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All Journal HAYATI Journal of Biosciences
Dionisius Denis
Exeins Health Initiative, Jakarta 12870, Indonesia
Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences

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α-Mangostin Effectively Inhibits Chikungunya Virus Replication in HepG2 Cells Moudy Soraya; Justus Sievers; Dionisius Denis; Anom Bowolaksono; R. Tedjo Sasmono
HAYATI Journal of Biosciences Vol. 30 No. 6 (2023): November 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.6.1187-1193

Abstract

Chikungunya virus (CHIKV) is an arthropod-transmitted Alphavirus endemic to countries in Africa and Asia, including Indonesia, which causes debilitating arthralgia which can last several years. The rapid spread of CHIKV to new areas makes the discovery of antiviral agents a high priority. α-mangostin is a xanthone from mangosteen (Garcinia mangostana) pericarp and has antiviral activity against Hepatitis C and Dengue viruses. We investigated the antiviral activity of α-mangostin against CHIKV in HepG2 cells in pre-, post- and combination treatments compared to the common antiviral medicine ribavirin, as well their cytotoxicity. Our results show dose-responsive reductions in viral titer in all treatment regimes, with post- and combination treatments being more effective than pre-treatment only (IC50 = 7.79, 5.99 and 6.39 µM, respectively), but with poor specificity (SI = 1.39, 1.81 and 1.70, respectively) compared to ribavirin. Neither compound showed a direct virucidal effect. These results suggest α-mangostin effectively inhibits CHIKV replication in this cell line.
Co-Authors ANOM BOWOLAKSONO Justus Sievers Moudy Soraya R. Tedjo Sasmono