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All Journal JFL : Jurnal Farmasi Lampung Indonesian Journal of Global Health research Jurnal Pengabdian kepada Masyarakat Nusantara Kartika : Jurnal Ilmiah Farmasi
Dzaki Fikri Firdaus Bakri
Sekolah Tinggi Ilmu Kesehatan Nasional
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Formulation and Characterization of Nanoemulsion from Traditional Extracts for Antidiabetic Dzaki Fikri Firdaus Bakri; Muhtadi Muhtadi; Erindyah Retno Wikantyasning
Indonesian Journal of Global Health Research Vol 5 No 3 (2023): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v5i3.2035

Abstract

Diabetes is a degenerative disease with the highest number of sufferers in the world. Traditional medicine naturally uses extracts of plants and animals in great demand. Curse fish or snakehead fish (Channa striata), elephant lempuyang (Zingiber zerumbet L) and rambutan rind (Nephelium lappaceum) are proven to have active ingredients of albumin, quercetin and geraniin as anti-diabetics. Disadvantages of these active compounds, namely having low solubility, permeability and stability, causing a decrease in bioavailability. Self Nano Emulsifying Drug Delivery System (SNEDDS) is a form of nanoemulsion and is a solution for delivering active compounds to increase permeability, stability and solubility of active compounds. The formula was made using olive oil as the oil phase, PEG 400 as the cosurfactant, span 80, tween 20 and tween 80 as the surfactant. The research aims to obtain the optimum nanoemulsion formula using the HLB method. Percent transmittance and emulsification time are used to determine the optimum formula. The selected formula was further tested with a particle size analyzer, zeta potential, PDI. Based on the 30 formulas that were made, F9 was the chosen formula with an HLB value of 15 with the oil, surfactant, cosurfactant phases at a ratio of 8:1:1. Formula F9 has an emulsification time of 18.76 seconds, a transmittance of 97.8%. The particle size test results were 196.2 nm and -30.1 zeta potential values. The research results showed that SNEDDS preparations were able to form nanoemulsions spontaneously and had good characteristics.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SHEET MASK EKSTRAK DAUN KERSEN (Muntingia Calabura L.) TERHADAP Staphylococcus aureus: FORMULATION AND ANTI BACTERIAL ACTIVITY OF SHEET MASK KERSEN LEAF EXTRACT (Muntingia calabura L.) AGAINST Staphylococcus aureus Bakri, Dzaki Fikri Firdaus; Widya Pangesti, Erma
JFL : Jurnal Farmasi Lampung Vol. 13 No. 1 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i1.1528

Abstract

Jerawat merupakan penumpukan kelenjar minyak pada kulit, disebabkan karena penyumbatan kotoran, dan infeksi bakteri. Bahan alternatif alami yang bisa digunakan untuk anti jerawat yaitu daun kersen (Muntingia calabura L.), mengandung senyawa flavonoid yang dapat mencegah pertumbuhan bakteri Staphylococcus aureus. Daun kersen dapat dibuat menjadi bentuk sediaan sheet mask untuk mempermudah dalam penggunaan sebagai antijerawat. Tujuan penelitian ini untuk mengetahui mutu fisik dan kekuatan hambat dari sheet mask ekstrak daun kersen (Muntingia calabura L.) terhadap bakteri Staphylococcus aureus. Daun kersen diekstraksi dengan pelarut etanol 96% menggunakan metode maserasi kemudian diformulasikan menjadi sheet mask dengan konsentrasi ekstrak daun kersen sebesar 5%, 10%, dan 15%, lalu dilakukan pengujian mutu fisik sediaan meliputi uji organoleptis, uji homogenitas, uji pH, uji viskositas, uji bobot jenis, uji waktu kering, dan uji hedonik serta uji aktivitas antibakteri dengan metode difusi disk. Hasil pengujian mutu fisik sediaan sheet mask ekstrak daun kersen dengan ketiga konsentrasi ekstrak tersebut menghasilkan mutu fisik yang baik dan didapatkan diameter kekuatan hambat bakteri Staphylococcus aureus dari sheet mask ekstrak daun kersen yaitu pada formula 1 sebesar 11,54 ± 0,774 mm, formula 2 sebesar 13,175 ± 1,679 mm dan formula 3 sebesar 14,73 ± 1,024 mm yang termasuk kategori kuat.  
FORMULASI CLAY MASK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DAN UJI INHIBISI Staphylococcus aureus Asthyananda, Michelytha; Bakri, Dzaki Fikri Firdaus
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.680

Abstract

Acne is abnormal skin condition is cause by disruption of oil gland production causees in excessive oil production. One of the bacteria that cause acne is Staphylococcus aureus Binahong leaf (Anredera cordifolia (Ten.) Steenis) has been studied and proven to inhibit Staphylococcus aureus bacteria at 20%. Clay mask is one of pharmaceutical formulations to make it easier for using binahong leaf extract. The purpose of this research is to determine the physical quality test and inhibition activity clay mask with binahong leaf extract against Staphylococcus aureusnbacteria. This study uses the maceration extraction method, formulation of clay mask preparations with a concentration of binahong leaf extract of 10%, 12% and 14%, physical quality tests include organoleptical, homogeneity, pH, viscosity, adhesion, spreadability and drying time of preparations and inhibition Staphylococcus aureus bacteria. The results showed that all clay mask formulas of binahong leaf extract give good physical quality results. The clay mask preparation of binahong leaf extract can inhibition Staphylococcus aureus in formula I is 11,87 ± 0,88, formula II is 13,05 ± 0,44 and formula III is 14,006 ± 1,45. The inhibition activity of the three formulas are classified as strong category.
Inovasi Teknologi Kristalisasi Serbuk Instan Kombinasi Jahe dan Kencur guna Meningkatkan Pengetahuan dan Ketrampilan di Desa Wirun Adiningsih, Retnowati; Setiawan, Iwan; BAKRI, DZAKI FIKRI FIRDAUS
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 4 No. 4 (2023): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN)
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cardiovasculer diseases are the main causes of death in the world with 32% of total deaths. Hypertension is one of the main risk factors for cardiovascular disease, so it needs special attention in society. Ginger (Zingiber officinale Rosc) and galangal (Kaempferia galanga) are medicinal plants and easy to found at home, so it can the best solutions for long term treatment of hypertension. Community service activities were carried out for the Kelompok Wanita Tani (KWT) in Wirun, Mojolaban, Sukoharjo. This research includes analysis of public knowledge regarding hypertension, education on the benefits of product as antihypertensives, education on making crystal powder from ginger and galangal and final evaluation. The results of the research show that this community service activity can produce crystal powder products from ginger and galangal that are easy, cheap and can help lower blood pressure in the people of Wirun Village. This crystal powder products from traditional plants can be a business opportunity for KWT from Wirun as a Produksi Industri Rumah Tangga (PIRT).
Co-Authors Adiningsih, Retnowati Asthyananda, Michelytha Erindyah Retno Wikantyasning Iwan Setiawan Muhtadi Muhtadi Widya Pangesti, Erma