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Sainal Edi Kamal
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Activity of Horseshoe Leaf Extract (Ipomoea pescaprae L.) As Analgesic and Antipyretic in Mice (Mus musculus) Sainal Edi Kamal; Firmansyah Firmansyah; Rusli Rusli; Gerfan Patandung
Jurnal Farmasi Sandi Karsa Vol 7 No 2 (2021): Jurnas Farmasi Sandi Karsa (JFS)
Publisher : Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36060/jfs.v7i2.84

Abstract

Analgesics or painkillers are substances that reduce or eliminate pain without losing consciousness (in contrast to general anesthetics while antipyretics are drugs or substances that can reduce body temperature in a feverish state. This study aims to determine the activity of leaf extracts Tapak Kuda (Ipomoea pescaprae L.) as an analgesic and antipyretic in mice (Mus musculus) and to determine the dose of ethanol extract of Tapak Kuda leaf which has analgesic and antipyretic effects. The method used was sample extraction by maceration using 96% ethanol solvent and extract The results obtained were divided into 3 concentrations, namely 100, 300, and 500 mg/kgBW mice, then paracetamol was used in the positive control group. In the analgesic study, acetic acid was used as a pain inducer and in the antipyretic study, 10% peptone was used as a fever inducer. Male mice 15 adults used g were divided into 5 groups and each group consisted of 3 tails. Group I was treated with 1% Na-CMC as a negative control. Group II positive control of paracetamol with treatment given orally at a dose of 1 ml/30 grams of body weight to mice. Groups III, IV, and V as the test group were given ethanol extract of the leaves of Tapak Kuda (Ipomoea pescaprae L.) with extract doses of 100, 300 and 500 mg/kg BW with a volume of 1 ml / 30 gram BW. The results showed that in the analgesic test the administration of the ethanol extract of the leaves of Tapak Kuda (Ipomoea pescaprae L.) with extract doses of 300 mg/kgBW and 500 mg/kgBW could provide an analgesic effect, while the results of the antipyretic test on the administration of the ethanolic extract of the leaves of Tapak Kuda (Ipomoea pescaprae L.) with extract doses of 100, 300, and 500 mg/kgBW also had antipyretic effects.
Potential of Pineapple (Ananas comocus (L.) Merr.) Flesh as a Laxative in Mice (Mus muscullus) Sainal Edi Kamal; Muhammad Saharuddin; Jumrah Jumrah
Jurnal Farmasi Sandi Karsa Vol 9 No 1 (2023): Jurnal Farmasi Sandi Karsa (JFS)
Publisher : Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36060/jfs.v9i1.122

Abstract

The pineapple plant, Ananas comocus (L) Merr, has growing shoots at the base that grow into a midrib. The sword-like leaves are strong and substantial. For defecation, the bromelin enzyme, which is contained in pineapples, is frequently used as a laxative (constipation). The purpose of this study was to ascertain the laxative effects of pineapple flesh (Ananas comocus (L) Merr.) extract and the dosages at which it was effective. The Pharmacology Laboratory, Faculty of Mathematics and Natural Sciences, Pancasakti University, used an experimental study design. In this investigation, 25 mice were employed, split into 5 groups, starved for 1 hour, and then given loperamide to induce behavior. Na. CMC was used as a negative control in the first group, pineapple flesh extract was utilized in the second, third, and fourth groups at doses of 100 mg, 300 mg, and 500 mg, and dulcolactol was used as a positive control in the third and fifth groups. The Kruskal-Wallis test was used to examine the study's data and findings. According to the study's findings, pineapple flesh extract has a laxative effect. A dose of 500 mg is the laxative that works the best, with an average 2,1
Co-Authors Firmansyah Firmansyah Gerfan Patandung Jumrah Jumrah Muhammad Saharuddin Rusli Rusli