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All Journal Jurnal Farmasi Indonesia
Febriani, Fany
Unknown Affiliation
Medicine & Pharmacology

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OPTIMASI PENGGUNAAN ANTIMIKROBA BAGI PASIEN SEPSIS BERDASARKAN KARAKTERISTIK FARMAKOKINETIK DAN FARMAKODINAMIK OBAT: SEBUAH TINJAUAN LITERATUR Titiesari, Yovita Diane; Febriani, Fany
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 13 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.13 KB) | DOI: 10.35617/jfionline.v13i1.48

Abstract

Sepsis is one of a leading cause of death globally, and appropriate antimicrobial therapy is prominent to improve survival rate of septic patient. The pathophysiology of sepsis alongside with the use of therapeutic intervention such as renal replacement therapy could alter pharmacokinetic and pharmacodynamic profile of certain antimicrobials, thus will lead to subtherapeutic dose and treatment failure. This literature review will study the pharmacokinetic and pharmacodynamic profile of antimicrobials and its changes in septic patient and to apply this knowledge to optimise the dose of commonly used agents such as beta-lactams, vancomycin, aminoglycoside, fluoroquinolones, tigecycline, and antifungals, to improve patient’s safety
Co-Authors Titiesari, Yovita Diane