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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia
Catur Jatmika, Catur
Faculty Of Pharmacy, Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Evaluasi Aktivitas Antioksidan Senyawa 4-[(E)-2-(4-okso-3-fenilkuinazolin-2-il)etenil]-benzensulfonamida dan Analognya Jatmika, Catur; Maggadani, Baitha Palanggatan; Hayun, Hayun
Pharmaceutical Sciences and Research Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

Quinazolinone derivative compounds exhibit a broad spectrum of biological activity, including antioxidant. Quinazolinone derivative compound 4-[(E)-2-(4-oxo-3-phenyl quinazolin-2-yl)ethenyl]-benzensulfonamida and its analogs (2a-f) have been synthesized and demonstrated its activity as a selective inhibitor of cyclooxygenase-2. The aim of this research was to evaluate the antioxidant activity of compound 4-[(E) -2-(4-oxo-3-fenilkuinazolin-2-yl)ethenyl]-benzensulfonamida and its analogs with DPPH radical scavenging method, ferric reducing activity potential (FRAP), and phosphomolybdenum method. The experiment revealed that the % inhibition and antioxidant capacity of compound 2c, 2e and 2f were higher compared to compound 2a, 2b and 2d. The DPPH radical scavenging analysis found that the % inhibition of compound 2c, 2e and 2f at high concentration of compound solution (1000 µg/mL) were 4.8 %, 3.46 %, and 3.68 %, respectively. While the total antioxidant capacity of compound 2c, 2e and 2f were recorded 37.93, 33.4, and 46.3 µg ascorbic acid equivalence/mg of compound, respectively. However the antioxidant activity of all synthesized compounds (2a-f) were lower than the standard ascorbic acid.
Sintesis dan Uji Aktivitas Anti-inflamasi Senyawa 2‐Hidroksi‐N‐(Piridin‐2‐il)Benzamida Tersubstitusi Basa Mannich Morfolin dan N-Metilpiperazin Gadis Anggraini; Hayun Hayun; Catur Jatmika
Jurnal Penelitian Pendidikan IPA Vol 9 No 1 (2023): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i1.2319

Abstract

Salicylic acid is a naturally active substance known to have anti-inflammatory and antioxidant activity, but it has side effects in the gastrointestinal tract. The modification of its carboxylic groups into amide derivatives can be a solution to overcome its weakness. This study synthesized salicylamide analogs, 2-hydroxy-N-(pyridine-2-yl)benzamide (1) and, its Mannich base derivatives. The synthesized compounds (2a-b) showed anti-inflammatory activity based on an in-vitro anti-inflammatory activity test using the inhibition protein denaturation method. The IC50 obtained was in the range of 0.121-0.145 mM. The potency was lower than piroxicam used as a standard compound (IC50 = 0.0073 mM). The molecular docking result shows that the ratio of COX-2/COX-1 binding affinity and ligand interaction of all synthesized compounds were not COX-2 selective.
Pengembangan Metode Analisis Sitrinin dan Upaya Penurunan Produksi Sitrinin dalam Fermentasi Cair Monascus purpureus Jatmika, Catur; Wibowo, Marlia Singgih; Miftah, Amir Musadad
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.146

Abstract

Citrinin, a fluorescent compound that contaminates a number of agricultural products, is a toxic compound especially to the kidneys and liver. This study aimed to develop analysis method for citrinin by HPLC and to reduce the level of citrinin in broth extract from Monascus purpureus fermentation microbiologically. The citrinin extraction method from fermentation broth was optimized by various pH and extracting solvents. The citrinin extract was incubated with Bacillus firmus bacteria at various growth phases. The levels of citrinin in the extract decreased significantly after incubating for 24 hours with the bacteria. Citrinin was analyzed HPLC by fluorescence detector at λexc 330 nm and λem 500 nm, mobile phase 0.033 M phosphoric acid: acetonitrile (1: 1), flow rate 1 mL/min with an average retention time of 6.1 minutes. The recovery was in the range of 78-83%. The precision method as shown by the coefficient of variance of 2.1%, with limit of detection and quantitation 0.03 µg/mL and 0.11 µg/mL respectively. Linearity was expressed by a correlation coefficient (r) of 0.9996 and a coefficient of variation of the regression function (Vx0) of 1.3%. The citrinin level in the extract was 0.69 µg/mL. The levels of citrinin after incubation with nutrient broth media contain bacterial culture aged 5 hours, 9 hours, and 14 hours were 0.56 ± 0.03, 0.27 ± 0.02, 0.26 ± 0.01, and 0.24 ± 0.01 µg/mL, respectively. Incubation of Bacillus firmus bacteria on citrinin extract significantly reduced the levels of citrinin in the extract.
Beyond Use Date (BUD) Determination of Ambroxol Hydrochloride Syrup by High-Performance Liquid Chromatography – UV/VIS Detector Jatmika, Catur; Iswandana, Raditya; Lestari, Indah Dewi
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Ambroxol HCl is a mucolytic agent often used to treat respiratory disorders associated with excess mucus secretion. This study aims to determine the beyond-use date (BUD) of ambroxol HCl syrup on the market based on analysis of the decrease in drug content using High-Performance Liquid Chromatography (HPLC) – UV/Vis detector. The HPLC conditions were reversed-phase with a C18 column, mobile phase containing acetonitrile - phosphate buffer 0.05 M pH 4.5 (60:40) at a flow rate of 1.0 ml/min using UV detection at 248 nm. To determine BUD, five syrup preparations (brands) obtained from the Jakarta area were analyzed in triplicate. The retention time for ambroxol HCl was 4.62 minutes. In the validation, ambroxol HCl showed good linearity with r = 0.99985 in the 6 to 36 µg/ml. LOD and LOQ for ambroxol HCl were 0.74 µg/ml and 2.25 µg/ml, respectively. It is also fulfilled the accuracy and precision parameters with a % recovery from 99.04% to 100.94% and CV<2%. This method meets the requirements according to the ICH Q2(R1) guidelines and can be used for the assay of ambroxol HCl syrup. The ambroxol HCl level on all samples was still higher than 90% (until the 36th day). Normality test data result indicated that data must be divided into two groups that are sample A and B, and sample C, D, and E. In conclusion, the extrapolation result showed that the BUD ambroxol HCl syrup was 83 days for sample A and B, and 49 days for sample C, D, and E.
Co-Authors Baitha Palanggatan Maggadani Baitha Palanggatan Maggadani, Baitha Palanggatan Gadis Anggraini Hayun Hayun Hayun Hayun Hayun Hayun, Hayun Lestari, Indah Dewi MARLIA SINGGIH WIBOWO Miftah, Amir Musadad Raditya Iswandana