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All Journal Dentino: Jurnal Kedokteran Gigi Yarsi Dental Journal
Dahlia Herawati
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Dentistry

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EFFECT OF COENZYME Q10 APPLICATION ON POST GINGIVAL CURETTAGE: TRANSFORMING GROWTH FACTOR-β1 LEVEL (TGF-β1) IN GINGIVAL CREVICULAR FLUID Dahlia Herawati
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17527

Abstract

Background: Curettage is one of the common periodontitis treatments. Mechanical cleaning of periodontal pocket requires additional materials so the wound healing in the operating area is more optimal. Coenzyme Q10 is one of the ingredients can be used to control levels of Reactive Oxygen Species (ROS). Coenzyme Q10 concentrations of 1:9 and 2:8 in previous studies have been shown to stimulate fibroblast proliferation but its impact on TGF-β1 levels is still unknown. Purpose: to compare the effect of Coenzyme Q10 concentrations 1:9 and 2:8 with PerioQTM on TGF-β1 expression post-curettage. Method: In vivo, study was conducted on 12 periodontitis induced - Oryctolagus cuniculus. Coenzyme Q10 concentrations 1:9 (group I) and 2:8 (group II) were applied post-curettage and the results were compared with PerioQTM (group III). The TGF-β1 was collected from gingival sulcus fluid. It was taken with paper point no. 15 on days 3, -7, and -14 followed by Enzyme-Linked Immunosorbent Assay (ELISA) examination. Data were analyzed with Two-way ANOVA and post hoc test with a significance level of p<0.05. Result: TGF-β1 levels after application of Coenzyme Q10 concentration 1:9 and PerioQTM reached the peak on day 7 and decreased on day 14 while Coenzyme Q10 concentration of 2:8 reached the peak on day 14. Conclusion: The application of these three ingredients affects TGF-β1 levels of gingival sulcus fluid. The expression pattern of TGF-β1 concentration 1:9 is similar to PerioQTM, which reaches a peak at 7 days post-curettage and decreases the day after.  Keywords: Coenzyme Q10, Gingival Crevicular Fluid, Periodontitis-Induced, Transforming Growth Factor-β1, Ubiquinone
MODIFIKASI TEKNIK INSISI ABERRANSIA FRENULUM SEBELUM PERAWATAN ORTODONTIK: LAPORAN KASUS pritama, muhammad_fauzi_adityawan; Dahlia Herawati
YARSI Dental Journal Vol. 2 No. 2 (2025): YARSI DENTAL JOURNAL
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ydj.v2i2.226

Abstract

Abstract Introduction: High labial frenulum attachment affects periodontal tissue to gingivitis and central diastema that interfere aesthetic function, so frenectomy treatment is needed. Frenectomy with convensional technique using blade had a wide wound because attraction of lip muscles and cause a lot of bleeding. Minimal bleeding can be achieved by modifying frenectomy with Incision Below the Clamp (IBC). The objective of this paper was to report frenectomy treatment with IBC technique can minimize bleeding. Case History: A 21-year-old woman came to the Periodontics Clinic of Prof. Soedomo Dental and Oral Hospital UGM with chief complaint of gapped upper front teeth that interfered appearance. After examination, there was aberration labial frenulum superior cause central diastema. Treatment planned before diastema closure was frenectomy with IBC technique using clamp with parallel positition and attached to labial mucosa, then incision under the clamp to base of vestibule and suturing in mucolabial fold. Discussion: Frenectomy with IBC technique made small wounds on the labial mucosa because the attraction of the orbicularis oris muscle laterally was hold back by clamp and suturing immediately after incision will hold muscle attraction after clamp was release and reduced bleeding. Surgery with few bloods will provide a sense of calm and comfort for patient and dentist. Conclusion: Frenectomy for aberrantia frenulum labialis superior using IBC technique completely remove the frenulum and orthodontic treatment can be continued. Key Words: Aberrant frenulum, frenectomy, Incision Below the Clamp, central diastema, musculus orbicularis oris
Co-Authors pritama, muhammad_fauzi_adityawan