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The Potential of Saponin in Sea Cucumbers to Prevent Hyperlipidemia Talitha Syahla; Diki Wahyudi; Sima Smith; Yumna Iftinan Khalda; Zulfa Hasyimiyyah Ihtisyam; Dini Suryani
Jurnal Biologi Tropis Vol. 23 No. 4 (2023): October - December
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4.5740

Abstract

Hyperlipidemia is the main risk factor for atherosclerosis which can cause death. The occurrence of hyperlipidemia is relatively high with a percentage of 45% globally and 35% in Indonesia.  The purpose of this article is to determine the potential of saponins in sea cucumbers as the ingredients used to prevent hyperlipidemia. The method used in this article is a literature study by collecting relevant and focused articles. The literature used were the National Center for Biotechnology Information (NCBI), the Multidisciplinary Digital Publishing Institute (MDPI), and Google Scholar. The results of the literature review carried out are that the saponins found in sea cucumbers are the main component as a lipid reducer compared to other compounds found in sea cucumbers. In conclusion, saponins in sea cucumbers influence lipid metabolism which ultimately prevents hyperlipidemia through various mechanisms.
Vascular Cognitive Impairment and Vascular Dementia: A Literature Review Azka Fadila Latifa; Annisa Fitria Zahra AS; Muhammad Fatih Ma'ruf; Novad Sawelly; Dini Suryani; Herpan Syafii Harahap
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12784

Abstract

Vascular Cognitive Impairment and Dementia (VCID) is a spectrum of cognitive disorders associated with cerebrovascular disease and is a major cause of cognitive decline and dementia in older adults. This study aimed to review the etiology, risk factors, pathophysiology, diagnostic evaluation, and management of VCID to support early detection and appropriate intervention. A literature review was conducted using relevant scientific publications and clinical guidelines addressing VCID. The findings indicate that VCID develops through complex mechanisms involving chronic cerebral hypoperfusion, blood–brain barrier dysfunction, vascular inflammation, impaired brain fluid drainage, and neuronal injury. Major risk factors include advanced age, hypertension, diabetes mellitus, dyslipidemia, smoking, atrial fibrillation, and cardiovascular disease, which contribute to cerebrovascular damage and cognitive impairment. Diagnosis requires comprehensive cognitive assessment, particularly the Montreal Cognitive Assessment (MoCA), supported by magnetic resonance imaging (MRI) to identify vascular lesions and exclude other causes of cognitive decline. Management requires an integrated, multimodal approach involving vascular risk-factor control, appropriate pharmacological therapy, cognitive rehabilitation, physical activity, and family and caregiver support. In conclusion, VCID is a multifactorial disorder with substantial clinical and socioeconomic consequences. Early cognitive screening, optimal management of vascular risk factors, rehabilitation, and increased public awareness are essential to facilitate prevention, early diagnosis, and long-term care while slowing disease progression and improving quality of life.