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Sadakata Sinulingga
Department of Biochemistry and Medicinal Chemistry, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Excessive Sodium and Insufficient Potassium Consumption Can Elevate the Risk of Developing Hypertension Nanda Maharani Saqadifa; Ardesy Melizah Kurniati; Sadakata Sinulingga; Syarif Husin; Rizma Adlia Syakurah; Syarinta Adenina
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.172

Abstract

Introduction. Physiologically, there are setbacks and weaknesses in body functions in the elderly. This can cause inadequate food intake or eating imbalances in the elderly. Increased blood pressure is influenced by many factors such as sodium and potassium intake and less potassium intake can increase blood pressure. The purpose of this study was to determine the relationship of sodium and potassium intake from food with blood pressure in the elderly in the community dr. Mohammad Hoesin Hospital. Methods. An observational-analytic study was conducted on 120 elderly people using a cross-sectional research design conducted in the elderly community of dr. Mohammad Hoesin Hospital in October-November 2019. The sample of this study were members of the elderly community aged over 60 years, present when the study was conducted, willing to become a respondent and signed an informed consent. Data was obtained through filling out food record questionnaires, food recall interviews, personal data interviews, and direct measurement of blood pressure and nutritional status. To meet the research objectives, data were analyzed by Chi-square test. Results. In this study, there were 120 elderly people consisting of 3 men and 117 women. There was a significant relationship between sodium and potassium intake and blood pressure (p=0,003 and p=0,0001). Conclusion. There is a significant relationship between sodium and potassium intake with blood pressure in the elderly.
Inhibition Effect of N-Hexane Extract of Cherry Mistletoe Leaves (Dendropthtoe pentandra (L) Miq.) on Xanthine Oxidase Mario Saputra; Sadakata Sinulingga; Subandrate Subandrate
Biomedical Journal of Indonesia Vol. 10 No. 1 (2024): Vol 10, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i1.175

Abstract

Introduction. Cherry leaf extract has been found to have the potentiality to impede the xanthine oxidase enzyme. It is believed that cherry mistletoe leaves also possess similar properties as they are hemiparasites of their host. This study aims to determine the inhibition effect of N-Hexane extract of mistletoe cherry leaves on the xanthine oxidase. Methods. This research was conducted as an experimental in-vitro study. Cherry mistletoe leaves were extracted by N-Hexane solvent. The extract was divided into five doses, i.e. 40 mg/L, 20 mg/L, 10 mg/L, 5 mg/L, and 2.5 mg/L. Phytochemical screening was conducted to identify secondary metabolites. The impact of xanthine oxidase inhibition was quantified using a UV-vis spectrophotometer at wavelength of 400 nm. Results. N-Hexane extract of cherry mistletoe leaves contains alkaloids and triterpenoids. N-Hexane extract of mistletoe cherry leaves at a dose of 40 mg/L, 20 mg/L, 10 mg/L, 5 mg/L, and 2.5 mg/L was able to inhibit the xanthine oxidase enzyme with the line equation y = -0.2543x+ 91.305. The IC50 value for the N-Hexane extract of cherry mistletoe leaves is 162 mg/L Conclusion. N-Hexane extract of cherry mistletoe leaves has the potency to inhibit the xanthine oxidase enzyme in the medium category.
Serum Albumin and Globulin Levels in Pulmonary and Extrapulmonary Tuberculosis: A Cross-Sectional Study in Palembang Pearly Laurencia; Subandrate Subandrate; Sadakata Sinulingga; Dwi Indira Setyorini
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.333

Abstract

Introduction. Alterations in serum albumin and globulin reflect inflammatory responses in tuberculosis (TB), but evidence linking them to TB type remains inconsistent. This study investigated the association between serum albumin, globulin, albumin/globulin (A/G) ratio, and TB type (pulmonary [PTB] vs. extrapulmonary [EPTB]) in adult patients at Dr. Mohammad Hoesin Hospital, Palembang. Methods. A cross-sectional study was conducted among adult TB patients with measured serum albumin and globulin levels. TB type was categorized as PTB or EPTB. Associations were analyzed using chi-square tests, and prevalence ratios (PR) were calculated to quantify the strength of associations. Results. Among 251 patients, low serum albumin was more frequent in EPTB (41.7%) than in PTB (28.4%) (p = 0.006; PR = 1.802; 95% CI: 1.178–2.757), indicating EPTB patients were 1.8 times more likely to have low albumin. No significant association was observed for globulin: high globulin occurred in 56.7% of EPTB vs. 52.9% low-to-normal in PTB (p = 0.323; PR = 1.471; 95% CI: 0.682–3.174). Similarly, the A/G ratio showed no significant difference: low A/G ratio in 50% of PTB vs. 42.1% of EPTB (p = 0.676; PR = 1.376; 95% CI: 0.641–2.954). Conclusion. Lower serum albumin is significantly associated with EPTB compared to PTB, whereas globulin and the A/G ratio are not. Albumin may have potential as a supplementary clinical indicator of inflammatory status and disease manifestation in TB, though further longitudinal studies are warranted.
Co-Authors Ardesy Melizah Kurniati Dwi Indira Setyorini Mario Saputra Nanda Maharani Saqadifa Pearly Laurencia Rizma Adlia Syakurah Subandrate Syarif Husin Syarinta Adenina