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Acute Toxicity Test of Gastroretentive Mucoadhesive Granule Preparation of Earthworm Flour (Lumbricus rubellus) Magfirah; Novalia Merue; Joni Tandi; Utami Islamiati
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8952

Abstract

Earthworms (Lumbricus rubellus) contain the compound lumbricin, which is beneficial for treatment, and its use is still simple, leading to the innovation of gastroretentive mucoadhesive granule formulations. However, its security has not yet been fully supported by research. This research aims to determine the toxic effects caused by earthworm granule preparations in terms of toxicity symptoms and the determination of the LD50 value. This research used 20 male white rats that were randomly divided into 4 groups. One control group was given Aquadest, and three treatment groups were given earthworm granules at doses of 500 mg/kgBB (P1), 2000 mg/kgBB (P2), and 5000 mg/kgBB (P3) with a single oral administration. The research results indicate that the preparation of earthworm granules (Lumbricus rubellus) causes toxic symptoms such as decreased locomotor activity, piloerection, and increased grooming frequency in line with the increase in dosage, but does not result in the death of the test animals. (LD50). Based on the research findings, it can be concluded that the LD50 value of the earthworm granules (Lumbricus rubellus) is >5000 mg/kgBB and falls into the practically non-toxic category with an LD50 range of 5–15 g/kgBB
Pengaruh Ekstrak Bunga Kecombrang (Etlingera elatior (Jack)) Terhadap Gambaran Histopatologi Lambung Pada Tikus Putih Jantan (Rattus norvegicus) Yang Diindukasi Streptozotocin Matra Novalia Palipadang; Syafika Alaydrus; Joni Tandi; Utami Islamiati; Ficanata Adhiguna Toding; Vianda Managanta
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1293

Abstract

Background: Hyperglycemia induced by streptozotocin (STZ) increases oxidative stress and inflammatory responses that may lead to gastric mucosal damage. Kecombrang flower (Etlingera elatior (Jack)) contains flavonoids and other secondary metabolites with antioxidant, anti-inflammatory, and antihyperglycemic properties that are potentially gastroprotective. Objective: This study aimed to evaluate the effect of ethanol extract of kecombrang flower on the histopathological profile of the stomach in male white rats (Rattus norvegicus) induced by streptozotocin and to determine the most effective dose. Methods: This experimental in vivo study employed a posttest-only control group design. Twenty-five male rats were divided into five groups (n=5): normal control, negative control (STZ-induced), positive control (STZ + glibenclamide), extract 50 mg/kg body weight (BW), and extract 100 mg/kg BW. Streptozotocin was administered intraperitoneally at 40 mg/kg BW. Gastric tissues were examined histopathologically using hematoxylin-eosin staining and assessed based on degeneration, necrosis, and inflammation scoring. Data were analyzed using Kruskal–Wallis followed by Mann–Whitney test with Bonferroni correction (p<0.05). Results: Phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, and tannins in the extract. Statistical analysis showed significant differences among groups in degeneration (p=0.013) and inflammation (p=0.047), but not in necrosis (p=1.000). The 100 mg/kg BW dose demonstrated the most prominent protective effect, with lower degeneration and inflammation scores and an average gastric damage score of 1, comparable to the positive control group. Conclusion: Ethanol extract of kecombrang flower at a dose of 100 mg/kg BW effectively reduced gastric histopathological damage in streptozotocin-induced male rats, indicating its potential gastroprotective activity through antioxidant and anti-inflammatory mechanisms.
Co-Authors Ficanata Adhiguna Toding Joni Tandi, Joni Matra Novalia Palipadang Novalia Merue Syafika Alaydrus Vianda Managanta