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Syamsurizal Syamsurizal
Jurusan Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi, Jambi, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Kajian aktivitas antioksidan pada isolat akar dan buah palem merah (Cyrtostachys renda Blume) dengan metode DPPH Syamsurizal Syamsurizal; Puspa Dwi Pratiwi; Ria Novia; Sarah Dianora Sitanggang; Amalia Rani; Mira Ovita Damayani
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.407

Abstract

Free radical reactions were increased in cells, leading to degenerative illnesses. Antioxidant components may inhibit free radical reactions. Exogenous antioxidants are primarily found in red palm (Cyrtostachys renda Blume). This study aimed to assess the potency of antioxidant activities of fruit and root C. renda, which were extracted in n-hexane, ethyl acetate, dichloromethane, and water. The bioactivity of the fractionate, isolate, and positive control (ɑ-tocopherol) were used in the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The result showed that the ethyl acetate extract of fruit and roots had the highest antioxidant activity, with an IC50 value of 11.47 ± 0.169 µg/mL (very strong category) in the roots. In contrast, the IC50 value in the fruit was 10.69±0.084 g/mL. Further evaluating of antioxidant activity in the roots revealed that the IC50 value for isolate A was 28.17±0.232, while the IC50 value for isolate B was 24.80±0.296 g/mL. The fruit of isolation C had an IC50 value of 14.91±0.247 g/mL, while isolate D had an IC50 value of 25.98±0.133 g/mL. Compared to the antioxidant activity of ɑ-tocopherol, which has an IC50 value of 13.54±0.038, isolate C is very potent inhibit free radical scavenger. In contrast, the other isolates are two times lower than the positive control.
Uji toksisitas buah palem merah (Cyrtostachys renda Blume.) menggunakan metode brine shrimp lethality test (BSLT) method Syamsurizal Syamsurizal; Diah Tri Utami; Sutrisno Sutrisno; Emi Efrini; Muhammad Ikhsan Jumardi
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.429

Abstract

The red palm plant (Cyrtostachys renda) is a species of the Areca genus that grows widely in Jambi Province, making it an affordable plant to research for its medicinal properties. The Brine Shrimp Lethality Test (BSLT) is a toxicity test to screen for anticancer bioactive substances, with the test subject being Artemia salina Leach larvae, which are highly sensitive when exposed to toxic substances. The fruit and roots of C. renda were extracted using the maceration method by using a methanol solvent and partitioning using n-hexane, dichloromethane, ethyl acetate, and water. Based on the extract toxicity evaluation results, all extracts were toxic. Meanwhile, C.renda root dichloromethane extract had the highest toxic properties, with an LC50 value of 43.42 ± 0.659 ppm. However, the positive control's toxicity, potassium dichromate, was more toxic, with an LC50 value of 29.93 ± 0.668 ppm. The dichloromethane extract of C. renda roots can potentially be a poisonous agent. Further toxicity tests on cancer cells need to be carried out to be developed as an anticancer agent.
Co-Authors Amalia Rani Diah Tri Utami Emi Efrini Mira Ovita Damayani Muhammad Ikhsan Jumardi Puspa Dwi Pratiwi Ria Novia Sarah Dianora Sitanggang Sutrisno Sutrisno