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Theodora Putri Simanjaya
Faculty of Medicine, UPN Veteran Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Other

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THE EFFECTIVITY OF TRIPLE THERAPY COMPOSITION ON DYSPEPSIA WITH HELICOBACTER PYLORI INFECTION: A SYSTEMATIC REVIEW Theodora Putri Simanjaya; Erna Harfiani; Mila Citrawati
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 1 (2022): Vol.1 No.1 JUNE (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i1.4441

Abstract

Dyspepsia is a disease with one or more symptoms relating to abnormalities in gastroduodenal. One of the factors that influence dyspepsia is Helicobacter pylori (H. pylori). Clarithromycin-based triple therapy is recommended as first line eradication treatment. Resistance towards clarithromycin is increasing and causing eradication rates in Clarithromycin-based triple therapy to decrease. The purpose of this study was to determine the effectiveness of triple therapy variation on dyspepsia with H. pylori infection. Data was collected through literature searches on two different databases using the preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) 2020. This systematic review included all relevant articles from 2011-2021. Six studies met the inclusion criteria. The results showed that metronidazole-based triple therapy is effective in eradicating H. pylori due to its eradication rate surpassing the target rate of 80%. The highest eradication rates in intention-to-treat (ITT) and per-protocol (PP) were 94.3% and 93.5%, respectively. The best triple therapy composition is metronidazole-based triple therapy with 7 days of duration.
Co-Authors Erna Harfiani Mila Citrawati