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All Journal Medula Jurnal Biologi Tropis
Nisa Karima
universitas lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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MINYAK NABATI SEBAGAI PENGGANTI BAHAN KIMIA TOKSIK PADA PROSES CLEARING JARINGAN HISTOPATOLOGI Balqis Mezzaluna D'Azzuri; Susianti Susianti; Nisa Karima
Medula Vol 13 No 6 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i6.813

Abstract

The clearing stage is an important step in preparing tissue histology to be examined under a light microscope, clearing is done to clean the tissue so that it is possible to insert it with an embedding material. Xylene is the material most widely used because of its excellent compatibility with fixing materials such as alcohol and paraffin. However, xylene is known to have various toxic effects on the exposed body. Many alternative materials have been found to replace xylene as a clearing agent in the process of making histopathological tissues. These ingredients are vegetable oils including coconut oil, peanut oil, olive oil, palm oil, and corn oil. These materials can be used as clearing agents without affecting the histological tissue composition, are more affordable, and do not cause health problems.
Analysis of Antibacterial Test and Brine Shrimp Lethality Test from Extract Sponge Derived Fungi Oktora Susanti; Nisa Karima; Ervina Damayanti
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12101

Abstract

Bacterial resistance to antibiotics has increased the demand for new antibacterial agents from natural sources, including marine organisms. This study evaluated the antibacterial activity and toxicity of sponge-associated fungal extracts. Antibacterial activity against Escherichia coli was tested using the disc diffusion method, while toxicity was assessed using the Brine Shrimp Lethality Test (BSLT). The extract was obtained by maceration with 95% methanol and tested at various concentrations. The extract showed antibacterial activity, with the largest inhibition zones at 100 and 1,000 ppm after 24 hours, which decreased after 48 hours. BSLT results showed 100% mortality of Artemia salina larvae at concentrations ≥100 ppm. The main BSLT test revealed a dose–response relationship, with higher doses and longer exposure reducing larval survival. These results indicate that sponge- associated fungal extracts are promising antibacterial agents, although their toxicity requires further evaluation.
Co-Authors Balqis Mezzaluna D'Azzuri Ervina Damayanti Oktora Susanti Susianti Susianti