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All Journal MASALIQ: Jurnal Pendidikan dan Sains OKTAL : Jurnal Ilmu Komputer dan Sains
Muhammad Chandra
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Religion Astronomy Chemistry Computer Science & IT Education Electrical & Electronics Engineering Social Sciences

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PENERAPAN METODE AGILE DALAM MANAGEMEN PROYEK TEKNOLOGI INFORMASI Bastian Aji Prihantoro; Ariska Fauzi; Dennis Eka Putra; Muhammad Chandra; Rizky Ashiddiqia
OKTAL : Jurnal Ilmu Komputer dan Sains Vol 3 No 03 (2024): OKTAL : Jurnal Ilmu Komputer Dan Sains
Publisher : CV. Multi Kreasi Media

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Abstract

The development of information technology and the management of future information technology projects can help practitioners and academics to understand more about the application of agile methods in the management of information technology projects. It is also hoped to provide insights into how the management of information technology projects can be integrated with agile methods so that they can help improve efficiency and be effective but, to implement agile methods in information technology projects effectively, strong project management skills, active involvement of clients, and appropriate adaptation to the project.
Peningkatan Kualitas Aplikasi dengan Pengujian Fungsional Menggunakan Robot Framework David Kurniawan; Muhammad Chandra; Aries Saifudin
OKTAL : Jurnal Ilmu Komputer dan Sains Vol 3 No 06 (2024): OKTAL : Jurnal Ilmu Komputer Dan Sains
Publisher : CV. Multi Kreasi Media

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Abstract

Functional testing is an important stage in aplikasi development cycle aimed at ensuring that the application works correctly and meets the specifications. However, manual functional testing can be a tiring task and prone to human errors. Therefore, this research attempts to improve aplikasi quality by using Robot Framework as an automated functional testing tool. Robot Framework is an open-source automated testing framework that can be used to test desktop and web applications easily. The research method used is an experiment comparing the results of manual and automated functional testing on the same application. The results show that automated functional testing with Robot Framework can reduce the time required for testing, improve testing efficiency, and produce more accurate testing reports. Therefore, the use of Robot Framework as a functional testing tool can improve aplikasi quality by reducing human errors and improving testing efficiency.
Studi In Silico Turunan Imidazopirimidin sebagai Agen Antikanker Payudara terhadap Protein ER-α, ADMET, dan Drug-Likeness Muhammad Chandra; Fajriah Azra
MASALIQ Vol 6 No 4 (2026): JULI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i4.10974

Abstract

Breast cancer is one of the leading causes of global mortality, requiring the development of new therapeutic agents that are more effective and selective. This study aims to evaluate the potential of 20 imidazopyrimidine derivative compounds as candidate selective inhibitors of Estrogen Receptor Alpha (ER-α). This study used an in silico approach that included molecular docking using MOE 2019.0102 software with ER-α target protein (PDB ID: 3ERT), followed by drug-likeness screening based on Lipinski’s Rule of Five and prediction of the ADMET pharmacokinetic profile through the SwissADME and pKCSM web servers. The molecular docking results showed that Compound 15 had the strongest binding affinity, with a docking score (S) of -11.94 kcal/mol and a Root Mean Square Deviation (RMSD) value of 0.7 Å, better than the control ligand 4-hydroxytamoxifen (S = -11.1 kcal/mol; RMSD = 1.8 Å). Other potential compounds that showed high affinity were Compound 13 (S = -11.20 kcal/mol) and Compound 1 (S = -10.88 kcal/mol). The ligand-protein complex was stabilized by hydrogen bonds, hydrophobic interactions, and pi-sulfur interactions in the receptor’s active pocket. Physicochemical prediction showed that most compounds met Lipinski’s Rule of Five criteria for oral drug candidates and had good ADMET solubility, permeability, and elimination profiles without indications of hepatotoxicity. The conclusion of this study affirms that imidazopyrimidine derivatives, particularly Compounds 15, 13, and 1, have potential as candidate ER-α-targeted breast anticancer agents. These findings provide an initial contribution to the development of breast anticancer therapy candidates and need to be followed up through experimental in vitro and in vivo studies.
Co-Authors Aries Saifudin Ariska Fauzi Bastian Aji Prihantoro David Kurniawan Dennis Eka Putra Fajriah Azra Rizky Ashiddiqia