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All Journal Indonesian Journal of Global Health research Indonesian Journal of Global Health Research
Jelita Siregar
Universitas Sumatera Utara
Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health

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Corelation Between Uric Acid and Neutrophil Lymphocyte Ratio (NLR) in Controlled and Uncontrolled Type 2 Diabetes Mellitus Immanuel Situmorang; Jelita Siregar; Santi Syafril
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6986

Abstract

Type 2 diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia, often linked to metabolic complications and inflammatory conditions. Uric acid and Neutrophil-Lymphocyte Ratio (NLR) are biomarkers of inflammation and oxidative stress in this condition. This study aims to examine the relationship between uric acid and NLR in controlled and uncontrolled type 2 DM patients. Using an analytical observational design with a cross-sectional approach and consecutive sampling, 112 subjects were divided into controlled (HbA1c < 7%) and uncontrolled (HbA1c ≥ 7%) groups. Data were collected from RSUP H. Adam Malik Medan through laboratory tests for whole blood, uric acid, and HbA1c levels. Pearson or Spearman correlation tests were used to assess relationships between variables with a significance level of p < 0.05. Significant demographic differences were found between groups, with higher uric acid and HbA1c levels in the uncontrolled DM group. Positive correlations were observed between uric acid and NLR, as well as uric acid and HbA1c, in both groups. Additionally, a strong positive association between HbA1c and NLR was found in both groups. Uric acid, NLR, and HbA1c are correlated in both controlled and uncontrolled type 2 diabetes mellitus.
Analysis of the Relationship Between Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Red Blood Cell Distribution Width (RDW) With Colorectal Cancer Staging Mei Vrayanti F.S; Jelita Siregar; Adi Muradi Muhar
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1449

Abstract

This study aimed to examine the relationship between the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW) with colorectal cancer (CRC) staging. Colorectal cancer is one of the most prevalent malignancies worldwide and a leading cause of cancer-related mortality, particularly in Indonesia. Inflammation plays an important role in cancer progression, and systemic inflammatory markers such as NLR, PLR, and RDW are considered practical, accessible, and cost-effective indicators for assessing disease severity and prognosis. An observational analytic study with a cross-sectional design was conducted at H. Adam Malik General Hospital, Medan, from November 2024 to January 2025. A total of 56 newly diagnosed CRC patients who had not undergone surgery or chemotherapy were enrolled using consecutive sampling. Blood samples were analyzed using a Sysmex XN-1500 hematology analyzer. Statistical analyses included independent t tests, Mann–Whitney tests, Spearman correlation, and receiver operating characteristic (ROC) analysis. The results demonstrated a significant difference in PLR values between early- and advanced-stage CRC (p = 0.003), with a moderate positive correlation between PLR and cancer stage (r = 0.297, p = 0.026). RDW showed a weak but statistically significant correlation with CRC stage (r = 0.284, p = 0.034). In contrast, NLR did not show a statistically significant correlation with CRC staging (p = 0.109). These findings suggest that PLR and RDW are promising, simple, and inexpensive inflammatory biomarkers that may assist in the preoperative staging of colorectal cancer, whereas NLR alone may not be a reliable predictor of CRC stage.
Co-Authors Adi Muradi Muhar Immanuel Situmorang Mei Vrayanti F.S Santi Syafril