the small intestinal brush border that are responsible for the breakdown of oligosaccharides and disaccharides into monosaccharide’s and suitable for absorption. Inhibition of α-amylase generally considered as strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity. Among the marketed allopathic preparations carbohydrates-hydrolyzing enzymes Inhibitors like acarbose, voglibose etc delay carbohydrate digestion and prolong overall carbohydrate digestion time, causing a reduction in the rate of glucose absorption and consequently blunting the postprandial plasma glucose rise. Some of the plants are also considered as an important source of chemical constituent with potential for inhibition of α-amylase and can be used as therapeutic purposes. In this review our efforts have been devoted to explore the mechanism based carbohydrates-hydrolyzing enzymes Inhibitors for the regulation of diabetes.
Clock gene variation in type 2 diabetes: a review Praveen, Nushrat; Satapathy, Trilochan; Prasad, Pushpa; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 3 No 1 (2015)
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Abstract

Diabetes mellitus type 2 is a long-standing metabolic disorder that is exemplify by high blood sugar, insulin resistance, and comparative lack of insulin. General symptoms include increased thirst, frequent urination, and unsolved weight loss. Type 2 diabetes is mainly due to obesity and not sufficient work out in public who are heritably prone.Circadian clocks are significant to keep the moment in the sequence of physiological practice, series of behaviour and metabolism. The plasma level of glucose and numerous hormones implicated in glucose homeostasis for example insulin and glucagon exhibit circadian variation. Circadian desynchrony, a feature of alter occupation elevated-fat diet feed and sleep distraction in individual have been linked with metabolic disorders for instance obesity and type 2 diabetes. Circadian rhythm distraction can cause different fitness disarray. Current reading has discovered a seal connection among the pathophysiology of metabolic condition, which is characterized by obesity and hyperglycemia, and the operation of interior molecular clocks.
Development and characterization of topical phyto-formulation for antifungal activity Choudhury, Ananta; Verma, Reema; Sinha, Devnarayan; Sahu, Saurabh; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
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Abstract

The present study was aimed to develop a potent antifungal topical gel using Curcumin and fluconazole in suitable combination. In these studies we have prepared different gel formulations using polymer like carbapol, Hydroxy propylmethyl cellulose, as well as excepients like tri-ethanolamine, methanol, glycerin and purified water. The formulated gel were evaluated in context of different parameters like drug content, pH, spreadability viscosity , in-vitro drug release , anti-microbial effect etc. Candida albicans was used as a model fungus to evaluate the antifungal activity of the prepared formulations.
Review on natural gums and mucilage and their application as excipient Bahadur, Sanjib; Sahu, Uttam; Sahu, Dipesh; Sahu, Ghanshyam; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 5 No 4 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/2348-0335.2017.0010

Abstract

Natural mucilage’s are included in novel drug delivered (NDDS) to multitask functions and in any cases directly or indirectly control the increase and rate of drug release. Substantial research efforts have been directed towards develop safe and efficient natural based mucilage particulate drug delivery systems., natural gums and mucilages and their isolation, purification, standardization and characterization characteristics along with their applications are covered. Recent trend towards the use of plant based and natural products demands the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural mucilages have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, and widely available.
Formulation and evaluation of enteric coated microcapsules of diclofenac sodium for modified release by combination of wet granulation and thermal change method Roy, Amit; Saha, Suman; Choudhury, Ananta; Bahadur, Sanjib; Baghel, Pragya; Chanda, Ranabir
Journal of Applied Pharmaceutical Research Vol 2 No 4 (2014)
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Abstract

The purpose of the present work was to develop optimized novel enteric microcapsules containing diclofenac sodium, a non steroidal anti inflammatory drug (NSAID) used for rheumatoid arthritis, for improved delivery and to diminish its adverse effect after oral administration. The microcapsule was prepared by using different polymers and the enteric coating was provided by using an innovative technique combining wet granulation method and thermal change method. This work also investigated different levels of enteric polymers like cellulose acetate phthalate (CAP) (X1) and ethyl cellulose (EC) (X2) and the stirring speed during coating ethyl cellulose (X3), by using 23 full factorial design. The dependent variables assessed were % yield (Y1), Q8 (% drug released after 8 hour) (Y2), n (Diffusion coefficient) (Y3), DEE (Drug entrapment efficiency) (Y4). The main effect and interaction terms were quantitatively evaluated using a mathematical model. The prepared microcapsules were evaluated for percentage drug dissolved, scanning electron microscopy, drug excipient interaction, angle of repose, particle size. Mean dissolution time (MDT) was used to compare dissolution patterns obtained. The results showed that X1 and X2 significantly affected the release properties. 
Standardization of herbal medicines – an overview Bhairam, Monika; Roy, Amit; Bahadur, Sanjib; Banafar, Alisha; Turkane, Dhanushram
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
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Abstract

In the few decades, there has been exponentional growth in the field of herbal medicines. Most of the traditional systems of medicine are effective due to lack of standardization. So there is a need to develop a standardization technique. Standardization of herbal formulation is essential in order to assess the quality, purity, safety and efficacy of the drug. There is increasing awareness and general acceptability of the use herbal drugs in today’s medical practice. The world population depends on herbal medicines and product for healthy living. This rise in the use of herbal product has also given rise to various forms of adulteration of the products, which leading to consumers’ and manufacturers’ disappointment and in some instances fatal consequences. The challenge is innumerable and enormous, to fulfill the need of global herbal market. The standardization of this formulations like the organoleptic characters, physical properties, the various physic-chemical properties such as moisture content, ash values, extractive values need to be carried out along with Thin layer chromatography and heavy metal content study should also carried out to ascertain the quality, purity and safety of this herbal formulation.
Antihyperlipidemic potential of herbals Yadav, Swati; Satapathy, Tilochan; Roy, Amit; Prasad, Pushpa
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
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Abstract

One of the most widespread diseases in the world is Coronary Heart Disease (CHD). It is also one of the most preventable. This review explores the management of CHD through changes in dietary modifications, lifestyle, and the use of dietary supplements and botanicals.
Co-Authors Aditi Dubey, Aditi Alisha Banafar, Alisha Ananta Choudhury, Ananta Arvind Kumar, Arvind B. K. Das, B. K. Bhupendra Pradhan, Bhupendra Chandrakar, Shashikant Devnarayan Sinha, Devnarayan Dhanushram Turkane, Dhanushram Dipesh Sahu, Dipesh Durgeshnandani Sinha, Durgeshnandani Ghanshyam Sahu, Ghanshyam Gupta, Pushpa Prasad Kumar Dewangan, Mehendra Mehendra Kumar Dewangan, Mehendra Kumar Mohd. Rafiqul Alam Beg, Mohd. Rafiqul Alam Monika Bhairam, Monika Monika Chauhan, Monika Najmul Hoque, Najmul Narendra Kumar Nushrat Praveen, Nushrat Parveen, Nushrat Pragya Baghel, Pragya Pushpa Prasad, Pushpa Ranabir Chanda, Ranabir Reema Verma, Reema Sahu, Uttam Kumar Sanjib Bahadur, Sanjib Saurabh Sahu, Saurabh Suman Saha, Suman SWATI VERMA Swati Yadav, Swati Tilochan Satapathy, Tilochan Trilochan Satapathy, Trilochan Uttam Sahu, Uttam Verma, Renuka