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Studi Eksploratif Pemanfaatan Media Pembelajaran Biologi dalam Proses Pembelajaran Hybrid pada Masa Pandemi Covid-19 di SMA Negeri 1 Gorontalo Muh. Nur Akbar; Lilan Dama; Muhammad Khalil
Biologi Edukasi: Jurnal Ilmiah Pendidikan Biologi Vol 13, No 2 (2021): Biologi Edukasi: Jurnal Ilmiah Pendidikan Biologi
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jbe.v13i2.24265

Abstract

Penelitian ini bertujuan untuk mengungkap pemanfaatan media pembelajaran biologi selama proses pembelaajran Hybrid berlangsung di SMA Negeri 1 Gorontalo. Jenis penelitian adalah penelitian deskriptif yang dilakukan di SMA Negeri 1 Gorontalo. Teknik pengumpulan data yaitu menggunakan observasi, wawancara dan kuesioner siswa. Hasil penelitian meunjukkan bahwa proses pembelajaran dilaksanakan secara Hybrid yang diikuti 11 siswa secara luring dan 20 siswa secara daring. Media pembelajaran yang dimanfaatkan dalam proses pembelajaran yaitu video animasi, zoom cloud meeting, lcd proyektor dan media presentasi. Hasil wawancara menunjukkan bahwa media pembelajaran yang digunakan mudah dioperasikan untuk siswa yang luring namun guru mengalami kesulitan untuk siswa yang belajar secara daring. Hasil 80% siswa memperoleh kesulitan dalam proses pembelajaran dan seluruh siswa membutuhkan media pembelajaran berbantuan teknologi untuk menunjajng proses pembelajaran baik secara daring maupun luring. Adapun kesimpulan penelitian ini memberikan rekomendasi pemanfaatan media pembelajaran yang terintegrasi dengan teknologi yang dapat menampilkan gambar bergerak atau video baik secara daring maupun luring dalam waktu bersamaan untuk membantu mengatasi kesulitan belajar siswa.
Pengaruh Pemberian Limbah Kulit Kopi (Coffea sp.) Amoniasi Sebagai Pakan Alternatif Terhadap Pertambahan Bobot Ayam Broiler Muhammad Khalil
Jurnal Ilmiah Mahasiswa Pendidikan Biologi Vol 1, No 1 (2016): Agustus 2016
Publisher : Jurnal Ilmiah Mahasiswa Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.651 KB)

Abstract

The objective of this study was to determined the effect of giving coffee waste ammoniation as alternative feed to body weight of broilers. This study used experimental method with quantitative approach. The study was designed with Completely Randomized Design (CRD) consists of 6 giving treatments contained different concentration of coffee waste ammoniation, consists of P0: Positive Control, P1: 0%, P2: 5%, P3: 10%, P4: 15% and P5: 20% with 4 repetition in each treatment. Factor measured as a parameter in the study was body weight of broilers for 6 weeks as measured by 2nd week, 4th and 6th. The data were analyzed using analysis of variance (ANOVA) α0.05 as well as a further test by Least Significant Difference (LSD) and Honestly Significant Difference (HSD). The results showed that giving coffee waste ammoniation was effected on body weight of broilers. Optimal body weight of broiler in 2nd week was obtained in giving treatment with concentration of 15% coffee waste ammoniation, which average body weight of 512.5 g, for the 4th week of treatment with concentration of 10% which average body weight of 1092.5 g, and for the 6th week of the treatment with a concentration of 15% which average body weight of 1535 g. It was concluded that giving coffee waste ammoniation as much as 15% over 42 days can increase bodu weight of broilers.
Validitas dan Kepraktisan Modul Bioinformatika Berbasis Problem-Based Learning untuk Mahasiswa S2 Biologi Muhammad Khalil; Mohamad Amin; Betty Lukiati
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Vol 5, No 5: MEI 2020
Publisher : Graduate School of Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/jptpp.v5i5.13538

Abstract

Abstract: The aims of this development research are to produce teaching materials in the form of bioinformatics module based on problem-based learning titled analysis of the potential of natural compounds in silico as drug candidates that meet the requirements for validity and practicality to be used in bioinformatics courses. The research method used is research and development method with ADDIE development model which consists of five stages. The validation test result by media experts, material experts, and field practitioners in sequentially obtained the percentage of 98.15%, 91.07%, and 95.97%. The practicality test results obtained a percentage of 87.46%. The conclusion of this development research is the bioinformatics module that has been developed has met the requirements of validity and practicality and can be used without revision.Abstrak: Tujuan dari penelitian pengembangan ini adalah untuk menghasilkan bahan ajar berupa modul bioinformatika berbasis problem-based learning berjudul analisis potensi senyawa alami secara in silico sebagai kandidat obat yang memenuhi syarat kevalidan dan kepraktisan untuk dapat digunakan pada matakuliah bioinformatika. Metode penelitian yang digunakan berupa metode penelitian dan pengembangan (research and development) dengan model pengembangan ADDIE yang terdiri atas lima tahapan. Hasil uji validasi oleh ahli media, ahli materi dan praktisi lapangan secara berurutan diperoleh persentase 98.15%, 91.07%, dan 95.97%. Hasil uji kepraktisan diperoleh persentase 87.46%. Kesimpulan dari penelitian pengembangan ini adalah modul bioinformatika yang telah dikembangkan telah memenuhi syarat kevalidan dan kepraktisan serta dapat digunakan tanpa perlu revisi.
POTENSI SENYAWA BIOAKTIF β-CAROTENE SEBAGAI KANDIDAT ANTIVIRUS HEPATITIS B (THE POTENTION OF BIOACTIVE COMPOUND β-CAROTENE AS ANTI-HEPATITIS B VIRUS CANDIDATE) Muhammad Khalil
Jurnal Geuthèë: Penelitian Multidisiplin Vol 3, No 1 (2020): Jurnal Geuthee : Penelitian Multidisiplin
Publisher : Geuthèë Institute, Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (995.227 KB) | DOI: 10.52626/jg.v3i1.73

Abstract

Hepatitis B adalah penyakit yang disebabkan oleh infeksi virus hepatitis tipe B yang dapat mengakibatkan kerusakan pada sel hati. Penyembuhan dengan penggunaan obat terhadap infeksi ini dalam jangka lama akan menimbulkan resistensi, oleh karena itu diperlukan kajian dan pengembangan senyawa yang dapat digunakan sebagai alternatif dalam pengobatan. β-carotene adalah senyawa bioaktif golongan karotenoid yang memiliki khasiat sebagai obat untuk penyakit metabolik, kardiovaskular, serta penyakit infeksi. Penelitian ini bertujuan untuk mengkaji potensi senyawa bioaktif β-carotene sebagai kandidat antivirus hepatitis B dengan pendekatan in silico. Analisis dilakukan dengan simulasi penambatan molekular antara senyawa β-carotene dengan  protein kapsid virus hepatitis B. Hasil analisis menunjukkan bahwa β-carotene mengikat protein kapsid virus hepatitis B sesuai dengan ligan referensi. Situs pengikatan senyawa melibatkan 17 asam amino dari protein kapsid virus hepatitis B, yaitu LEU D:37, THR D:109, ILE D:105, THR D:33, SER D:106, PHE D:23, ASP D:22, ARG D:133, TYR D:118, PHE D:110, TRP D:102, PHE D:122, ALA D:137, TRP D:125, ILE D:126, PRO D:20, dan LEU D:140. Ikatan yang terbentuk yaitu ikatan van der Waals, alkil dan Pi-alkil. Nilai pengikatan yang diperoleh dari simulasi penambatan molekular adalah -7,9 kkal/mol, lebih rendah dibandingkan dengan ligan referensi sebesar -6,8 kkal/mol. Senyawa β-carotene memiliki potensi sebagai kandidat antivirus hepatitis B.Kata Kunci: Senyawa Bioaktif, β-carotene, Hepatitis B, Antivirus, In SilicoHepatitis B is a disease caused by the hepatitis B virus infection that can cause damage to liver cells. Healing with the use of drugs against this infection, in the long run, will cause resistance, therefore it is necessary to study and develop compounds that can be used as alternatives in treatment. β-carotene is a bioactive compound of the carotenoid group that has efficacy as a drug for metabolic, cardiovascular, and infectious diseases. This study aims to examine the potential of the bioactive compound β-carotene as a hepatitis B antiviral candidate with the in silico approach. The analysis was performed molecular docking simulation between β-carotene and hepatitis B virus capsid protein. The analysis result showed that β-carotene binds to the hepatitis B virus capsid protein according to the reference ligand. The binding site of the compound involves 17 amino acids from the hepatitis B virus capsid protein, LEU D: 37, THR D: 109, ILE D: 105, THR D: 33, SER D: 106, PHE D: 23, ASP D: 22, ARG D: 133, TYR D: 118, PHE D: 110, TRP D: 102, PHE D: 122, ALA D: 137, TRP D: 125, ILE D: 126, PRO D: 20, and LEU D: 140. The bonds formed are van der Waals, alkyl, and Pi-alkyl bonds. The binding value obtained from the molecular docking simulation is -7.9 kcal/mol, lower than the reference ligand of -6.8 kcal/mol. The β-carotene compound has potential as an antiviral candidate for hepatitis B.Keywords: Bioactive compounds, β-carotene, Hepatitis B, Antivirus, In Silico 
ANALISIS POTENSI SENYAWA REPENSOL SEBAGAI KANDIDAT INHIBITOR Muhammad Khalil; Mohamad Amin; Betty Lukiati
Prosiding Seminar Nasional Biotik Vol 8, No 1 (2020): PROSIDING SEMINAR NASIONAL BIOTIK VIII 2020
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh, Aceh, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (678.806 KB) | DOI: 10.22373/pbio.v8i2.9669

Abstract

Penelitian ini bertujuan untuk menganalisis potensi senyawa repensol dalam menginhibisi replikasi virus hepatitis B (HBV) melalui pendekatan in silico dengan menggunakan perangkat komputasi dan perangkat lunak (software). Analisis dilakukan dengan metode simulasi penambatan molekular (Molecular Docking Simulation) yang menggunakan software PyRx, serta divisualisasikan dengan PyMol dan Discovery Studio. Data yang digunakan dalam penelitian yaitu struktur senyawa repensol, protein target berupa protein kapsid HBV, dan ligan referensi berupa 4-methyl heteroaryldihydropyrimidine (4-metil HAP) yang dikoleksi dari database PubChem dan PDB. Hasil docking menunjukkan bahwa ikatan yang terbentuk antara senyawa repensol dengan protein kapsid HBV memiliki nilai binding affinity lebih rendah dari ligan referensi, yaitu -7.0 kkal/mol. Visualisasi menunjukkan senyawa repensol membentuk binding site yang sesuai dengan ligan referensi dan melibatkan 13 residu asam amino dari protein kapsid HBV, yaitu PRO D:138, ILE D:139, SER D:141, PHE D:110, THR D:109, LEU D:37, THR D:33, ILE D:105, PRO D:25, TYR D;118, TRP D:102, LEU D:140, dan PHE D:23. Jenis ikatan yang terbentuk antara senyawa repensol dengan protein kapsid HBV yaitu ikatan van der Waals, hidrogen konvensional, Pi-Sigma, Pi-Pi stacked dan Pi-alkil.
Optimizing Management of the Jeumpa Journal: Journal of Science & Biology Education, Journal of the Biology Education Department, Samudra University Muhammad Khalil; Okhaifi Prasetyo; Muhammad Al Dilwan; Hasby Hasby
JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Vol 7 No 2 (2023): Jati Emas (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat)
Publisher : Dewan Pimpinan Daerah (DPD) Perkumpulan Dosen Indonesia Semesta (DIS) Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36339/je.v7i2.748

Abstract

Scientific journals are publication media that contain articles that present the results of research and scientific studies. Management of journals by departments at universities is essential in improving the quality and reputation of departments, especially in supporting the implementation of tridharma in research. Based on the results of observations, the management of the Jeumpa Journal carried out by the Department of Biology Education at Samudra University is still not optimal. Through the Community Partnership Program (PKM), efforts were made to solve problems related to the not yet optimal management of the journal. Together with Jeumpa Journal editorial partners, efforts to optimize the journal were carried out through four stages, namely optimizing the appearance of the journal's website, compiling author guidelines, compiling article templates, and socializing and promoting the journal. Evaluation with Jeumpa Journal editorial partners on all stages of optimization activities that have been carried out is used as a benchmark in preparing follow-up programs in the development.
NARINGIN'S POTENTIAL AS A HEPATITIS B VIRUS REPLICATION INHIBITOR: AN IN-SILICO STUDY OF SECONDARY METABOLITE COMPOUND Muhammad Khalil; Muh. Nur Akbar; Ardiyas Robi Saputra; Subhan Hadi Kusuma
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8564

Abstract

Naringin is a secondary metabolite compound of the flavonoid group which is generally found in plants that are consumed and traditionally used as medicine. The aim of this study was to examine the potential of naringin as a candidate for hepatitis B virus replication inhibitor using an in-silico approach. This research uses exploratory descriptive method with molecular docking analysis was carried out using the blind docking technique. The 3D structures of naringin and reference ligands were collected from the PubChem database, and the 3D structures of target proteins were collected from the PDB database. The target protein used is the hepatitis B virus capsid protein with PDB ID: 5GMZ. Docking analysis was performed using AutoDock Vina which is integrated into PyRx. Docking results were visualized using the PyMol software and Biovia Discovery Studio 2019. The results of the analysis showed that the binding affinity of all simulation models between naringin and the HBV capsid protein ranged from -7.1 to -7.9 kcal/mol. The binding site formed between naringin and the receptor corresponds to the reference ligand, involving the same 12 amino acid residues, namely PHE 23, PRO 25, LEU 30, THR 33, TRP 102, ILE 105, SER 106, PHE 110, TYR 118, ILE 139, LEU 140, and SER 141. Based on these results, it can be concluded that the naringin compound has the same bioactivity as the reference ligand in inhibiting viral replication, so that naringin has the potential as a candidate for hepatitis B virus replication inhibitor
Detection and In Silico Study of Neochlorogenic Acid from Rhizophora apiculata Stem Bark Extract as HBV Replication Inhibitors Muhammad Khalil; Yonadiah Dwitya
Jurnal Penelitian Pendidikan IPA Vol 9 No 9 (2023): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i9.5144

Abstract

This study aims to detect and characterize the presence of neochlorogenic acid in Rhizophora apiculata stem bark extract and to examine its potential as an inhibitor of Hepatitis B virus (HBV) replication with in silico approach. This explorative descriptive study used liquid chromatography-mass spectrometry (LC-MS/MS) analysis to detect the content of neochlorogenic acid, and an in silico study through molecular docking analysis using the blind docking technique to test its potential to inhibit HBV replication. LCMS/MS results showed that the neochlorogenic acid was present in R. apiculata stem bark extract which was detected with a peak at 3.94 retention time, and fragment ion with a m/z value of 355.1029. The docking analysis results showed that neochlorogenic acid forms a binding site that is relatively similar to the reference ligand to the HBV capsid protein, involving amino acid residues PHE 23, PRO 25, PHE 110, TYR 118, TRP 102, ILE 139, LEU 140, and SER 141, with binding affinity score -6.3 kcal/mol. Therefore, based on the results of this study, it can be concluded that neochlorogenic acid derived from stem bark extract of R. apiculata has the potential to be used as an alternative treatment for hepatitis B virus infection. 
Appsmash Quizizz dan Artificial Intelligence (AI): Teknologi Gamifikasi Pembelajaran Seru dan Interaktif bagi Kelompok MGMP Kimia Kota Langsa Hasby Hasby; Muhammad Khalil; Nurhafidhah Nurhafidhah; Dona Mustika
J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Vol 7, No 2 (2023): Oktober 2023
Publisher : IKIP PGRI Bojonegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30734/j-abdipamas.v7i2.3590

Abstract

ABSTRACTThe Industrial Revolution 4.0 has created major changes in various sectors, including education, with a focus on combining advanced technologies such as AI and IoT with human innovation. This opens up opportunities for more interactive and personalized learning. However, there are still obstacles in adopting this technology in education. Limited resources with skills in utilizing technology in learning is one of the obstacles that must be overcome. This community service activity aims to provide education and workshops for Langsa City Chemistry MGMP teachers regarding the use of Appsmash Quizzizz and artificial intelligence (AI), so that it is hoped that it can improve teachers' skills in adopting technology in learning. This service activity is in partnership with MGMP Kimia Langsa City, involving 17 teachers. This community service is carried out through providing education and workshops on the use of technology in learning, especially AI and Appmash Quizzizz. During the activity, data was collected using pretest and posttest question instruments, observation sheets, and response sheets as activity evaluation materials. The results of the implementation of this service have had a positive impact by increasing partners' skills in adopting technology, especially AI and Appmash Quizizz with a percentage of >75% in all aspects, which include the introduction of AI (88%), use of hardware (76%), AI-based applications online (81%), AI applications in learning (94%), and AI integrated quizizz (87%). The data also shows that the percentage of partner satisfaction with the implementation of this activity reaches >90%. It is hoped that these skills can be habituated in carrying out learning. So, teachers who have skills in using technology will have an impact on the quality of learning, especially in high schools spread across Langsa City.Keywords: Artificial Intelligence, Chemistry MGMP, Interactive Learning, Quizizz. ABSTRAKRevolusi Industri 4.0 telah menciptakan perubahan besar di berbagai sektor, termasuk pendidikan, dengan fokus pada penggabungan teknologi canggih seperti AI dan IoT dengan inovasi manusia. Hal ini membuka peluang untuk pembelajaran yang lebih interaktif dan personal. Namun, masih ada kendala dalam mengadopsi teknologi ini dalam pendidikan. Terbatasnya sumber daya yang memiliki keterampilan dalam memanfaatkan teknologi dalam pembelajaran menjadi salah satu kendala yang harus diatasi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan edukasi dan workshop bagi guru MGMP Kimia Kota Langsa terkait penggunaan appsmash quizizz dan artificial intelligence (AI), sehingga diharapkan dapat meningkatkan keterampilan guru dalam mengadopsi teknologi dalam pembelajaran. Kegiatan pengabdian ini bermitra dengan MGMP Kimia Kota Langsa, dengan melibatkan 17 orang guru. Pelaksanaan pengabdian dilakukan melalui pemberian edukasi dan workshop tentang pemanfaatan teknologi dalam pembelajaran, khususnya AI dan appmash quizizz. Selama kegiatan berlangsung, dilakukan pengumpulan data dengan menggunakan instrumen soal pretest dan postest, lembar observasi, dan lembar respon sebagai bahan evaluasi kegiatan. Hasil pelaksanaan pengabdian ini memberikan dampak positif dengan meningkatkan keterampilan mitra dalam mengadopsi teknologi, khususnya AI dan appmash quizizz dengan persentase >75% pada seluruh aspek, yang meliputi aspek pengenalan AI (88%), penggunaan perangkat keras (76%), aplikasi AI berbasis online (81%), aplikasi AI dalam pembelajaran (94%), dan quizizz terintegrasi AI (87%). Data juga menunjukkan bahwa persentase kepuasan mitra terhadap pelaksanaan kegiatan ini mencapai >90%. Keterampilan ini diharapkan dapat dihabituasikan dalam melaksanakan pembelajaran. Sehingga dengan demikian, guru yang memiliki keterampilan dalam pemanfaatan teknologi akan memberikan dampak pada kualitas pembelajaran, khususnya yang ada di SMA yang tersebar di Kota Langsa. Kata Kunci: Artificial Intelligence, MGMP Kimia, Pembelajaran Interaktif, Quizizz.
Kajian Etnobotani Tanaman Obat Masyarakat Desa Penyangga di Sekitar Taman Nasional Alas Purwo Banyuwangi Mushoffa, Mushoffa; Wijaksono, Agus; Khalil, Muhammad
Jurnal Jeumpa Vol 9 No 2 (2022): Jurnal Jeumpa
Publisher : Department of Biology Education, Faculty of Teacher Training and Education, Samudra University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33059/jj.v9i2.6445

Abstract

Kajian etnobotani memberikan manfaat plasma nutfah yang sangat besar bagi kehidupan salah satunya sebagai sumber pengobatan alami dari alam. Tumbuhan yang dimanfaatkan masyarakat banyak sekali di temukan di ekosistem alami salah satunya di Taman Nasional. Kawasan Taman Nasional Alas Purwo Banyuwangi kaya akan flora dan fauna ada sekitar 584 jenis tumbuhan berpotensi mempunyai khasiat obat yang menghuni konservasi ini terdiri dari rumput, herba, semak dan pepohonan yang masih belum banyak diketahui dan dimanfaatkan oleh masyarakat sekitar taman nasional maupun masyarakat di wilayah Kabupaten Banyuwangi. Tujuan penelitian ini untuk mengetahui jenis, bagian atau organ, dan bagaimana cara pemanfaatan tumbuhan yang digunakan sebagai obat oleh masyarakat desa penyangga di sekitar Taman Nasional alas purwo. Metode penelitian menggunakan metode survey dengan teknik wawancara yang disertai dengan keterlibatan aktif peneliti dalam kehidupan masyarakat setempat Participatory Etnobotanical Appraisal (PEA). Berdasarkan hasil penelitian Terdapat 35 Jenis tumbuhan dari 19 famili yang dimanfaatkan sebagai obat oleh masyarakat desa penyangga Taman Nasional Alas Purwo yakni Desa Kalipait dan Desa Grajagan. Bagian dari tumbuhan yang dimanfaatkan ada 11 bagian diantarannya adalah biji, getah, akar, kulit, batang, dan daun, bunga, umbi, rimpang, buah, dan semua bagian tumbuhan. Masyarakat biasa memanfaatkan cara pemanfaatan tumbuhan diantaranya adalah diparut, digosok, dikucak, ditempel, ditumbuk, direbus, dibungkus, diremas dan diasar.