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I. Nyoman Ehrich Lister
Universitas Prima Indonesia
Religion Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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AMELIORATIVE EFFECTS OF HYDROALCOHOLIC OCIMUM BASILICUM LEAF EXTRACT ON BIOCHEMICAL AND HISTOLOGICAL ALTERATIONS IN CISPLATIN-INDUCED CARDIOTOXICITY IN MALE WISTAR RATS Novitasari Tarigan; Feby Dianda; I. Nyoman Ehrich Lister; Edy Fachrial
International Archives of Medical Sciences and Public Health Vol. 6 No. 2 (2025): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v6i2.1393

Abstract

Cardiotoxicity is a common side effect of cisplatin (CIS) chemotherapy, often accompanied by gastrointestinal, renal, and hematological toxicities. This study investigated cardioprotective potential of hydroalcoholic basil leaf extract against CIS-induced toxicity in rats, evaluated through Troponin-T, high-sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), malondialdehyde (MDA) levels, and cardiac histopathology. A quasi-experimental design was employed with eight groups of rats (n = 6 per group): normal, negative control, positive control (vitamin C), and treatment groups receiving basil extract (400 and 800 mg/kg body weight). CIS administration significantly elevated Troponin-T, Hs-CRP, and MDA levels while reducing SOD activity. Treatment with basil extract, particularly at 800 mg/kg, markedly attenuated these changes, restoring biochemical markers toward normal values. Histopathological analysis further confirmed the cardioprotective effect. In conclusion, basil leaf extract demonstrates promising potential as a cardioprotective agent against CIS-induced cardiotoxicity.
AMELIORATIVE EFFECTS OF HYDROALCOHOLIC OCIMUM BASILICUM LEAF EXTRACT ON BIOCHEMICAL AND HISTOLOGICAL ALTERATIONS IN CISPLATIN-INDUCED CARDIOTOXICITY IN MALE WISTAR RATS Novitasari Tarigan; Feby Dianda; I. Nyoman Ehrich Lister; Edy Fachrial
International Archives of Medical Sciences and Public Health Vol. 6 No. 2 (2025): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v6i2.1393

Abstract

Cardiotoxicity is a common side effect of cisplatin (CIS) chemotherapy, often accompanied by gastrointestinal, renal, and hematological toxicities. This study investigated cardioprotective potential of hydroalcoholic basil leaf extract against CIS-induced toxicity in rats, evaluated through Troponin-T, high-sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), malondialdehyde (MDA) levels, and cardiac histopathology. A quasi-experimental design was employed with eight groups of rats (n = 6 per group): normal, negative control, positive control (vitamin C), and treatment groups receiving basil extract (400 and 800 mg/kg body weight). CIS administration significantly elevated Troponin-T, Hs-CRP, and MDA levels while reducing SOD activity. Treatment with basil extract, particularly at 800 mg/kg, markedly attenuated these changes, restoring biochemical markers toward normal values. Histopathological analysis further confirmed the cardioprotective effect. In conclusion, basil leaf extract demonstrates promising potential as a cardioprotective agent against CIS-induced cardiotoxicity.
Co-Authors Edy Fachrial Feby Dianda Novitasari Tarigan