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All Journal Sriwijaya Journal of Surgery
Mulawan Umar
Department of Surgery, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Medicine & Pharmacology

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Effects of Neo-Adjuvant Chemotherapy on CD8 + Serum Levels in Local Advanced Stage Breast Cancer Patients Nopriansyah Darwin; Nur Qodir; Mulawan Umar; Theodorus
Sriwijaya Journal of Surgery Vol. 3 No. 1 (2020): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v3i1.27

Abstract

Introduction: CD8 + CTLs are important components of tumor specific cellular adaptive immunity in breast cancer. Chemotherapy can increase the response of cytotoxic lymphocytes and provide anti-tumor immunity. Therefore, chemotherapy can cause cell death and trigger tumor antigens that are processed by APC and activate CD8 + cells to destroy tumor cells. Evaluation of the immune system before treatment can predict chemotherapy response. The purpose of this study was to assess the effect of neo-adjuvant chemotherapy on serum CD8 + levels in patients with locally advanced breast cancer. Methods: Non-comparative clinical trials were conducted at Dr. Mohammad Hoesin Hospital Palembang from October 2017 to June 2018.The sample of this study was 30 breast cancer patients who met the inclusion criteria. All samples underwent FAC neo-adjuvant chemotherapy and data were analyzed with SPSS version 21. Results: The mean age of advanced breast cancer patients was 45.97 ± 10,526 years with an age range of 30-66 years. Serum CD8 + levels after chemotherapy decreased significantly compared to before chemotherapy (p = 0.000). The value of serum CD8 + before chemotherapy has a sensitivity of 42.86% and specificity of 43.48% with a cut of point of 660.7 cells / mm3. Conclusion: Neo-adjuvant chemotherapy significantly decreases serum CD8 + levels in local advanced breast cancer patients.
The Influence of Progressive Muscle Relaxation (PMR) on the Improvement of Body Composition, Depression Status and Quality of Life of Breast Cancer Patients During Chemotherapy in Dr. Mohammad Hoesin General Hospital Palembang Ronaldoe B; Mulawan Umar; Irfannuddin
Sriwijaya Journal of Surgery Vol. 3 No. 2 (2020): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v2i2.35

Abstract

Background: The breast cancer progression and chemotherapy side effects not only cause problems in mental status, but also the patient's physical status. This is related to a deteriorating quality of life and a worse prognosis. Physical exercise can improve physical status, mental status, and quality of life. Methods: Experimental pre- and post intervention research with a control group was conducted on breast cancer patients to determine the effect of progressive muscle relaxation on the improvement of body composition, depression status, and quality of life for breast cancer patients during chemotherapy at RSMH on February 2019 - February 2020. Results: Progressive muscle relaxation (PMR) can improve body composition (p = 0.000), reduce the degree of depression (p = 0.000), improve global health status (p = 0.013), physical functioning (p = 0.002), emotional functioning (p = 0.009), social functioning (p = 0015), body image (0.000), sexual function (p = 0.05), future perspective (p = 0.006), and decreased fatigue (p = 0.00), nausea and vomiting (p = 0.002 ), pain (0.000), insomnia (0.002), appetite loss (p = 0.000), breast symptoms (p = 0.000), arm symptoms (p = 0.000), hair loss (p = 0.000), and therapy side effects (p = 0.000). Conclusion: Progressive muscle relaxation has a significant effect on improving body composition, depression status, and quality of life for breast cancer patients during chemotherapy.
Co-Authors Irfannuddin Nopriansyah Darwin Nur Qodir Ronaldoe B Theodorus Theodorus