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All Journal Jurnal Riset Kefarmasian Indonesia Prosiding Konferensi Nasional PKM-CSR Jurnal Farmasi Indonesia
Febriani, Fany
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Humanities Control & Systems Engineering Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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OPTIMASI PENGGUNAAN ANTIMIKROBA BAGI PASIEN SEPSIS BERDASARKAN KARAKTERISTIK FARMAKOKINETIK DAN FARMAKODINAMIK OBAT: SEBUAH TINJAUAN LITERATUR Titiesari, Yovita Diane; Febriani, Fany
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 13 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.13 KB) | DOI: 10.35617/jfionline.v13i1.48

Abstract

Sepsis is one of a leading cause of death globally, and appropriate antimicrobial therapy is prominent to improve survival rate of septic patient. The pathophysiology of sepsis alongside with the use of therapeutic intervention such as renal replacement therapy could alter pharmacokinetic and pharmacodynamic profile of certain antimicrobials, thus will lead to subtherapeutic dose and treatment failure. This literature review will study the pharmacokinetic and pharmacodynamic profile of antimicrobials and its changes in septic patient and to apply this knowledge to optimise the dose of commonly used agents such as beta-lactams, vancomycin, aminoglycoside, fluoroquinolones, tigecycline, and antifungals, to improve patient’s safety
PENYULUHAN HIPERTENSI DAN DIABETES MELITUS PADA MASYARAKAT DESA CARINGIN, LEGOK, KABUPATEN TANGERANG Karnelasatri, Karnelasatri; Andriyani, Andriyani; Megawati, Febbyasi; Titiesari, Yovita Diane; Febriani, Fany; Beda, Kevin Adithya
Prosiding Konferensi Nasional Pengabdian Kepada Masyarakat dan Corporate Social Responsibility (PKM-CSR) Vol 8 (2025): Penguatan Ekonomi Masyarakat Berbasis Ekologis untuk Mencapai Keberlanjutan Menuju Ind
Publisher : Asosiasi Sinergi Pengabdi dan Pemberdaya Indonesia (ASPPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37695/pkmcsr.v8i0.2697

Abstract

Community Service activities in Caringin Village, Legok, were carried out through a series of activities including healthy exercises, health education, and free mini medical checkups. This program was conducted in collaboration with the Caringin Community Health Center, where educational materials on hypertension and diabetes mellitus (DM) were presented by doctors in the form of presentations, discussion, and health consultations. In addition, educational materials were also distributed via leaflets to reach residents who did not fully participate in the activities. The resident understanding was evaluated through pre- and post-tests, while activity implementation was evaluated through a satisfaction survey. The results of the free mini medical check-ups showed a high prevalence of hypertension, with 76% of residents having systolic blood pressure above 120 mmHg and 38% of them falling into the hypertension category of ≥140 mmHg. In addition, 17% of residents had blood sugar levels above normal, with 7% requiring further examination. The results of the evaluation of residents' understanding showed an average increase of 7%, while the satisfaction survey showed that the majority of residents were satisfied with the implementation of the activities (>90%). Some of the obstacles encountered were discrepancies in the number of participants who took the pretest and post-test, as well as misinterpretation of the pretest and post-test questions by residents, especially the elderly. However, this activity provided an overview of the effectiveness of an integrative approach to health education in raising awareness in the community and detecting early disease risks. Moreover, collaboration with local health service units provided opportunities for data-based follow-up on the results of the activity.
UJI EFEK ANTIBAKTERI KOMBINASI DAUN GEDI DAN DAUN KUMIS KUCING TERHADAP Staphyloccocus aureus Karnelasatri, Karnelasatri; Trisina, Jessica; Sekeon, Yehuda Yeziel Theofilus; Febriani, Fany
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i3.458

Abstract

            Gedi (Abelmoschus manihot (L.) Medik) and Java tea leaves (Orthosiphon aristatus (Blume) Miq.) are known to have antibacterial activity. The combination of these two plants in inhibiting Staphylococcus aureus bacteria needs to be known to determine whether there is a synergistic effect from the combination. The synergistic effects can be demonstrated by the presence of greater antibacterial activity in the combination of both plants compared to single plant extracts. The extraction of both leaves was carried out with 96% ethanol and the maceration method. Antibacterial assay utilized the disc diffusion method with an extract concentration of 10,000 ppm and an extract ratio between two extracts was 100:0, 75:25, 50:50, 25:75, and 0:100. The positive control used was gentamicin, while the negative control used was dimethyl sulfoxide (DMSO). The resulting inhibition zones of extract combinations were 8.21 mm, 9.49 mm, 7.86 mm, 8.03 mm, and 8.74 mm, respectively. The results of data analysis using One Way ANOVA showed a sig p> 0.05, which indicated that there was no significant difference between extract comparisons, both single and combined. Based on the inhibitory zones was obtained and the statistical analysis, the combination of 10.000 ppm 96% ethanol extract of Gedi and Java tea leaves had an antibacterial activity in the weak category and did not have a synergistic effect in inhibiting the growth of Staphylococcus aureus.
Co-Authors Andriyani Andriyani Beda, Kevin Adithya Karnelasatri, . Megawati, Febbyasi Sekeon, Yehuda Yeziel Theofilus Titiesari, Yovita Diane Trisina, Jessica