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All Journal Pharmacon JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Majalah Farmaseutik Dinamisia: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Ilmiah Ilmu Terapan Universitas Jambi Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Sinteza Journal of Pharmaceutical and Sciences.
Puspa Dwi Pratiwi
Jurusan Farmasi, Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Jambi, Jambi, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Validasi Metode Analisis Matriks Patch Domperidon Maleat dengan Perbedaan Polimer Menggunakan Spektorfotometri UV-Vis Shesanthi Citrariana; Oktavia Indrati; Puspa Dwi Pratiwi; Ita Nurma Sari; Ari Wibowo
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.14576

Abstract

Uv-Vis spectrophotometry is an analytical method that can be used to determine the levels of domperidon maleate contained in transdermal patches with different polymers. The analysis method needs to be validated to prove that it can provide measurement results that match its designation. The purpose of this study is to prove that uv-vis spectrophotometry methods can provide the specificity, linearity, thoroughness, and precision that meet the requirements. In this study, linearity was known by calculating the r value on the curve of the relationship between levels and absorbance. Precision is obtained based on rsd value. Accuracy is calculated based on the return value. Selectiveity is known by means of identity confirmation that calculates the absorbance ratio at different wavelengths. The results showed that the method meets the requirements with a value of r=0.999; RSD precision results at a level of 10 ppm obtained RSD 0.236%. The accuracy values of 80%, 100%, and 120% in the matrix of transdermal domperidon maleate patches with PVA and PVP polymers respectively recovery was 99.50%, 101.15%, and 99.13%.. In the matrix of transdermal patches domperidon maleate with polymers HPMC and Na-CMC respectively recovery was 100.91%, 100.31%, and 100.67%. In the matrix of transdermal domperidon patches with HPMC and EC polymers respectively recovery was 98.00%, 98.00%, and 99.00%. The identity confirmation results on the transdermal domperidon patch matrix with PVA and PVP polymers, HPMC and Na-CMC, as well as HPMC and EC respectively have ratio value close to the standard solution with an average value of 0.800; 0,806; and 0.808. It can be concluded that the method of analyzing the levels of domperidone maleate in matrix of transdermal patches has qualified for good validity.
Optimasi Tablet Lepas Cepat Levofloksasin Hidroklorida Menggunakan Crospovidone Sebagai Disintegran dan Studi Disolusi Efisiensi Puspa Dwi Pratiwi; Akhmad Kharis Nugroho; Endang Lukitaningsih
Majalah Farmaseutik Vol 16, No 1 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.291 KB) | DOI: 10.22146/farmaseutik.v16i1.48352

Abstract

Tablet mengandung zat aktif dan eksipien yang berfungsi untuk meningkatkan sifat fisik tablet sehingga perlunya optimasi dan pengaruhnya terhadap sifat fisik tablet. Crospovidone merupakan salah satu disintegran yang diklaim dapat meningkatkan waktu hancur dan disolusi obat. Tujuan dari penelitian ini adalah melakukan optimasi tablet dan menentukan efek dari perbedaan jumlah crospovidone terhadap respon untuk mendapatkan formula optimal. Optimasi tablet dilakukan metode simplex lattice design dari perangkat lunak Design Expert versi 11 menggunakan dua variabel independen, yaitu crospovidone 2-10% dan laktosa monohidrat (45-53%). Preparasi tablet dilakukan menggunakan metode granulasi basah. Semua formula dilakukan uji sifat alir serbuk, kekerasan tablet, kerapuhan tablet, waktu hancur tablet, penentuan kadar levofloksasin dalam tablet, dan DE60. Formula optimal didapatkan dari respon kekerasan tablet, kerapuhan tablet, waktu hancur tablet, dan DE60. Formula optimal yang didapatkan adalah formula dengan jumlah crosspovidone 10% ditandai dengan nilai desirability 0,546 menghasilkan sifat fisik tablet berupa rata-rata kekerasan 4,33 kg, kerapuhan 0,49%, waktu hancur 6,36 menit, dan rata rata DE60 sebesar 75,00%. Terdapat perbedaan signifikan adanya perbedaan jumlah crospovidone terhadap waktu hancur. Tidak terdapat perbedaan signifikan antara respon prediksi yang diberikan perangkat lunak Design Expert versi 11 dengan hasil observasi sehingga simplex lattice design dari perangkat lunak Design Expert versi 11  mampu memprediksi respon secara akurat.
ETHNOPHARMACY SUKU ANAK DALAM OF BUNGKU VILLAGE, BAJUBANG DISTRICT, BATANGHARI REGENCY, JAMBI PROVINCE IN 2021 Puspa Dwi pratiwi
Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Vol. 8 No. 2 (2022): JURNAL PENELITIAN DAN KAJIAN ILMIAH KESEHATAN POLITEKNIK MEDICA FARMA HUSADA MA
Publisher : Politeknik Medica Farma Husada Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (697.817 KB) | DOI: 10.33651/jpkik.v8i2.418

Abstract

Suku Anak Dalam (SAD), the one of ethnics in Indonesia precisely on Jambi Province still use various types of plants and animals part as medical substance. Traditional medicine among local ethnics has differences of each other. In addition, the depletion of forests as a source of life and modern culture make traditional medicine been forgotten. The aim of this study was determine the souce of natural products used by SAD for medical purposes. It was a descriptive study using purposive sampling and snow ball sampling to get as much data as possible about medicinal plants or animals used by Suku Anak Dalam, Bungku Village. The results showed that there were 17 plats and 4 animals used by SAD for medicine. The disease are often experienced by Suku Anak dalam are stomachache, dyspepsia, kidney desease, dengue, hyperlipidemia, vulnus, toothache, and ascariasis. The part of natural product frequently used include root, stem, leaves, and sap, which were commonly processed by boiling, mashing, eating, searing, sticking, and burning. Based on the results that has been done that were 17 plants and 4 animals from different genus and family used as traditional medicine with different part and processed.
Aktivitas hepatoprotektor ektrak etanol daun durian ((Durio zibethinus Murr.) pada mencit yang diinduksi parasetamol Puspa Dwi Pratiwi; Nazrah Tiara; Intan lestari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.92

Abstract

Durian (Durio zibethinus Murr.) have been studied and reported has antioxidant activity and its potential as hepatoprotector. This study was determined the hepatoprotector activity and effective dose of ethanol extract of durian (Durio zibethinus Murr.) leave on mice. This experiment was experimental study using completely randomized design (CDR) with a post-test only control group design used 35 mice were divided into 5 treatment groups: negative control (NaCMC), positive control (acetaminophen 5.07 mg/20g bodyweight), treatment 1 (125 mg extract/kg bodyweight), treatment 2 (250 mg extract/kg bodyweight), and treatment 3 (500 mg extract/kg bodyweight). Secondary metabolites of extract, SGPT and SGOT of mice’s blood, and histopathology of mice’s liver was observed. This study showed that extract contained alkaloid, flavonoid, phenolic, and saponis. From SGPT and SGOT value, the results showed that the higher the extract was given, the level of SGPT and SGOT value decreased. Our study revealed that ethanol extract of durian leaves has activity as hepatoprotector and the effective dose was 500 mg/kg bodyweight.
Bahan Tambahan dalam Sediaan Tablet: Review Puspa Dwi Pratiwi; Shesanthi Citrariana; Baiq Maylinda Gemantari
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.17472

Abstract

Tablets are solid pharmaceutical dosage form without or with suitable excipients by press or compression manufacturing process. The excipient chosen can influence the product performance (physical properties and stability) and bioavailability. All excipients must be optimally selected to get the optimal formula of tablet dosage form. This article review aims to overview of excipient in tablet dosage form and their role in formulating tablet dosage form. this review article was written based on literature studies from electronic databases such as PubMed, ScienceDirect, and Google Scholar which contain related information using keyword in Indonesian or English use article published in 2013-2023. excipients in tablet dosage form are fillers or diluents, disintegrants, lubricants, preservatives, flavors, sweeteners, coloring, and coating agents. These excipients added to tablet dosage form to facilitating the process of manufacture tablet dosage form, increasing stability and effectiveness of active pharmaceutical ingredients in tablet. The conclusion of this review, there are many classification of tablet excipients which is different function to get compendial requirements of tablet dosage form.
Kajian aktivitas antioksidan pada isolat akar dan buah palem merah (Cyrtostachys renda Blume) dengan metode DPPH Syamsurizal Syamsurizal; Puspa Dwi Pratiwi; Ria Novia; Sarah Dianora Sitanggang; Amalia Rani; Mira Ovita Damayani
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.407

Abstract

Free radical reactions were increased in cells, leading to degenerative illnesses. Antioxidant components may inhibit free radical reactions. Exogenous antioxidants are primarily found in red palm (Cyrtostachys renda Blume). This study aimed to assess the potency of antioxidant activities of fruit and root C. renda, which were extracted in n-hexane, ethyl acetate, dichloromethane, and water. The bioactivity of the fractionate, isolate, and positive control (ɑ-tocopherol) were used in the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The result showed that the ethyl acetate extract of fruit and roots had the highest antioxidant activity, with an IC50 value of 11.47 ± 0.169 µg/mL (very strong category) in the roots. In contrast, the IC50 value in the fruit was 10.69±0.084 g/mL. Further evaluating of antioxidant activity in the roots revealed that the IC50 value for isolate A was 28.17±0.232, while the IC50 value for isolate B was 24.80±0.296 g/mL. The fruit of isolation C had an IC50 value of 14.91±0.247 g/mL, while isolate D had an IC50 value of 25.98±0.133 g/mL. Compared to the antioxidant activity of ɑ-tocopherol, which has an IC50 value of 13.54±0.038, isolate C is very potent inhibit free radical scavenger. In contrast, the other isolates are two times lower than the positive control.
Penentuan penangkal radikal dan sun protection factor krim kombinasi ekstrak etanol kunyit dan temu putih Puspa Dwi Pratiwi; Yuliawati Yuliawati; Fathnur Sani K; Uce Lestari
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.409

Abstract

Phytochemical studies about Curcuma genus such as Curcuma Longa and Curcuma zedoaria have shown the plants contains curcumin as the most isolated compound shown photoprotection agent and can be formulated as cream preparation. The concentration of Curcuma longa in cream preparation in this reseach was 0,5% and Curcuma zedoaria 0,5; 1; 1,5; 2; 2,5; and 3%. Cream preparations were physical evaluated of semi solid dosage form i.e pH organoleptic, spreadability, homogeneity, adhesion time and viscosity. The result was compared to SNI 16-4399-1996 (Indonesian Standard of UV protection preparation). All formulas were tested for radical scavenging activity using the DPPH method and SPF value determination. The results shown that formulas 3-6 met SNI requirements while formulas 1 and 2 did not met SNI from adhesion testing with results <1 second. Based on the antioxidant test results, it was found that formula 6 had the best antioxidant activity with lowest IC50 value of 126.69 ppm. It was linear as SPF value of formula 6 with 20.24 (ultra category). From this research, it was concluded that the greater of concentration of Curcuma zedoaria extract in cream preparation so free radical scavenger activity was better. Antioxidant activity is related to the SPF value of the preparation.
Optimasi gelling agent dan humektan dalam formula gel antioksidan ekstrak daun pepaya (Carica papaya Linn.) menggunakan metode simplex lattice design Puspa Dwi Pratiwi; Diah Riski Gusti; Resti Indah Angraini
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.430

Abstract

Papaya leaf (Carica papaya L.) have very strong antioxidant activity with IC50 value 21.08 ppm. C. papaya L. leaf can be formulated in gel preparation. The physical properties of gel and its effectiveness as an antioxidant can be affected by excipients, so it is necessary to optimize the formula. The aims of this research were to find the concentration of sodium carboxy methyl cellulose (Na-CMC) as gelling agent and glycerin as humectant to get optimal formula with the best physical properties and measure its antioxidant activity. Simplex lattice design (SLD) method was chosen for formula optimization with Na-CMC range 0.5-4% and glycerin 10-13.5%. The optimal formula was determined based on pH value, spreadability, stickiness and viscosity then determined for antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The results of this research were optimal formula with Na-CMC concentration 1.853% and glycerin 12.147%. The antioxidant activity of the optimal formula was decreased from the extract activity, with an IC50 value 21.08 ppm (very strong) to 61.70 ppm (strong). It can be concluded that the optimal formula for papaya leaf (C. papaya L.) extract gel preparation can be obtained with combination of Na-CMC and glycerin using the SLD method with strong antioxidant value.
Aplikasi Simplex Lattice Design untuk Optimasi Emulgator dalam Krim Minyak Atsiri Kulit Jeruk Manis Puspa Dwi Pratiwi; Deah Lestiana Arnas
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.26539

Abstract

In order to obtain a perfect emulsified and stable preparation, choosing the right composition emulsifier is crucial. Formula optimization is needed to determine the best combination of ingredients in formulation process based on evaluation responses. Simplex Lattice Design (SLD) is an experimental design method for mixing materials with the proportion of the total number of materials 1 or 100%. This research was aims to obtained the optimal cream formula using tween 80 and span 80 as emulsifiers and determined their effect on the physical properties of cream preparation. SLD method was used as optimization method with tween 80 and span 80 as independent variables and pH, viscosity, spreadability, and stickiness as responses. The minimum limit for tween 80 and span 80 is 1% (w/v) and the maximum is 9% (w/v) with total 10%. The optimal formula was obtained from consideration of the response by entering the target value to obtain a formula with desirability value close to 1. There are 5 formulas based on SLD recommendations, with a concentration ratio of tween 80 and span 80 9:1 (run 1); 7:3 (run 2); 1:9 (run 3); 5:5 (run 4); and 3:7 (run 5). The relationship between concentration and response value can be explained based on the significance of the model and equations obtained. The optimal formula was the concentration ratio of tween 80 and span 80 8.6:1.34 with a desirability value of 0.953. The conclusion of this research was that SLD can be used to optimize the emulsifier with response predictions close to the results obtained.
ANALISIS KADAR ALKOHOL PADA OBAT BATUK SIRUP ANAK: VALIDASI METODE HALAL PRODUK Shesanthi Citrariana; Puspa Dwi Pratiwi; Yahya Febrianto
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 1 (2024): Volume 7, No 1, Tahun 2024
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i1.52860

Abstract

The global halal market, including halal food and beverage products, is expected to continue to grow widely. Halal food and drinks according to Islamic law have the criteria of being free from alcoholic, intoxicating and dangerous drinks as well as food additives containing derivatives of these drinks. There are many medicinal preparations circulating on the market that contain alcohol, one of which is cough medicine. This study aims to validate the method and measure alcohol levels in children's cough medicine taken randomly on the market. The method used is GC (Gas Chromatography) with validation determination in the form of linearity tests, system suitability tests, accuracy, LOD and LOQ calculations. The results of this study show that the linearity is R = 0.998. In the system suitability test, the chromatographic N value was >1000, HETP <0.3, and R >1.5. The accuracy obtained is in the range 81.13% - 123.57%. The LOD value is 0.1106% and LOQ is 0.3352%. As well as alcohol residue found in cough medicine samples of 0.075%. From these results it can be concluded that the GC (Gas Chromatography) method used has good validity and the residual alcohol content in children's cough medicine preparations meets the BPOM and MUI halal requirements. Keywords: Gas Cromatography, validation, halal, medicine
Co-Authors Akhmad Kharis Nugroho Amalia Rani Apriati Kalimatus Sakdiyah Ari Wibowo ARIF RAHMAN Baiq Maylinda Gemantari Citrariana, Shesanthi Deah Lestiana Arnas Diah Riski Gusti Diky Okta Yudha Putra Elisma Elisma Endang Lukitaningsih Gianda Putri Rengganis Havizur Rahman Intan lestari Ita Nurma Sari Mira Ovita Damayani Muhaimin Muhaimin Nazrah Tiara Neviaisyah Zevani Putri Oktavia Indrati, Oktavia Resti Indah Angraini Ria Novia Sani K, Fathnur Sarah Dianora Sitanggang Sintia Prayuni syamsurizal syamsurizal Syamsurizal Syamsurizal Tiara Novita Sari Uce Lestari Veni Kurniati Vinnie Ayu Fitria Yahya Febrianto Yuliawati Yuliawati Yuliawati