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All Journal Pharmacon JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Majalah Farmaseutik Dinamisia: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Ilmiah Ilmu Terapan Universitas Jambi Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Journal of Pharmaceutical and Sciences.
Puspa Dwi Pratiwi
Jurusan Farmasi, Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Jambi, Jambi, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Validasi Metode Analisis Matriks Patch Domperidon Maleat dengan Perbedaan Polimer Menggunakan Spektorfotometri UV-Vis Shesanthi Citrariana; Oktavia Indrati; Puspa Dwi Pratiwi; Ita Nurma Sari; Ari Wibowo
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.14576

Abstract

Uv-Vis spectrophotometry is an analytical method that can be used to determine the levels of domperidon maleate contained in transdermal patches with different polymers. The analysis method needs to be validated to prove that it can provide measurement results that match its designation. The purpose of this study is to prove that uv-vis spectrophotometry methods can provide the specificity, linearity, thoroughness, and precision that meet the requirements. In this study, linearity was known by calculating the r value on the curve of the relationship between levels and absorbance. Precision is obtained based on rsd value. Accuracy is calculated based on the return value. Selectiveity is known by means of identity confirmation that calculates the absorbance ratio at different wavelengths. The results showed that the method meets the requirements with a value of r=0.999; RSD precision results at a level of 10 ppm obtained RSD 0.236%. The accuracy values of 80%, 100%, and 120% in the matrix of transdermal domperidon maleate patches with PVA and PVP polymers respectively recovery was 99.50%, 101.15%, and 99.13%.. In the matrix of transdermal patches domperidon maleate with polymers HPMC and Na-CMC respectively recovery was 100.91%, 100.31%, and 100.67%. In the matrix of transdermal domperidon patches with HPMC and EC polymers respectively recovery was 98.00%, 98.00%, and 99.00%. The identity confirmation results on the transdermal domperidon patch matrix with PVA and PVP polymers, HPMC and Na-CMC, as well as HPMC and EC respectively have ratio value close to the standard solution with an average value of 0.800; 0,806; and 0.808. It can be concluded that the method of analyzing the levels of domperidone maleate in matrix of transdermal patches has qualified for good validity.
Optimasi Tablet Lepas Cepat Levofloksasin Hidroklorida Menggunakan Crospovidone Sebagai Disintegran dan Studi Disolusi Efisiensi Puspa Dwi Pratiwi; Akhmad Kharis Nugroho; Endang Lukitaningsih
Majalah Farmaseutik Vol 16, No 1 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.291 KB) | DOI: 10.22146/farmaseutik.v16i1.48352

Abstract

Tablet mengandung zat aktif dan eksipien yang berfungsi untuk meningkatkan sifat fisik tablet sehingga perlunya optimasi dan pengaruhnya terhadap sifat fisik tablet. Crospovidone merupakan salah satu disintegran yang diklaim dapat meningkatkan waktu hancur dan disolusi obat. Tujuan dari penelitian ini adalah melakukan optimasi tablet dan menentukan efek dari perbedaan jumlah crospovidone terhadap respon untuk mendapatkan formula optimal. Optimasi tablet dilakukan metode simplex lattice design dari perangkat lunak Design Expert versi 11 menggunakan dua variabel independen, yaitu crospovidone 2-10% dan laktosa monohidrat (45-53%). Preparasi tablet dilakukan menggunakan metode granulasi basah. Semua formula dilakukan uji sifat alir serbuk, kekerasan tablet, kerapuhan tablet, waktu hancur tablet, penentuan kadar levofloksasin dalam tablet, dan DE60. Formula optimal didapatkan dari respon kekerasan tablet, kerapuhan tablet, waktu hancur tablet, dan DE60. Formula optimal yang didapatkan adalah formula dengan jumlah crosspovidone 10% ditandai dengan nilai desirability 0,546 menghasilkan sifat fisik tablet berupa rata-rata kekerasan 4,33 kg, kerapuhan 0,49%, waktu hancur 6,36 menit, dan rata rata DE60 sebesar 75,00%. Terdapat perbedaan signifikan adanya perbedaan jumlah crospovidone terhadap waktu hancur. Tidak terdapat perbedaan signifikan antara respon prediksi yang diberikan perangkat lunak Design Expert versi 11 dengan hasil observasi sehingga simplex lattice design dari perangkat lunak Design Expert versi 11  mampu memprediksi respon secara akurat.
ETHNOPHARMACY SUKU ANAK DALAM OF BUNGKU VILLAGE, BAJUBANG DISTRICT, BATANGHARI REGENCY, JAMBI PROVINCE IN 2021 Puspa Dwi pratiwi
Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Vol. 8 No. 2 (2022): JURNAL PENELITIAN DAN KAJIAN ILMIAH KESEHATAN POLITEKNIK MEDICA FARMA HUSADA MA
Publisher : Politeknik Medica Farma Husada Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (697.817 KB) | DOI: 10.33651/jpkik.v8i2.418

Abstract

Suku Anak Dalam (SAD), the one of ethnics in Indonesia precisely on Jambi Province still use various types of plants and animals part as medical substance. Traditional medicine among local ethnics has differences of each other. In addition, the depletion of forests as a source of life and modern culture make traditional medicine been forgotten. The aim of this study was determine the souce of natural products used by SAD for medical purposes. It was a descriptive study using purposive sampling and snow ball sampling to get as much data as possible about medicinal plants or animals used by Suku Anak Dalam, Bungku Village. The results showed that there were 17 plats and 4 animals used by SAD for medicine. The disease are often experienced by Suku Anak dalam are stomachache, dyspepsia, kidney desease, dengue, hyperlipidemia, vulnus, toothache, and ascariasis. The part of natural product frequently used include root, stem, leaves, and sap, which were commonly processed by boiling, mashing, eating, searing, sticking, and burning. Based on the results that has been done that were 17 plants and 4 animals from different genus and family used as traditional medicine with different part and processed.
Aktivitas hepatoprotektor ektrak etanol daun durian ((Durio zibethinus Murr.) pada mencit yang diinduksi parasetamol Puspa Dwi Pratiwi; Nazrah Tiara; Intan lestari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.92

Abstract

Durian (Durio zibethinus Murr.) have been studied and reported has antioxidant activity and its potential as hepatoprotector. This study was determined the hepatoprotector activity and effective dose of ethanol extract of durian (Durio zibethinus Murr.) leave on mice. This experiment was experimental study using completely randomized design (CDR) with a post-test only control group design used 35 mice were divided into 5 treatment groups: negative control (NaCMC), positive control (acetaminophen 5.07 mg/20g bodyweight), treatment 1 (125 mg extract/kg bodyweight), treatment 2 (250 mg extract/kg bodyweight), and treatment 3 (500 mg extract/kg bodyweight). Secondary metabolites of extract, SGPT and SGOT of mice’s blood, and histopathology of mice’s liver was observed. This study showed that extract contained alkaloid, flavonoid, phenolic, and saponis. From SGPT and SGOT value, the results showed that the higher the extract was given, the level of SGPT and SGOT value decreased. Our study revealed that ethanol extract of durian leaves has activity as hepatoprotector and the effective dose was 500 mg/kg bodyweight.
ANALISIS KADAR ALKOHOL PADA OBAT BATUK SIRUP ANAK: VALIDASI METODE HALAL PRODUK Shesanthi Citrariana; Puspa Dwi Pratiwi; Yahya Febrianto
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 1 (2024): Volume 7, No 1, Tahun 2024
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i1.52860

Abstract

The global halal market, including halal food and beverage products, is expected to continue to grow widely. Halal food and drinks according to Islamic law have the criteria of being free from alcoholic, intoxicating and dangerous drinks as well as food additives containing derivatives of these drinks. There are many medicinal preparations circulating on the market that contain alcohol, one of which is cough medicine. This study aims to validate the method and measure alcohol levels in children's cough medicine taken randomly on the market. The method used is GC (Gas Chromatography) with validation determination in the form of linearity tests, system suitability tests, accuracy, LOD and LOQ calculations. The results of this study show that the linearity is R = 0.998. In the system suitability test, the chromatographic N value was >1000, HETP <0.3, and R >1.5. The accuracy obtained is in the range 81.13% - 123.57%. The LOD value is 0.1106% and LOQ is 0.3352%. As well as alcohol residue found in cough medicine samples of 0.075%. From these results it can be concluded that the GC (Gas Chromatography) method used has good validity and the residual alcohol content in children's cough medicine preparations meets the BPOM and MUI halal requirements. Keywords: Gas Cromatography, validation, halal, medicine
BREADFRUIT PEEL AS THE MOST POTENT RADICAL SCAVENGERS FOR SKIN PROTECTION Syamsurizal Syamsurizal; Elisma Elisma; Puspa Dwi Pratiwi
Jurnal Ilmiah Ilmu Terapan Universitas Jambi Vol. 8 No. 1 (2024): Volume 8, Nomor 1, June 2024
Publisher : LPPM Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jiituj.v8i1.33966

Abstract

The sun's ultraviolet radiation causes erythema, premature aging, sunburn, hyperpigmentation, inflammation, and dry skin. For this purpose, sunscreen with an SPF value of over 15 is needed to protect the skin against UV rays. Breadfruit peel containing flavonoids may protect against free radicals and UV radiation. This study aims to increase SPF value from breadfruit fractionate by combining niacinamide and alpha-tocopherol. The ABTS and BSLT methods were used to screen potent free radical scavengers in n-hexane, dichloromethane, ethyl acetate, and methanol extracts. The dichloromethane extract had the highest potential as a free radical scavenger, with IC50 20,90 more or less 0,54, and the lowest toxicity, with LC50 234,42 more or less 1,06. Then, the scavenging activities and selective index of fractionates of dichloromethane were evaluated to show that the DM2 fraction had the strongest free radical scavenging activity and the lowest toxicity, with the highest selective index value of 46.08. The main active ingredient was DM2, combined with niacinamide and alpha-tocopherol into five compositions. The results of the lotion dosage forms revealed that the fifth formula, F5, met the requirement SNI standards and was stable during storage, with an SPF value of 20.61 more or less than 0.75, which was three times higher than the positive control with an SPF value of 6.67 more or less 1.28.
PENGARUH PEMBERIAN INFUSA DAUN SUNGKAI (PERONEMA CANESCENS) TERHADAP JUMLAH LEUKOSIT PADA MENCIT Rahman, Arif; Putri Rengganis, Gianda; Prayuni, Sintia; Novita Sari, Tiara; Dwi Pratiwi, Puspa; Pratama, Septa
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 7, No 2 (2021): OKTOBER 2021
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v7i2.1574

Abstract

ABSTRAK Sistem imun merupakan hal yang penting untuk melawan infeksi Virus. Di Indonesia banyak sekali tumbuhan yang mungkin memiliki efek imunostimulan bagi tubuh, salah satunya yaitu tumbuhan sungkai.. Penelitian ini bertujuan untuk membuktikan apakah infusa daun sungkai memiliki septa.pratama@gmail.com  aktifitas untuk meningkatkan leukosit pada mencit. 25 ekor mencit dibagi kedalam 5 kelompok. Kelompok 1 diberikan larutan NaCMC 1% sebagai kontrol negatif, Kelompok 2 diberikan suspensi stimuno dengan dosis 0.19mg/30 gBBmencit, Kelompok 3 diberikan infusa daun sungkai dengan konsentrasi 5%, Kelompok 4 diberikan infusa daun sungkai dengan konsentrasi 15%, Kelompok 5 diberikan infusa daun sungkai dengan konsentrasi 20%. Masing-masing Kelompok di beri perlakuan selama 7 hari dengan dosis 1xsehari. Parameter yang di ukur yaitu jumlah leukosit mencit  dan hasilnya di analisis menggunakan one way Anova dan uji lanjutan Bafferoni. Hasil yang diperoleh, infusa mengandung metabolit skunder Tanin, Fenol, Flavonoid, Terpenoid, Saponin, dan Alkaloid. Dari hasil Analisis Statistik di dapati perbedaan yang signifikan untuk kelima kelompok dengan p<0.05. Setelalah dilakukan uji lanjutan Bafferoni didapatkan bahwa terjadi perbedaan signifikan dengan p<0,05 untuk kelompok kontrol positif, infusa 15%, dan infusa 20% dibandingkan dengan kontrol negatif. Kemudian dibandingkan dengan kontrol positif hanya infusa 20% yang berbeda signifikan p<0.05 lebih banyak menghasilkan leukosit. Kesimpulannya, Infusa daun sungkai memiliki aktifitas sebagai imunostimulan Kata Kunci : Daun Sungkai, Imunomodulator, Infusa, covid-19 
Inspirational Health Profession Class at Baiturrahman Orphanage in Jambi: Kelas Inspirasi Profesi Kesehatan di Panti Asuhan Baiturrahman Jambi Yuliawati, Yuliawati; Muhaimin, Muhaimin; elisma, Elisma; Rahman, Havizur; Dwi Pratiwi, Puspa
Dinamisia : Jurnal Pengabdian Kepada Masyarakat Vol. 9 No. 1 (2025): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/dinamisia.v9i1.13256

Abstract

Kelas Inspirasi merupakan program mengajar oleh profesional dari berbagai profesi untuk mempengaruhi peserta didik agar membentuk sifat, keingintahuan, cara pandang dan motivasi peserta. Tujuan dari pengabdian ini adalah untuk memperkenalkan profesi kesehatan (ahli gizi, apoteker, bidan, dokter) dan dosen, meningkatkan minat belajar serta baca peserta. Metode yang dilakukan pada pengabdian ini adalah workshop secara online dan offline. Tempat pelaksanaan kegiatan di Panti Asuhan Baiturrahman dengan pesertanya adalah anak panti yang tidak mengenyam bangku sekolah negeri maupun swasta. Tahapan yang dilakukan diawali dengan observasi awal sekaligus Focus Group Disscussion (FGD), kemudian dilanjutkan dengan kegiatan workshop. Kegiatan workshop berlangsung 3 kali yaitu 14 Agustus, 21 Agustus dan 04 September 2021 dengan pemateri yaitu ahli gizi, apoteker, ketua organisasi, bidan, dokter, dosen dan guru besar. Kelas inspirasi ini berisi edukasi wawasan serta motivasi tentang profesi tersebut. Kegiatan ini sebagai motivasi awal agar anak panti rajin membaca buku karena untuk menjadi profesi kesehatan di atas membutuhkan nilai yang tinggi dan itu bisa terwujud dengan membaca buku. Peserta sangat antusias dan aktif dalam mengikuti materi yang diberikan dan pengabdian masyarakat ini mampu memberikan cara pandang dan motivasi terhadap peserta didik
Co-Authors Akhmad Kharis Nugroho Ari Wibowo Arif Rahman Citrariana, Shesanthi Elisma Elisma Elisma Elisma Endang Lukitaningsih Intan lestari Ita Nurma Sari Muhaimin Muhaimin Nazrah Tiara Novita Sari, Tiara Oktavia Indrati, Oktavia Prayuni, Sintia Putri Rengganis, Gianda Rahman, Havizur syamsurizal syamsurizal Yahya Febrianto Yuliawati