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All Journal Journal of Applied Pharmaceutical Research Journal of Renewable Energy, Electrical, and Computer Engineering
Shailendra Kumar Jha, Shailendra Kumar
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Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Energy Engineering Medicine & Pharmacology

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Simultaneous estimation of pyrantel pamoate, praziquantel & febantel by high performance liquid chromatography using dual wavelength Sajjanwar, Rupali; Bhaskaran, Shyamala; Kakati, Kulesh; Jha, Shailendra Kumar
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

A sensitive, fast, and stability-indicating gradient reverse-phase liquid chromatography method was developed for quantitative simultaneous estimation of Pyrantel pamoate, Praziquantel and Febantel using reverse phase high performance liquid chromatography by  gradient elusion with dual wavelength at  a specified time interval. All three ingredients were well separated with Phenominax Hypersil C18 (ODS) (4.6 X100mm) 3µm column. The various factors affecting different parameters during method development by HPLC was analyzed and standardized.
A validated reverse phase HPLC method for the simultaneous estimation of clopidogrel bisulfate and rivaroxaban in pharmaceutical application Sajjanwar, Rupali; Bhaskaran, Shyamala; Kakati, Kulesh; Jha, Shailendra Kumar
Journal of Applied Pharmaceutical Research Vol 3 No 3 (2015)
Publisher : Creative Pharma Assent

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Abstract

A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Clopidogrel bisulfate and rivaroxaban in pharmaceutical dosage forms. The combination drug was analyzed on BDS hypersil C18, 250mm × 4.6mm, 5µ, Thermo scientific. Mobile phase consisted of  buffer (0.05M KH2PO4 pH 4.0) : methanol in the ratio of 30:70 v/v delivered at a flow rate of 1.0 ml / min and wavelength of detection at 220 nm. The retention times of Clopidogrel bisulfate and Rivaroxaban were 2.39 min and 4.04 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for the determination of these drugs in combined dosage forms.
Development of stability indicating, validated single dissolution method for simultaneous estimation of clopidogrel bisulfate and rivaroxaban in tablet dosage formulation by RP-HPLC method Sajjanwar, Rupali; Bhaskaran, Shyamala; Kakati, Kulesh; Jha, Shailendra Kumar
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (204.931 KB)

Abstract

A dissolution method was developed for combination of two drugs which are already marketed as an individual product, Clopidogrel Bisulfate Tablets USP 75 mg and another is Rivaroxaban Tablets 10 mg & 20 mg. It was emphasized that both products have several advantages when given as combination therapy. Hence, the preference was given to develop a single dissolution method for the analysis of both the active components. This article presents a single dissolution method to accommodate both drugs. The method uses USP Type II Apparatus (paddles) at 75 rpm in 1000 mL of Acetate buffer (pH 4.5) medium containing 1% Sodium Lauryl Sulfate as surfactant at 37 °C± 0.5°C . This dissolution methodology provides good dissolution profiles for both Clopidogrel Bisulfate and Rivaroxaban and is able to discriminate the changes in composition, manufacturing process and stability for the combination tablets. To quantitate both drugs simultaneously, a rapid isocratic reversed-phase liquid chromatographic method was developed and validated.
A validated reverse phase hplc method for the simultaneous estimation of clopidogrel bisulfate and rivaroxaban in pharmaceutical application Sajjanwar, Rupali; Bhaskaran, Shyamala; Kakati, Kulesh; Jha, Shailendra Kumar
Journal of Applied Pharmaceutical Research Vol. 3 No. 3 (2015)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.402 KB)

Abstract

A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Clopidogrel bisulfate and rivaroxaban in pharmaceutical dosage forms. The combination drug was analyzed on BDS hypersil C18, 250mm × 4.6mm, 5µ, Thermo scientific. Mobile phase consisted of buffer (0.05M KH2PO4 pH 4.0) : methanol in the ratio of 30:70 v/v delivered at a flow rate of 1.0 ml / min and wavelength of detection at 220 nm. The retention times of Clopidogrel bisulfate and Rivaroxaban were 2.39 min and 4.04 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for the determination of these drugs in combined dosage forms.
Voltage Profile Improvement of Distribution System via Integration of Distributed Generation Resources Pokhrel, Biswas Babu; Shrestha, Ashish; Phuyal, Sudip; Jha, Shailendra Kumar
Journal of Renewable Energy, Electrical, and Computer Engineering Vol 1, No 1 (2021): March 2021
Publisher : Institute for Research and Community Service, Universitas Malikussaleh, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jreece.v1i1.3519

Abstract

This study attempts to identify the causes and possible solutions for voltage profile issues in the lower land of Nepal, and is specifically focused on Laukahi feeder, a radial distribution system with an approximate length of 65 km and distributed at 11KV system voltage. Currently, the end-users feeding through this feeder are getting extremely poor voltage along with frequent interruptions in the power supply. In this study, a forward/ backward sweep algorithm is used to analyze the load flow of the distribution system, whereas ant colony optimization (ACO) technique is used to identify the best location for the Distributed Generator (DG) penetrations. After completion of this study, it is found that, the branch loss of the feeder can be reduced up to 87.22%, and voltage profile can be improved from 0.828 pu to 0.982 pu by integrating some form of DGs.
Voltage Profile Improvement of Distribution System via Integration of Distributed Generation Resources Pokhrel, Biswas Babu; Shrestha, Ashish; Phuyal, Sudip; Jha, Shailendra Kumar
Journal of Renewable Energy, Electrical, and Computer Engineering Vol. 1 No. 1 (2021): March 2021
Publisher : Institute for Research and Community Service (LPPM), Universitas Malikussaleh, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jreece.v1i1.3519

Abstract

This study attempts to identify the causes and possible solutions for voltage profile issues in the lower land of Nepal, and is specifically focused on Laukahi feeder, a radial distribution system with an approximate length of 65 km and distributed at 11KV system voltage. Currently, the end-users feeding through this feeder are getting extremely poor voltage along with frequent interruptions in the power supply. In this study, a forward/ backward sweep algorithm is used to analyze the load flow of the distribution system, whereas ant colony optimization (ACO) technique is used to identify the best location for the Distributed Generator (DG) penetrations. After completion of this study, it is found that, the branch loss of the feeder can be reduced up to 87.22%, and voltage profile can be improved from 0.828 pu to 0.982 pu by integrating some form of DGs.
Co-Authors Kulesh Kakati, Kulesh Phuyal, Sudip Pokhrel, Biswas Babu Rupali Sajjanwar, Rupali Shrestha, Ashish Shyamala Bhaskaran, Shyamala