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Resti Gradia Dwiwina

University Of Padjadjaran

Author-ID : 664520

Chemistry Health Professions Medicine & Pharmacology Physics Public Health

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Characteristics of Malignant Eyelid Basal Cell Carcinoma in Cicendo Eye Hospital Bandung from 2013 to 2015 Hui, Yee She; Kartiwa, Raden Angga; Dwiwina, Resti Gradia
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

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Background: Basal cell carcinoma (BCC) has been proved to have the highest incidence among eyelid malignancies. Basal cell carcinoma is the most common invasive cancer in humans. It is capable of causing extensive tissue destruction. The aim of the study was to identify the characteristics of adult patients with malignant eyelid BCC in Cicendo Eye Hospital Bandung.Methods: A descriptive retrospective study was conducted to determine the characteristics of adult patients with malignant eyelid BCC in Cicendo Eye Hospital Bandung from March 2013 to October 2015. Age and sex distribution of the lesions, location and histopathological results of the tumors were stratified as variables. The inclusion criteria were patients over age of 20, histopathologically diagnosed with periocular BCC. Results: A total of 37 cases histopathologically diagnosed with periocular BCC were evaluated. Females had a slight predominance. The mean age was 61.7 years. The most common site was on the lower lid. The tumors occurred more on the left side. The most common histological subtype was represented by solid growth pattern.Conclusions: The majority of periocular BCC cases occur in females and elderly. Most tumors develop on the lower lid with a left-side preference and have a solid growth pattern histologically. [AMJ.2017;4(1):148â51]Â DOI:Â 10.15850/amj.v4n1.1037

Characteristics of Malignant Eyelid Basal Cell Carcinoma in Cicendo Eye Hospital Bandung from 2013 to 2015 Yee She Hui; Raden Angga Kartiwa; Resti Gradia Dwiwina
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (85.832 KB)

Background: Basal cell carcinoma (BCC) has been proved to have the highest incidence among eyelid malignancies. Basal cell carcinoma is the most common invasive cancer in humans. It is capable of causing extensive tissue destruction. The aim of the study was to identify the characteristics of adult patients with malignant eyelid BCC in Cicendo Eye Hospital Bandung.Methods: A descriptive retrospective study was conducted to determine the characteristics of adult patients with malignant eyelid BCC in Cicendo Eye Hospital Bandung from March 2013 to October 2015. Age and sex distribution of the lesions, location and histopathological results of the tumors were stratified as variables. The inclusion criteria were patients over age of 20, histopathologically diagnosed with periocular BCC. Results: A total of 37 cases histopathologically diagnosed with periocular BCC were evaluated. Females had a slight predominance. The mean age was 61.7 years. The most common site was on the lower lid. The tumors occurred more on the left side. The most common histological subtype was represented by solid growth pattern.Conclusions: The majority of periocular BCC cases occur in females and elderly. Most tumors develop on the lower lid with a left-side preference and have a solid growth pattern histologically. [AMJ.2017;4(1):148–51] DOI: 10.15850/amj.v4n1.1037

Curcuma longa L. Prevents Hepatotoxicity Induced Isoniazid and Rifampicin: An Experiment in Wistar Rats Model Rahman, Putri Halleyana; Dwiwina, Resti Gradia; Pratiwi, Yuni Susanti; Bashari, Muhammad Hasan
Althea Medical Journal Vol 11, No 2 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n2.3161

Background: Hepatotoxicity induced by the combination of isoniazid (INH) and rifampicin (RIF) in the treatment of tuberculosis (TB) remains a major concern. Oxidative stress has a role in mechanism of hepatotoxicity. Curcuma longa L. has been widely used as a traditional medicine and has shown antioxidant activity. This study aimed to provide evidence of Curcuma longa L as protection against oxidative stress induced by isoniazid and rifampicin therapy.Methods: This was an experimental study on male Wistar rats weighing 150-200 grams, aged 8-10 weeks which were divided into a negative control group (K0), a positive control group with INH + RIF (K1), a treatment group with a dose of 2.2 gr/kg/day Curcuma longa L powder (K2), and treatment group with INH+RIF and additional 2.2 gr/kg/day turmeric rhizome powder (K2+). SGOT and SGPT were measured from blood plasma on the 28th day; then hepatic tissue was obtained to measure MDA levels and observed histologically. Statistical analysis was done using ANOVA and continued with Duncan procedure using SPSS ver. 27.Results: SGOT, SGPT, the highest average MDA level in the liver, and the highest mean necrotic cell count in the positive control group showed a significant difference (p<0.05). The treatment group had a smaller average number of necrotic cells than the positive control group with a significant difference (p <0.05).Conclusion: Curcuma longa L powder has been shown to prevent elevation in SGOT, SGPT, MDA of liver tissue and hepatocyte necrosis, indicating its potential in protecting the liver from oxidative stress.

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