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All Journal ad-Dawaa : Journal of Pharmaceutical Sciences
Khazanah Nurain
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Antibacterial Activity of Jackfruit Leaf (Artocarpus Heterophyllus LMK.) Ethanol Extract Gel on Propionibacterium acnes Fitrya Fitrya; Elsa Fitria Apriani; Adik Ahmadi; Dina Permata Wijaya; Khazanah Nurain
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.37608

Abstract

Introduction: Artocarpus heterophyllus LMK. leaves contain flavonoids, tannins, and saponins, which have the potential to be antibacterial. Aims: This study aims to test the antibacterial activity of A. heterophyllus leaves ethanol extract, which is formulated in a gel preparation. Methods: Antibacterial testing was done on the acne-causing bacteria Propionibacterium acnes. The gel formula is designed with an extract concentration of 5, 10, or 15% with Carbopol 940 and HPMC as the bases. The antibacterial activity test was carried out using the well diffusion method. Result: The results of the study showed that the concentration of the extract affected pH, adhesive power, removability, and viscosity. Antibacterial activity tests showed that the gel of A. heterophyllus extract could inhibit Propionibacterium acnes bacteria. The higher the concentration of the extract, the greater the antibacterial activity. Conclusion: It can be concluded that the gel with an extract concentration of 15% gave the strongest antibacterial activity with an inhibition zone of 10.9 ± 1.18 mm.
Co-Authors Adik Ahmadi Dina Permata Wijaya Elsa Fitria Apriani Fitrya .