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All Journal Proceeding of Mulawarman Pharmaceuticals Conferences Journal of Tropical Pharmacy and Chemistry
Nur Masyitah Zamruddin
Laboratorium Penelitian Dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Formulasi Sediaan Serum Wajah dari Ekstrak Sarang Burung Walet: Formulation of Facial Serum Preparations from Edible Bird's Nest Extract Ina Annisa Rahmadina; Fajar Prasetya; Nur Masyitah Zamruddin
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.707

Abstract

The swallow's nest (Edible bird's nest) is included in the Apodidae family. Swallow's nest contains several proteins and amino acids, glutathione and antioxidants. Swallow's nest also contains EGF (Epideral grow factor) which functions to regulate cell growth and development. Facial serum is a preparation with a high concentration of active substances and low viscosity, which can deliver a thin film of active ingredients to the skin surface. The results of this study aim to examine the stability of facial serum formulations from edible bird's nest extract. The results of this research produced facial serum preparations. The results of the physical testing showed that the swallow's nest extract facial serum preparation looked stable without any sediment. Keywords: Edible bird's nest, facial serum, stability test Abstrak Sarang burung walet (Edible bird’s nest) termasuk dalam family Apodidae. Sarang burung walet mengandung beberapa protein dan asam amino, glutathione serta antioksidan. Sarang burung walet juga mengandung EGF (Epideral grow factor)yang berfungsi mengatur pertumbuhan dan perkembangan sel. Serum wajah merupakan sediaan dengan zat aktif konsentrasi tinggi dan viskositas yang rendah, yang dapat menghantarkan film tipis dari bahan aktif pada permukaan kulit. Hasil dari penelitian ini bertujuan untuk melihat stabilitas formulasi sediaan serum wajah dari ekstrak sarang burung walet (Edible bird’s nest). Hasil penelitian ini menghasilkan sediaan serum wajah. Hasil dari pengujian fisik terlihat sediaan serum wajah ekstrak sarang burung walet terlihat stabil tanpa ada endapan. Kata Kunci: Edible bird’s nest, serum wajah, Uji stabilitas
In-Silico Screening of Mitragynine Derivates from the Genus Mitragyna Korth Targeting the Main Protease of the SARS-COV-2 Islamudin Ahmad; Nur Masyithah Zamruddin; M. Arifuddin; Yuspian Nur; Firzan Nainu
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.523

Abstract

Coronavirus Diseases 2019, caused by SARS-CoV-2, has been a significant threat to global public health. Unfortunately, effective COVID-19 vaccines and clinically-proven anti-SARS-CoV-2 drugs remain unavailable. This study was carried out aiming to predict the potential effect of mitragynine derivates from the Genus Mitragyna Korth as an inhibitor of Mpro, the main protease of the SARS-CoV-2, by in silico molecular docking study. The crystal structure of the main protease of SARS-CoV-2 as an active site target was obtained from the PDB database (rcsb.org) with PDB ID: 5R84 and 6LU7 with the native ligand of Z31792168 and N3, respectively. The analysis of in silico molecular docking was conducted using Autodock 4.2.6 (100 docking runs). The central grid was placed on HIS41 and CYS145 with a grid box comprised of 40x30x34 (for protein 5R84) and 36x62x40 (for protein 6LU7) points spaced by 0.375 Å was centered on the active site of X=9,812; Y=-0,257; Z=20,849 and X=-9.732; Y=11.403; X=68,483 (XYZ-coordinates), respectively. Our research indicated that mitrjavine and ajmalicine exhibit greater potential inhibition of the active site on the Mpro of SARS-CoV-2, even stronger than native ligands. We believed that these compounds are promising candidates to be examined in further COVID-19 drug discovery studies.
Co-Authors Fajar Prasetya Firzan Nainu Ina Annisa Rahmadina Islamudin Ahmad M. Arifuddin Yuspian Nur