Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA)
Gadis Anggraini
universitas indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Sintesis dan Uji Aktivitas Anti-inflamasi Senyawa 2‐Hidroksi‐N‐(Piridin‐2‐il)Benzamida Tersubstitusi Basa Mannich Morfolin dan N-Metilpiperazin Gadis Anggraini; Hayun Hayun; Catur Jatmika
Jurnal Penelitian Pendidikan IPA Vol 9 No 1 (2023): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i1.2319

Abstract

Salicylic acid is a naturally active substance known to have anti-inflammatory and antioxidant activity, but it has side effects in the gastrointestinal tract. The modification of its carboxylic groups into amide derivatives can be a solution to overcome its weakness. This study synthesized salicylamide analogs, 2-hydroxy-N-(pyridine-2-yl)benzamide (1) and, its Mannich base derivatives. The synthesized compounds (2a-b) showed anti-inflammatory activity based on an in-vitro anti-inflammatory activity test using the inhibition protein denaturation method. The IC50 obtained was in the range of 0.121-0.145 mM. The potency was lower than piroxicam used as a standard compound (IC50 = 0.0073 mM). The molecular docking result shows that the ratio of COX-2/COX-1 binding affinity and ligand interaction of all synthesized compounds were not COX-2 selective.
Co-Authors Catur Jatmika, Catur Hayun Hayun