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All Journal Sriwijaya Journal of Surgery
Nur Qodir
Department of Surgery, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Medicine & Pharmacology

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Effects of Neo-Adjuvant Chemotherapy on CD8 + Serum Levels in Local Advanced Stage Breast Cancer Patients Nopriansyah Darwin; Nur Qodir; Mulawan Umar; Theodorus
Sriwijaya Journal of Surgery Vol. 3 No. 1 (2020): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v3i1.27

Abstract

Introduction: CD8 + CTLs are important components of tumor specific cellular adaptive immunity in breast cancer. Chemotherapy can increase the response of cytotoxic lymphocytes and provide anti-tumor immunity. Therefore, chemotherapy can cause cell death and trigger tumor antigens that are processed by APC and activate CD8 + cells to destroy tumor cells. Evaluation of the immune system before treatment can predict chemotherapy response. The purpose of this study was to assess the effect of neo-adjuvant chemotherapy on serum CD8 + levels in patients with locally advanced breast cancer. Methods: Non-comparative clinical trials were conducted at Dr. Mohammad Hoesin Hospital Palembang from October 2017 to June 2018.The sample of this study was 30 breast cancer patients who met the inclusion criteria. All samples underwent FAC neo-adjuvant chemotherapy and data were analyzed with SPSS version 21. Results: The mean age of advanced breast cancer patients was 45.97 ± 10,526 years with an age range of 30-66 years. Serum CD8 + levels after chemotherapy decreased significantly compared to before chemotherapy (p = 0.000). The value of serum CD8 + before chemotherapy has a sensitivity of 42.86% and specificity of 43.48% with a cut of point of 660.7 cells / mm3. Conclusion: Neo-adjuvant chemotherapy significantly decreases serum CD8 + levels in local advanced breast cancer patients.
Comparison of Scar Modified Radical Mastectomy Surgery Using Songket Technique and Standard Technique in Dr. Mohammad Hoesin General Hospital in Palembang Iqmal Perlianta; Rangga Kusuma Maulana; Mufida Muzakkie; Nur Qodir; Erial Bahar
Sriwijaya Journal of Surgery Vol. 3 No. 2 (2020): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v2i2.31

Abstract

Introduction: Lateral ear dogs and loss of anterior axillary fold are side effects of modified radical mastectomy (MRM) operations and are cosmetically unpleasant. Songket technique is expected to reduce the side effects of MRM surgery. This study compared the Modified Radical Mastectomy surgery scar using Songket and standard techniques. Methods: This research is a clinical randomized trial. With anterior chest thoracic data of postoperative patients and assessed by the patient's family and medical professionals using a likert scale on wound length, wound width, wound angle and armpit folding. This study was performed in the Department of Surgery Mohammad Hoesin Hospital Palembang from January 2020 to April 2020. Results: A total of 32 research subjects participated with the average Likert scale score on medical and family assessments between the Songket and standard technique groups with p values ​​of 0.605 and 0.984, respectively. Conclusion: There was no difference in comparison of scar Modified Radical Mastectomy operations using Songket techniques and standard techniques at Mohammad Hoesin Hospital in Palembang.
Co-Authors Erial Bahar Iqmal Perlianta Mufida Muzakkie Mulawan Umar Nopriansyah Darwin Rangga Kusuma Maulana Theodorus Theodorus