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OPTIMASI PENGGUNAAN ANTIMIKROBA BAGI PASIEN SEPSIS BERDASARKAN KARAKTERISTIK FARMAKOKINETIK DAN FARMAKODINAMIK OBAT: SEBUAH TINJAUAN LITERATUR Titiesari, Yovita Diane; Febriani, Fany
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.13 KB) | DOI: 10.35617/jfionline.v13i1.48

Abstract

Sepsis adalah salah satu penyebab kematian tertinggi di dunia, dan terapi antimikroba yang sesuai adalah salah satu kunci untuk meningkatkan keselamatan pasien sepsis. Patofisiologi sepsis dan penggunaan intervensi terapetik seperti renal replacement therapy akan menyebabkan perubahan farmakokinetik dan farmakodinamik antimikroba pada pasien sepsis, yang dapat menyebabkan kondisi subterapetik dan kegagalan terapi. Tinjauan literatur ini akan melihat aspek farmakokinetik dan farmakodinamik antimikroba serta perubahan aspek-aspek tersebut pada pasien sepsis dan mengaplikasikan pengetahuan ini untuk optimasi dosis antimikroba yang sering digunakan pada kondisi sepsis seperti beta-laktam, vankomisin, aminoglikosida, fluorokuinolon, tigesiklin, dan antijamur, untuk meningkatkan keselamatan pasien.
PENYULUHAN HIPERTENSI DAN DIABETES MELITUS PADA MASYARAKAT DESA CARINGIN, LEGOK, KABUPATEN TANGERANG Karnelasatri, Karnelasatri; Andriyani, Andriyani; Megawati, Febbyasi; Titiesari, Yovita Diane; Febriani, Fany; Beda, Kevin Adithya
Prosiding Konferensi Nasional Pengabdian Kepada Masyarakat dan Corporate Social Responsibility (PKM-CSR) Vol 8 (2025): Penguatan Ekonomi Masyarakat Berbasis Ekologis untuk Mencapai Keberlanjutan Menuju Ind
Publisher : Asosiasi Sinergi Pengabdi dan Pemberdaya Indonesia (ASPPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37695/pkmcsr.v8i0.2697

Abstract

Community Service activities in Caringin Village, Legok, were carried out through a series of activities including healthy exercises, health education, and free mini medical checkups. This program was conducted in collaboration with the Caringin Community Health Center, where educational materials on hypertension and diabetes mellitus (DM) were presented by doctors in the form of presentations, discussion, and health consultations. In addition, educational materials were also distributed via leaflets to reach residents who did not fully participate in the activities. The resident understanding was evaluated through pre- and post-tests, while activity implementation was evaluated through a satisfaction survey. The results of the free mini medical check-ups showed a high prevalence of hypertension, with 76% of residents having systolic blood pressure above 120 mmHg and 38% of them falling into the hypertension category of ≥140 mmHg. In addition, 17% of residents had blood sugar levels above normal, with 7% requiring further examination. The results of the evaluation of residents' understanding showed an average increase of 7%, while the satisfaction survey showed that the majority of residents were satisfied with the implementation of the activities (>90%). Some of the obstacles encountered were discrepancies in the number of participants who took the pretest and post-test, as well as misinterpretation of the pretest and post-test questions by residents, especially the elderly. However, this activity provided an overview of the effectiveness of an integrative approach to health education in raising awareness in the community and detecting early disease risks. Moreover, collaboration with local health service units provided opportunities for data-based follow-up on the results of the activity.