Journal of Applied Pharmaceutical Research
Vol 3 No 3 (2015)

A validated reverse phase HPLC method for the simultaneous estimation of clopidogrel bisulfate and rivaroxaban in pharmaceutical application

Sajjanwar, Rupali (Unknown)
Bhaskaran, Shyamala (Unknown)
Kakati, Kulesh (Unknown)
Jha, Shailendra Kumar (Unknown)

Article Info

Publish Date
30 Nov 2015

Abstract

A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Clopidogrel bisulfate and rivaroxaban in pharmaceutical dosage forms. The combination drug was analyzed on BDS hypersil C18, 250mm × 4.6mm, 5µ, Thermo scientific. Mobile phase consisted of  buffer (0.05M KH2PO4 pH 4.0) : methanol in the ratio of 30:70 v/v delivered at a flow rate of 1.0 ml / min and wavelength of detection at 220 nm. The retention times of Clopidogrel bisulfate and Rivaroxaban were 2.39 min and 4.04 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for the determination of these drugs in combined dosage forms.

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Journal Info
Journal of Applied Pharmaceutical Research
Website

Abbrev

joapr

Publisher

Creative Pharma Assent

Subject

Medicine & Pharmacology

Description

Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, ...