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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Biologica Samudra
Yonadiah Dwitya
Universitas Samudra
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology Physics Veterinary

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Detection and In Silico Study of Neochlorogenic Acid from Rhizophora apiculata Stem Bark Extract as HBV Replication Inhibitors Muhammad Khalil; Yonadiah Dwitya
Jurnal Penelitian Pendidikan IPA Vol 9 No 9 (2023): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i9.5144

Abstract

This study aims to detect and characterize the presence of neochlorogenic acid in Rhizophora apiculata stem bark extract and to examine its potential as an inhibitor of Hepatitis B virus (HBV) replication with in silico approach. This explorative descriptive study used liquid chromatography-mass spectrometry (LC-MS/MS) analysis to detect the content of neochlorogenic acid, and an in silico study through molecular docking analysis using the blind docking technique to test its potential to inhibit HBV replication. LCMS/MS results showed that the neochlorogenic acid was present in R. apiculata stem bark extract which was detected with a peak at 3.94 retention time, and fragment ion with a m/z value of 355.1029. The docking analysis results showed that neochlorogenic acid forms a binding site that is relatively similar to the reference ligand to the HBV capsid protein, involving amino acid residues PHE 23, PRO 25, PHE 110, TYR 118, TRP 102, ILE 139, LEU 140, and SER 141, with binding affinity score -6.3 kcal/mol. Therefore, based on the results of this study, it can be concluded that neochlorogenic acid derived from stem bark extract of R. apiculata has the potential to be used as an alternative treatment for hepatitis B virus infection. 
Potensi Ekstrak Etanol Biji Pinang sebagai Moluskisida Terhadap Keong Mas Hadita Amila; Fitriani; Kartika Aprilia Putri; Yonadiah Dwitya; Mulia Safrida Sari
JURNAL BIOLOGICA SAMUDRA Vol 8 No 1 (2026): Biologica Samudra
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Samudra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33059/jbs.v8i1.14443

Abstract

The golden snail is a major pest in rice cultivation. This pest attacks the vegetative phase of the plant, so that reducing rice production. Various efforts to control gold snail pests have been carried out such as the use of chemical-based molluscicides. However, this can lead to pest resistance and environmental pollution. Therefore, an alternative effort was made by using extracts Areca seed as a molluscicide. The purpose of this study was to determine the effect of ethanol extract of young and old betel nut as a molluscicide and to determine the concentration of ethanol extract of young and old betel nut which was effective as a molluscicide against golden snail pests. The research was carried out at the Universitas Samudra Laboratory in January-March 2021. Experimental design used RAL with 8 treatments and 5 replications. The application of ethanol extract of old betel nut and areca nut had a significant effect on mortality of golden snail pest but was not significantly different between treatments. The application of a single extract of young and old areca nut seeds at a concentration of 30% was very effective in increasing the mortality of golden snails by 100%, both for golden snails aged 14 days, 26 days, 60 days and adult (wild) snails.
Co-Authors Aprilia Kartika Putri Fitriani Hadita Amila Muhammad Khalil Mulia Safrida Sari