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All Journal Journal of Applied Pharmaceutical Research Computer Science and Information Technologies
Arvind Kumar, Arvind
Motilal Nehru National Institute of Technology Allahaba
Computer Science & IT Engineering Medicine & Pharmacology

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Recent status on carbohydrate metabolizing enzyme inhibitors in regulation of diabetes: a mechanism based review Sinha, Durgeshnandani; Satapathy, Trilochan; Dewangan, Mehendra Kumar; Kumar, Arvind; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 3 No 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

The important therapeutic approach for treating type 2 diabetes mellitus is to decrease the post-prandial glucose levels which could be done by decreasing the absorption of glucose through the inhibition of the carbohydrates-hydrolyzing enzymes such as α-amylase and α-glucosidase present in the small intestinal brush border that are responsible for the breakdown of oligosaccharides and disaccharides into monosaccharide’s and suitable for absorption. Inhibition of α-amylase generally considered as strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity. Among the marketed allopathic preparations carbohydrates-hydrolyzing enzymes Inhibitors like acarbose, voglibose etc delay carbohydrate digestion and prolong overall carbohydrate digestion time, causing a reduction in the rate of glucose absorption and consequently blunting the postprandial plasma glucose rise. Some of the plants are also considered as an important source of chemical constituent with potential for inhibition of α-amylase and can be used as therapeutic purposes. In this review our efforts have been devoted to explore the mechanism based carbohydrates-hydrolyzing enzymes Inhibitors for the regulation of diabetes.
Recent status on carbohydrate metabolizing enzyme inhibitors in regulation of diabetes: a mechanism based review Sinha, Durgeshnandani; Satapathy, Trilochan; Kumar Dewangan, Mehendra; Kumar, Arvind; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (938.073 KB)

Abstract

The important therapeutic approach for treating type 2 diabetes mellitus is to decrease the post-prandial glucose levels which could be done by decreasing the absorption of glucose through the inhibition of the carbohydrates-hydrolyzing enzymes such as α-amylase and α-glucosidase present in the small intestinal brush border that are responsible for the breakdown of oligosaccharides and disaccharides into monosaccharide’s and suitable for absorption. Inhibition of α-amylase generally considered as strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity. Among the marketed allopathic preparations carbohydrates-hydrolyzing enzymes Inhibitors like acarbose, voglibose etc delay carbohydrate digestion and prolong overall carbohydrate digestion time, causing a reduction in the rate of glucose absorption and consequently blunting the postprandial plasma glucose rise. Some of the plants are also considered as an important source of chemical constituent with potential for inhibition of α-amylase and can be used as therapeutic purposes. In this review our efforts have been devoted to explore the mechanism based carbohydrates-hydrolyzing enzymes Inhibitors for the regulation of diabetes.
Field programmable gate array simulation and study on different multiplexer hardware for electronics and communication Kumar, Arvind; Kumar, Adesh; Agrawal, Anurag Vijay
Computer Science and Information Technologies Vol 6, No 1: March 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/csit.v6i1.p28-39

Abstract

Multiplexing is the technique of transmitting two or more separate signals concurrently using a single communication channel. Multiplexing enables the augmentation of communication channels and consequently the volume of data that may be transmitted. Communication networks utilize diverse multiplexing techniques. An input multiplexer amalgamates various network signals into a singular composite signal before transmission over a shared medium. The composite signal is broken back into its component signals by a demultiplexer, when it reaches its destination, allowing further operations to utilize them separately. The design of the hardware chip depends on the configuration of the multiplexer and demultiplexer in the communication system. The work is presented as a study of the digital logic design and simulation of the different configurations of the multiplexer hardware. The performance evaluation is carried out on the different series of Xilinx field programmable gate array (FPGA) such as Spartan-6, Spartan-3E, Virtex-5, and Virtex-6 with logically checked in Xilinx ISE waveform simulator software. The current analysis of the design and simulation of different configurations of the multiplexer design helps the designers to estimate the chip performance. The novelty of the work lies in its scalable and programmable architecture fitted for specific communication systems that assess performance based on latency, frequency, and power consumption that can be further linked with communication protocols.
Co-Authors Agrawal, Anurag Vijay Amit Roy, Amit Durgeshnandani Sinha, Durgeshnandani Kumar Dewangan, Mehendra Kumar, Adesh Mehendra Kumar Dewangan, Mehendra Kumar Trilochan Satapathy, Trilochan