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All Journal Respiratory Science
Elvando Tunggul Mauliate Simatupang
Department of Pulmonology and Respiratory Medicine Faculty of Medicine, University of Riau
Health Professions Medicine & Pharmacology

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Immunopathogenesis of Silicotuberculosis: A Literature Review Indi Esha; Elvando Tunggul Mauliate Simatupang
Respiratory Science Vol. 4 No. 1 (2023): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i1.103

Abstract

Silicotuberculosis is a tuberculosis infection that emerges as a silicosis complication. A silicosis patient is 2.8 to 39 times more likely to develop pulmonary tuberculosis (TB). Moreover, the fibrotic condition caused by silicosis may exacerbate the symptoms and worsen the clinical outcome of silicotuberculosis patients.  The current report suggests that the immune system plays an important role in the pathogenesis of this disease. Silicosis or silica exposure might interfere with the immunological response, especially the macrophages, which permit the Mycobacterium tuberculosis to infect the host. In this literature review, we will discuss the definition, epidemiology, and immunopathogenesis of silicotuberculosis.  
Co-Authors Indi Esha